PubMed

Islet amyloid develops diffusely throughout the pancreas before becoming severe and replacing endocrine cells.

Wang F, Hull RL, Vidal J, Cnop M, Kahn SE.

Diabetes. 2001 Nov;50(11):2514-20.PMID: 11679429 [PubMed - indexed for MEDLINE]Related articlesFree article

beta-cell glucokinase deficiency and hyperglycemia are associated with reduced islet amyloid deposition in a mouse model of type 2 diabetes.

Andrikopoulos S, Verchere CB, Terauchi Y, Kadowaki T, Kahn SE.

Diabetes. 2000 Dec;49(12):2056-62.PMID: 11118007 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased dietary fat promotes islet amyloid formation and beta-cell secretory dysfunction in a transgenic mouse model of islet amyloid.

Hull RL, Andrikopoulos S, Verchere CB, Vidal J, Wang F, Cnop M, Prigeon RL, Kahn SE.

Diabetes. 2003 Feb;52(2):372-9.PMID: 12540610 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of glycosaminoglycan synthesis and protein glycosylation with WAS-406 and azaserine result in reduced islet amyloid formation in vitro.

Hull RL, Zraika S, Udayasankar J, Kisilevsky R, Szarek WA, Wight TN, Kahn SE.

Am J Physiol Cell Physiol. 2007 Nov;293(5):C1586-93. Epub 2007 Sep 5.PMID: 17804609 [PubMed - indexed for MEDLINE]Related articlesFree article

Human islet amyloid polypeptide transgenic mice: in vivo and ex vivo models for the role of hIAPP in type 2 diabetes mellitus.

Höppener JW, Jacobs HM, Wierup N, Sotthewes G, Sprong M, de Vos P, Berger R, Sundler F, Ahrén B.

Exp Diabetes Res. 2008;2008:697035.PMID: 18497871 [PubMed - indexed for MEDLINE]Related articlesFree article

An in vitro model of early islet amyloid polypeptide (IAPP) fibrillogenesis using human IAPP-transgenic mouse islets.

Henson MS, Buman BL, Jordan K, Rahrmann EP, Hardy RM, Johnson KH, O'Brien TD.

Amyloid. 2006 Dec;13(4):250-9.PMID: 17107885 [PubMed - indexed for MEDLINE]Related articles

Intra- and extracellular amyloid fibrils are formed in cultured pancreatic islets of transgenic mice expressing human islet amyloid polypeptide.

de Koning EJ, Morris ER, Hofhuis FM, Posthuma G, Höppener JW, Morris JF, Capel PJ, Clark A, Verbeek JS.

Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8467-71.PMID: 8078905 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic background determines the extent of islet amyloid formation in human islet amyloid polypeptide transgenic mice.

Hull RL, Watts MR, Kodama K, Shen ZP, Utzschneider KM, Carr DB, Vidal J, Kahn SE.

Am J Physiol Endocrinol Metab. 2005 Oct;289(4):E703-9. Epub 2005 May 17. Erratum in: Am J Physiol Endocrinol Metab. 2006 Jan;290(1):E205. PMID: 15899941 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose- and time-dependence of islet amyloid formation in vitro.

Zraika S, Hull RL, Udayasankar J, Utzschneider KM, Tong J, Gerchman F, Kahn SE.

Biochem Biophys Res Commun. 2007 Mar 2;354(1):234-9. Epub 2007 Jan 2.PMID: 17222388 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of the amyloid-degrading enzyme neprilysin in mouse islets and potential role in islet amyloidogenesis.

Zraika S, Hull RL, Udayasankar J, Clark A, Utzschneider KM, Tong J, Gerchman F, Kahn SE.

Diabetes. 2007 Feb;56(2):304-10. Erratum in: Diabetes. 2007 Jun;56(6):1746. PMID: 17259373 [PubMed - indexed for MEDLINE]Related articlesFree article

The effect of apolipoprotein E deficiency on islet amyloid deposition in human islet amyloid polypeptide transgenic mice.

Vidal J, Verchere CB, Andrikopoulos S, Wang F, Hull RL, Cnop M, Olin KL, LeBoeuf RC, O'Brien KD, Chait A, Kahn SE.

Diabetologia. 2003 Jan;46(1):71-9. Epub 2003 Jan 9.PMID: 12637985 [PubMed - indexed for MEDLINE]Related articles

Postnatally disturbed pancreatic islet cell distribution in human islet amyloid polypeptide transgenic mice.

Wong HY, Ahrén B, Lips CJ, Höppener JW, Sundler F.

Regul Pept. 2003 May 15;113(1-3):89-94.PMID: 12686466 [PubMed - indexed for MEDLINE]Related articles

Pancreatic expression and secretion of human islet amyloid polypeptide in a transgenic mouse.

D'Alessio DA, Verchere CB, Kahn SE, Hoagland V, Baskin DG, Palmiter RD, Ensinck JW.

Diabetes. 1994 Dec;43(12):1457-61.PMID: 7958499 [PubMed - indexed for MEDLINE]Related articles

Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid.

Butler AE, Janson J, Soeller WC, Butler PC.

Diabetes. 2003 Sep;52(9):2304-14.PMID: 12941770 [PubMed - indexed for MEDLINE]Related articlesFree article

Extended life span is associated with insulin resistance in a transgenic mouse model of insulinoma secreting human islet amyloid polypeptide.

Andrikopoulos S, Hull RL, Verchere CB, Wang F, Wilbur SM, Wight TN, Marzban L, Kahn SE.

Am J Physiol Endocrinol Metab. 2004 Mar;286(3):E418-24. Epub 2003 Nov 12. Erratum in: Am J Physiol Endocrinol Metab. 2004 May;286(5):E862. PMID: 14613923 [PubMed - indexed for MEDLINE]Related articlesFree article

Extensive islet amyloid formation is induced by development of Type II diabetes mellitus and contributes to its progression: pathogenesis of diabetes in a mouse model.

Höppener JW, Oosterwijk C, Nieuwenhuis MG, Posthuma G, Thijssen JH, Vroom TM, Ahrén B, Lips CJ.

Diabetologia. 1999 Apr;42(4):427-34.PMID: 10230646 [PubMed - indexed for MEDLINE]Related articles

Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress.

Hull RL, Zraika S, Udayasankar J, Aston-Mourney K, Subramanian SL, Kahn SE.

Diabetologia. 2009 Jun;52(6):1102-11. Epub 2009 Apr 8.PMID: 19352619 [PubMed - indexed for MEDLINE]Related articles

Long-term treatment with rosiglitazone and metformin reduces the extent of, but does not prevent, islet amyloid deposition in mice expressing the gene for human islet amyloid polypeptide.

Hull RL, Shen ZP, Watts MR, Kodama K, Carr DB, Utzschneider KM, Zraika S, Wang F, Kahn SE.

Diabetes. 2005 Jul;54(7):2235-44.PMID: 15983227 [PubMed - indexed for MEDLINE]Related articlesFree article

Human islet amyloid polypeptide accumulates at similar sites in islets of transgenic mice and humans.

de Koning EJ, Höppener JW, Verbeek JS, Oosterwijk C, van Hulst KL, Baker CA, Lips CJ, Morris JF, Clark A.

Diabetes. 1994 May;43(5):640-4.PMID: 8168639 [PubMed - indexed for MEDLINE]Related articles

Macrophages and pancreatic islet amyloidosis.

de Koning EJ, van den Brand JJ, Mott VL, Chargé SB, Hansen BC, Bodkin NL, Morris JF, Clark A.

Amyloid. 1998 Dec;5(4):247-54.PMID: 10036582 [PubMed - indexed for MEDLINE]Related articles