PubMed

A major gene effect on fasting insulin and insulin sensitivity in familial combined hyperlipidemia.

Pihlajamäki J, Austin M, Edwards K, Laakso M.

Diabetes. 2001 Oct;50(10):2396-401.PMID: 11574425 [PubMed - indexed for MEDLINE]Related articlesFree article

The Pro12A1a substitution in the peroxisome proliferator activated receptor gamma 2 is associated with an insulin-sensitive phenotype in families with familial combined hyperlipidemia and in nondiabetic elderly subjects with dyslipidemia.

Pihlajamäki J, Miettinen R, Valve R, Karjalainen L, Mykkänen L, Kuusisto J, Deeb S, Auwerx J, Laakso M.

Atherosclerosis. 2000 Aug;151(2):567-74.PMID: 10924736 [PubMed - indexed for MEDLINE]Related articles

G-250A substitution in promoter of hepatic lipase gene is associated with dyslipidemia and insulin resistance in healthy control subjects and in members of families with familial combined hyperlipidemia.

Pihlajamäki J, Karjalainen L, Karhapää P, Vauhkonen I, Taskinen MR, Deeb SS, Laakso M.

Arterioscler Thromb Vasc Biol. 2000 Jul;20(7):1789-95.PMID: 10894818 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired free fatty acid suppression during hyperinsulinemia is a characteristic finding in familial combined hyperlipidemia, but insulin resistance is observed only in hypertriglyceridemic patients.

Pihlajamäki J, Karjalainen L, Karhapää P, Vauhkonen I, Laakso M.

Arterioscler Thromb Vasc Biol. 2000 Jan;20(1):164-70.PMID: 10634813 [PubMed - indexed for MEDLINE]Related articlesFree article

Codon 54 polymorphism of the human intestinal fatty acid binding protein 2 gene is associated with dyslipidemias but not with insulin resistance in patients with familial combined hyperlipidemia.

Pihlajamäki J, Rissanen J, Heikkinen S, Karjalainen L, Laakso M.

Arterioscler Thromb Vasc Biol. 1997 Jun;17(6):1039-44.PMID: 9194752 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired insulin-stimulated glucose oxidation and free fatty acid suppression in patients with familial combined hyperlipidemia: a precursor defect for dyslipidemia?

Karjalainen L, Pihlajamäki J, Karhapää P, Laakso M.

Arterioscler Thromb Vasc Biol. 1998 Oct;18(10):1548-53.PMID: 9763525 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence of pleiotropic loci for fasting insulin, total fat mass, and abdominal visceral fat in a sedentary population: the HERITAGE family study.

Hong Y, Després JP, Rice T, Nadeau A, Province MA, Gagnon J, Leon AS, Skinner JS, Wilmore JH, Bouchard C, Rao DC.

Obes Res. 2000 Mar;8(2):151-9.PMID: 10757201 [PubMed - indexed for MEDLINE]Related articles

The hormone sensitive lipase gene in familial combined hyperlipidemia and insulin resistance.

Pihlajamäki J, Valve R, Karjalainen L, Karhapää P, Vauhkonen I, Laakso M.

Eur J Clin Invest. 2001 Apr;31(4):302-8.PMID: 11298776 [PubMed - indexed for MEDLINE]Related articles

Evidence of a major locus for lipoprotein lipase (LPL) activity in addition to a pleiotropic locus for both LPL and fasting insulin: results from the HERITAGE Family Study.

Hong Y, Rice T, Després JP, Gagnon J, Nadeau A, Bergeron J, Pérusse L, Bouchard C, Leon AS, Skinner JS, Wilmore JH, Rao DC.

Atherosclerosis. 1999 Jun;144(2):393-401.PMID: 10407500 [PubMed - indexed for MEDLINE]Related articles

Evidence of insulin resistant lipid metabolism in adipose tissue in familial combined hyperlipidemia, but not type 2 diabetes mellitus.

van der Kallen CJ, Voors-Pette C, Bouwman FG, Keizer HA, Lu JY, van de Hulst RR, Bianchi R, Janssen MJ, Keulen ET, Boeckx WD, Rotter JI, de Bruin TW.

Atherosclerosis. 2002 Oct;164(2):337-46.PMID: 12204806 [PubMed - indexed for MEDLINE]Related articles

Genotype at a major locus with large effects on apolipoprotein B levels predicts familial combined hyperlipidemia.

Jarvik GP, Beaty TH, Gallagher PR, Coates PM, Cortner JA.

Genet Epidemiol. 1993;10(4):257-70.PMID: 8224806 [PubMed - indexed for MEDLINE]Related articles

[Genetic factors in familial combined hyperlipidemia and insulin resistance syndrome associated with dyslipidemia]

Moulin P.

Ann Endocrinol (Paris). 1997;58(4):287-91. Review. French. PMID: 9436476 [PubMed - indexed for MEDLINE]Related articles

A common genetic mechanism determines plasma apolipoprotein B levels and dense LDL subfraction distribution in familial combined hyperlipidemia.

Juo SH, Bredie SJ, Kiemeney LA, Demacker PN, Stalenhoef AF.

Am J Hum Genet. 1998 Aug;63(2):586-94.PMID: 9683593 [PubMed - indexed for MEDLINE]Related articlesFree article

Complex segregation analysis provides evidence for a major gene acting on serum triglyceride levels in 55 British families with familial combined hyperlipidemia.

Cullen P, Farren B, Scott J, Farrall M.

Arterioscler Thromb. 1994 Aug;14(8):1233-49.PMID: 8049184 [PubMed - indexed for MEDLINE]Related articlesFree article

Variants in the PPARgamma gene affect fatty acid and glycerol metabolism in familial combined hyperlipidemia.

Eurlings PM, van der Kallen CJ, Vermeulen VM, de Bruin TW.

Mol Genet Metab. 2003 Nov;80(3):296-301.PMID: 14680975 [PubMed - indexed for MEDLINE]Related articles

Relationship between familial combined hyperlipidemia and insulin resistance.

Jackuliaková D, Vaverková H, Karásek D.

Vnitr Lek. 2008 Nov;54(11):1045-53.PMID: 19069677 [PubMed - indexed for MEDLINE]Related articles

Effect of insulin resistance, apoE2 allele, and smoking on combined hyperlipidemia.

Sijbrands EJ, Westendorp RG, Hoffer MJ, Havekes LM, Frants RR, Meinders AE, Frölich M, Smelt AH.

Arterioscler Thromb. 1994 Oct;14(10):1576-80.PMID: 7918307 [PubMed - indexed for MEDLINE]Related articlesFree article

TXNIP gene not associated with familial combined hyperlipidemia in the NHLBI Family Heart Study.

Coon H, Singh N, Dunn D, Eckfeldt JH, Province MA, Hopkins PN, Weiss R, Hunt SC, Leppert MF; NHLBI Family Heart Study.

Atherosclerosis. 2004 Jun;174(2):357-62.PMID: 15136067 [PubMed - indexed for MEDLINE]Related articles

Genetic predictors of FCHL in four large pedigrees. Influence of ApoB level major locus predicted genotype and LDL subclass phenotype.

Jarvik GP, Brunzell JD, Austin MA, Krauss RM, Motulsky AG, Wijsman E.

Arterioscler Thromb. 1994 Nov;14(11):1687-94.PMID: 7947591 [PubMed - indexed for MEDLINE]Related articlesFree article

USF1 contributes to high serum lipid levels in Dutch FCHL families and U.S. whites with coronary artery disease.

Lee JC, Weissglas-Volkov D, Kyttälä M, Sinsheimer JS, Jokiaho A, de Bruin TW, Lusis AJ, Brennan ML, van Greevenbroek MM, van der Kallen CJ, Hazen SL, Pajukanta P.

Arterioscler Thromb Vasc Biol. 2007 Oct;27(10):2222-7. Epub 2007 Aug 2.PMID: 17673701 [PubMed - indexed for MEDLINE]Related articlesFree article