PubMed

Ceramide mediates insulin resistance by tumor necrosis factor-alpha in brown adipocytes by maintaining Akt in an inactive dephosphorylated state.

Teruel T, Hernandez R, Lorenzo M.

Diabetes. 2001 Nov;50(11):2563-71.PMID: 11679435 [PubMed - indexed for MEDLINE]Related articlesFree article

Ceramide mediates TNF-alpha-induced insulin resistance on GLUT4 gene expression in brown adipocytes.

Fernández-Veledo S, Hernandez R, Teruel T, Mas JA, Ros M, Lorenzo M.

Arch Physiol Biochem. 2006 Feb;112(1):13-22.PMID: 16754199 [PubMed - indexed for MEDLINE]Related articles

Akt mediates insulin induction of glucose uptake and up-regulation of GLUT4 gene expression in brown adipocytes.

Hernandez R, Teruel T, Lorenzo M.

FEBS Lett. 2001 Apr 13;494(3):225-31.PMID: 11311245 [PubMed - indexed for MEDLINE]Related articles

Rosiglitazone ameliorates insulin resistance in brown adipocytes of Wistar rats by impairing TNF-alpha induction of p38 and p42/p44 mitogen-activated protein kinases.

Hernandez R, Teruel T, de Alvaro C, Lorenzo M.

Diabetologia. 2004 Sep;47(9):1615-24. Epub 2004 Sep 9.PMID: 15365619 [PubMed - indexed for MEDLINE]Related articles

Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide.

Summers SA, Garza LA, Zhou H, Birnbaum MJ.

Mol Cell Biol. 1998 Sep;18(9):5457-64.PMID: 9710629 [PubMed - indexed for MEDLINE]Related articlesFree article

Akt mediates insulin rescue from apoptosis in brown adipocytes: effect of ceramide.

Navarro P, Valverde AM, Rohn JL, Benito M, Lorenzo M.

Growth Horm IGF Res. 2000 Oct;10(5):256-66.PMID: 11042022 [PubMed - indexed for MEDLINE]Related articles

Tumor necrosis factor-alpha and ceramides in insulin resistance.

Brindley DN, Wang CN, Mei J, Xu J, Hanna AN.

Lipids. 1999;34 Suppl:S85-8.PMID: 10419100 [PubMed - indexed for MEDLINE]Related articles

Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner.

de Alvaro C, Teruel T, Hernandez R, Lorenzo M.

J Biol Chem. 2004 Apr 23;279(17):17070-8. Epub 2004 Feb 4.PMID: 14764603 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-induced up-regulated uncoupling protein-1 expression is mediated by insulin receptor substrate 1 through the phosphatidylinositol 3-kinase/Akt signaling pathway in fetal brown adipocytes.

Valverde AM, Arribas M, Mur C, Navarro P, Pons S, Cassard-Doulcier AM, Kahn CR, Benito M.

J Biol Chem. 2003 Mar 21;278(12):10221-31. Epub 2003 Jan 13.PMID: 12525499 [PubMed - indexed for MEDLINE]Related articlesFree article

Okadaic acid inhibits insulin-induced glucose transport in fetal brown adipocytes in an Akt-independent and protein kinase C zeta-dependent manner.

Valverde AM, Lorenzo M, Navarro P, Mur C, Benito M.

FEBS Lett. 2000 Apr 21;472(1):153-8.PMID: 10781824 [PubMed - indexed for MEDLINE]Related articles

Liver X receptor agonists ameliorate TNFalpha-induced insulin resistance in murine brown adipocytes by downregulating protein tyrosine phosphatase-1B gene expression.

Fernández-Veledo S, Nieto-Vazquez I, Rondinone CM, Lorenzo M.

Diabetologia. 2006 Dec;49(12):3038-48. Epub 2006 Oct 27.PMID: 17072583 [PubMed - indexed for MEDLINE]Related articles

Ceramide-activated protein phosphatase involvement in insulin resistance via Akt, serine/arginine-rich protein 40, and ribonucleic acid splicing in L6 skeletal muscle cells.

Ghosh N, Patel N, Jiang K, Watson JE, Cheng J, Chalfant CE, Cooper DR.

Endocrinology. 2007 Mar;148(3):1359-66. Epub 2006 Dec 7.PMID: 17158207 [PubMed - indexed for MEDLINE]Related articlesFree article

Alterations in the insulin signaling pathway induced by immortalization and H-ras transformation of brown adipocytes.

Valverde AM, Lorenzo M, Teruel T, Benito M.

Endocrinology. 1997 Aug;138(8):3195-206.PMID: 9231768 [PubMed - indexed for MEDLINE]Related articlesFree article

Impact of lipid phosphatases SHIP2 and PTEN on the time- and Akt-isoform-specific amelioration of TNF-alpha-induced insulin resistance in 3T3-L1 adipocytes.

Ikubo M, Wada T, Fukui K, Ishiki M, Ishihara H, Asano T, Tsuneki H, Sasaoka T.

Am J Physiol Endocrinol Metab. 2009 Jan;296(1):E157-64. Epub 2008 Nov 11.PMID: 19001549 [PubMed - indexed for MEDLINE]Related articles

c-Jun N-terminal kinase 1/2 activation by tumor necrosis factor-alpha induces insulin resistance in human visceral but not subcutaneous adipocytes: reversal by liver X receptor agonists.

Fernández-Veledo S, Vila-Bedmar R, Nieto-Vazquez I, Lorenzo M.

J Clin Endocrinol Metab. 2009 Sep;94(9):3583-93. Epub 2009 Jun 30.PMID: 19567513 [PubMed - indexed for MEDLINE]Related articles

Insulin resistance induced by tumor necrosis factor-alpha in myocytes and brown adipocytes.

Lorenzo M, Fernández-Veledo S, Vila-Bedmar R, Garcia-Guerra L, De Alvaro C, Nieto-Vazquez I.

J Anim Sci. 2008 Apr;86(14 Suppl):E94-104. Epub 2007 Oct 16. Review.PMID: 17940160 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytes.

Ugi S, Imamura T, Maegawa H, Egawa K, Yoshizaki T, Shi K, Obata T, Ebina Y, Kashiwagi A, Olefsky JM.

Mol Cell Biol. 2004 Oct;24(19):8778-89.PMID: 15367694 [PubMed - indexed for MEDLINE]Related articlesFree article

Tumour necrosis factor-alpha activation of protein kinase B in WEHI-164 cells is accompanied by increased phosphorylation of Ser473, but not Thr308.

O'toole A, Moule SK, Lockyer PJ, Halestrap AP.

Biochem J. 2001 Oct 1;359(Pt 1):119-27.PMID: 11563975 [PubMed - indexed for MEDLINE]Related articlesFree article

Tumor necrosis factor-alpha causes insulin receptor substrate-2-mediated insulin resistance and inhibits insulin-induced adipogenesis in fetal brown adipocytes.

Valverde AM, Teruel T, Navarro P, Benito M, Lorenzo M.

Endocrinology. 1998 Mar;139(3):1229-38.PMID: 9492058 [PubMed - indexed for MEDLINE]Related articlesFree article

Essential role of insulin-like growth factor I receptor in insulin-induced fetal brown adipocyte differentiation.

Mur C, Arribas M, Benito M, Valverde AM.

Endocrinology. 2003 Feb;144(2):581-93.PMID: 12538620 [PubMed - indexed for MEDLINE]Related articlesFree article