PubMed

Reduced insulinotropic effect of gastric inhibitory polypeptide in first-degree relatives of patients with type 2 diabetes.

Meier JJ, Hücking K, Holst JJ, Deacon CF, Schmiegel WH, Nauck MA.

Diabetes. 2001 Nov;50(11):2497-504.PMID: 11679427 [PubMed - indexed for MEDLINE]Related articlesFree article

Similar insulin secretory response to a gastric inhibitory polypeptide bolus injection at euglycemia in first-degree relatives of patients with type 2 diabetes and control subjects.

Meier JJ, Nauck MA, Siepmann N, Greulich M, Holst JJ, Deacon CF, Schmidt WE, Gallwitz B.

Metabolism. 2003 Dec;52(12):1579-85.PMID: 14669159 [PubMed - indexed for MEDLINE]Related articles

Secretion of incretin hormones and the insulinotropic effect of gastric inhibitory polypeptide in women with a history of gestational diabetes.

Meier JJ, Gallwitz B, Askenas M, Vollmer K, Deacon CF, Holst JJ, Schmidt WE, Nauck MA.

Diabetologia. 2005 Sep;48(9):1872-81. Epub 2005 Jul 12.PMID: 16010522 [PubMed - indexed for MEDLINE]Related articles

Secretion of incretin hormones (GIP and GLP-1) and incretin effect after oral glucose in first-degree relatives of patients with type 2 diabetes.

Nauck MA, El-Ouaghlidi A, Gabrys B, Hücking K, Holst JJ, Deacon CF, Gallwitz B, Schmidt WE, Meier JJ.

Regul Pept. 2004 Nov 15;122(3):209-17.PMID: 15491793 [PubMed - indexed for MEDLINE]Related articles

Insulinotropic properties of synthetic human gastric inhibitory polypeptide in man: interactions with glucose, phenylalanine, and cholecystokinin-8.

Nauck M, Schmidt WE, Ebert R, Strietzel J, Cantor P, Hoffmann G, Creutzfeldt W.

J Clin Endocrinol Metab. 1989 Sep;69(3):654-62.PMID: 2668324 [PubMed - indexed for MEDLINE]Related articles

The glucose dependent insulinotropic polypeptide response to oral glucose and mixed meals is increased in patients with type 2 (non-insulin-dependent) diabetes mellitus.

Jones IR, Owens DR, Luzio S, Williams S, Hayes TM.

Diabetologia. 1989 Sep;32(9):668-77.PMID: 2676668 [PubMed - indexed for MEDLINE]Related articles

Stimulation of insulin secretion by intravenous bolus injection and continuous infusion of gastric inhibitory polypeptide in patients with type 2 diabetes and healthy control subjects.

Meier JJ, Gallwitz B, Kask B, Deacon CF, Holst JJ, Schmidt WE, Nauck MA.

Diabetes. 2004 Dec;53 Suppl 3:S220-4.PMID: 15561915 [PubMed - indexed for MEDLINE]Related articlesFree article

The pathophysiology of diabetes involves a defective amplification of the late-phase insulin response to glucose by glucose-dependent insulinotropic polypeptide-regardless of etiology and phenotype.

Vilsbøll T, Knop FK, Krarup T, Johansen A, Madsbad S, Larsen S, Hansen T, Pedersen O, Holst JJ.

J Clin Endocrinol Metab. 2003 Oct;88(10):4897-903.PMID: 14557471 [PubMed - indexed for MEDLINE]Related articlesFree article

KATP channel closure ameliorates the impaired insulinotropic effect of glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes.

Aaboe K, Knop FK, Vilsboll T, Vølund A, Simonsen U, Deacon CF, Madsbad S, Holst JJ, Krarup T.

J Clin Endocrinol Metab. 2009 Feb;94(2):603-8. Epub 2008 Dec 2.PMID: 19050053 [PubMed - indexed for MEDLINE]Related articles

Influence of gastric inhibitory polypeptide on pentagastrin-stimulated gastric acid secretion in patients with type 2 diabetes and healthy controls.

Meier JJ, Nauck MA, Kask B, Holst JJ, Deacon CF, Schmidt WE, Gallwitz B.

World J Gastroenterol. 2006 Mar 28;12(12):1874-80.PMID: 16609993 [PubMed - indexed for MEDLINE]Related articlesFree article

Incretin secretion in relation to meal size and body weight in healthy subjects and people with type 1 and type 2 diabetes mellitus.

Vilsbøll T, Krarup T, Sonne J, Madsbad S, Vølund A, Juul AG, Holst JJ.

J Clin Endocrinol Metab. 2003 Jun;88(6):2706-13.PMID: 12788877 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced hepatic insulin extraction in response to gastric inhibitory polypeptide compensates for reduced insulin secretion in normal-weight and normal glucose tolerant first-degree relatives of type 2 diabetic patients.

Rudovich NN, Rochlitz HJ, Pfeiffer AF.

Diabetes. 2004 Sep;53(9):2359-65.PMID: 15331546 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose dependent insulinotropic polypeptide (GIP) infused intravenously is insulinotropic in the fasting state in type 2 (non-insulin dependent) diabetes mellitus.

Jones IR, Owens DR, Luzio S, Hayes TM.

Horm Metab Res. 1989 Jan;21(1):23-6.PMID: 2647605 [PubMed - indexed for MEDLINE]Related articles

Twenty-four-hour insulin secretion rates, circulating concentrations of fuel substrates and gut incretin hormones in healthy offspring of Type II (non-insulin-dependent) diabetic parents: evidence of several aberrations.

Nyholm B, Walker M, Gravholt CH, Shearing PA, Sturis J, Alberti KG, Holst JJ, Schmitz O.

Diabetologia. 1999 Nov;42(11):1314-23.PMID: 10550415 [PubMed - indexed for MEDLINE]Related articles

Characterization of beta-cell function impairment in first-degree relatives of type 2 diabetic subjects: modeling analysis of 24-h triple-meal tests.

Mari A, Gastaldelli A, Natali A, Ostergard T, Schmitz O, Ferrannini E.

Am J Physiol Endocrinol Metab. 2005 Mar;288(3):E541-6. Epub 2004 Nov 2.PMID: 15522997 [PubMed - indexed for MEDLINE]Related articlesFree article

A supplementary infusion of glucose-dependent insulinotropic polypeptide (GIP) with a meal does not significantly improve the beta cell response or glucose tolerance in type 2 diabetes mellitus.

Jones IR, Owens DR, Vora J, Luzio SD, Hayes TM.

Diabetes Res Clin Pract. 1989 Nov 6;7(4):263-9.PMID: 2693029 [PubMed - indexed for MEDLINE]Related articles

Discovery of amino acid variants in the human glucose-dependent insulinotropic polypeptide (GIP) receptor: the impact on the pancreatic beta cell responses and functional expression studies in Chinese hamster fibroblast cells.

Almind K, Ambye L, Urhammer SA, Hansen T, Echwald SM, Holst JJ, Gromada J, Thorens B, Pedersen O.

Diabetologia. 1998 Oct;41(10):1194-8.PMID: 9794107 [PubMed - indexed for MEDLINE]Related articles

Defective amplification of the late phase insulin response to glucose by GIP in obese Type II diabetic patients.

Vilsbøll T, Krarup T, Madsbad S, Holst JJ.

Diabetologia. 2002 Aug;45(8):1111-9. Epub 2002 Jul 4.PMID: 12189441 [PubMed - indexed for MEDLINE]Related articles

The effect of age and glycemic level on the response of the beta-cell to glucose-dependent insulinotropic polypeptide and peripheral tissue sensitivity to endogenously released insulin.

Meneilly GS, Ryan AS, Minaker KL, Elahi D.

J Clin Endocrinol Metab. 1998 Aug;83(8):2925-32.PMID: 9709971 [PubMed - indexed for MEDLINE]Related articlesFree article

Gastric inhibitory polypeptide and glucagon-like peptide-1 in the pathogenesis of type 2 diabetes.

Nauck MA, Baller B, Meier JJ.

Diabetes. 2004 Dec;53 Suppl 3:S190-6. Review.PMID: 15561910 [PubMed - indexed for MEDLINE]Related articlesFree article