PubMed

Hexosamine-induced fibronectin protein synthesis in mesangial cells is associated with increases in cAMP responsive element binding (CREB) phosphorylation and nuclear CREB: the involvement of protein kinases A and C.

Singh LP, Andy J, Anyamale V, Greene K, Alexander M, Crook ED.

Diabetes. 2001 Oct;50(10):2355-62.PMID: 11574420 [PubMed - indexed for MEDLINE]Related articlesFree article

Hexosamines and TGF-beta1 use similar signaling pathways to mediate matrix protein synthesis in mesangial cells.

Singh LP, Green K, Alexander M, Bassly S, Crook ED.

Am J Physiol Renal Physiol. 2004 Feb;286(2):F409-16. Epub 2003 Oct 14.PMID: 14559714 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of the complementary DNA for human glutamine:fructose-6-phosphate amidotransferase in mesangial cells enhances glucose-induced fibronectin synthesis and transcription factor cyclic adenosine monophosphate-responsive element binding phosphorylation.

Singh LP, Alexander M, Greene K, Crook ED.

J Investig Med. 2003 Feb;51(1):32-41.PMID: 12580319 [PubMed - indexed for MEDLINE]Related articles

Hexosamine regulation of glucose-mediated laminin synthesis in mesangial cells involves protein kinases A and C.

Singh LP, Crook ED.

Am J Physiol Renal Physiol. 2000 Oct;279(4):F646-54.PMID: 10997914 [PubMed - indexed for MEDLINE]Related articlesFree article

The effects of glucose and the hexosamine biosynthesis pathway on glycogen synthase kinase-3 and other protein kinases that regulate glycogen synthase activity.

Singh LP, Crook ED.

J Investig Med. 2000 Jul;48(4):251-8.PMID: 10916283 [PubMed - indexed for MEDLINE]Related articles

High glucose stimulates angiotensinogen gene expression and cell hypertrophy via activation of the hexosamine biosynthesis pathway in rat kidney proximal tubular cells.

Hsieh TJ, Fustier P, Zhang SL, Filep JG, Tang SS, Ingelfinger JR, Fantus IG, Hamet P, Chan JS.

Endocrinology. 2003 Oct;144(10):4338-49. Epub 2003 Jul 10.PMID: 12960040 [PubMed - indexed for MEDLINE]Related articlesFree article

An analysis of high glucose and glucosamine-induced gene expression and oxidative stress in renal mesangial cells.

Cheng DW, Jiang Y, Shalev A, Kowluru R, Crook ED, Singh LP.

Arch Physiol Biochem. 2006 Oct-Dec;112(4-5):189-218.PMID: 17178593 [PubMed - indexed for MEDLINE]Related articles

Transcriptional induction of cyclooxygenase-2 gene by okadaic acid inhibition of phosphatase activity in human chondrocytes: co-stimulation of AP-1 and CRE nuclear binding proteins.

Miller C, Zhang M, He Y, Zhao J, Pelletier JP, Martel-Pelletier J, Di Battista JA.

J Cell Biochem. 1998 Jun 15;69(4):392-413.PMID: 9620167 [PubMed - indexed for MEDLINE]Related articles

Hexosamine induction of oxidative stress, hypertrophy and laminin expression in renal mesangial cells: effect of the anti-oxidant alpha-lipoic acid.

Singh LP, Cheng DW, Kowluru R, Levi E, Jiang Y.

Cell Biochem Funct. 2007 Sep-Oct;25(5):537-50.PMID: 16892452 [PubMed - indexed for MEDLINE]Related articles

Phosphorylation of cAMP responsive element binding protein after treatment of mesangial cells with high glucose plus TGF beta or PMA.

Kreisberg JI, Radnik RA, Kreisberg SH.

Kidney Int. 1996 Sep;50(3):805-10.PMID: 8872954 [PubMed - indexed for MEDLINE]Related articles

Glucose-induced insulin resistance of phosphatidylinositol 3'-OH kinase and AKT/PKB is mediated by the hexosamine biosynthesis pathway.

Singh LP, Gennerette D, Simmons S, Crook ED.

J Diabetes Complications. 2001 Mar-Apr;15(2):88-96.PMID: 11274905 [PubMed - indexed for MEDLINE]Related articles

Emodin ameliorates glucose-induced matrix synthesis in human peritoneal mesothelial cells.

Chan TM, Leung JK, Tsang RC, Liu ZH, Li LS, Yung S.

Kidney Int. 2003 Aug;64(2):519-33.PMID: 12846747 [PubMed - indexed for MEDLINE]Related articles

Berberine reduces fibronectin and collagen accumulation in rat glomerular mesangial cells cultured under high glucose condition.

Liu W, Tang F, Deng Y, Li X, Lan T, Zhang X, Huang H, Liu P.

Mol Cell Biochem. 2009 May;325(1-2):99-105. Epub 2009 Jan 14.PMID: 19142714 [PubMed - indexed for MEDLINE]Related articles

P38 mitogen-activated protein kinase mediates hexosamine-induced TGFbeta1 mRNA expression in human mesangial cells.

Burt DJ, Gruden G, Thomas SM, Tutt P, Dell'Anna C, Viberti GC, Gnudi L.

Diabetologia. 2003 Apr;46(4):531-7. Epub 2003 Apr 5.PMID: 12679868 [PubMed - indexed for MEDLINE]Related articles

High glucose-induced transforming growth factor beta1 production is mediated by the hexosamine pathway in porcine glomerular mesangial cells.

Kolm-Litty V, Sauer U, Nerlich A, Lehmann R, Schleicher ED.

J Clin Invest. 1998 Jan 1;101(1):160-9.PMID: 9421478 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of glutamine:fructose-6-phosphate amidotransferase activity by high glucose and transforming growth factor beta in rat mesangial cells.

Crook ED, Simmons ST, Daniels M, Singh LP.

J Investig Med. 2000 Nov;48(6):427-34.PMID: 11094865 [PubMed - indexed for MEDLINE]Related articles

Rapid induction of the Grp78 gene by cooperative actions of okadaic acid and heat-shock in 9L rat brain tumor cells--involvement of a cAMP responsive element-like promoter sequence and a protein kinase A signaling pathway.

Chen KD, Hung JJ, Huang HL, Chang MD, Lai YK.

Eur J Biochem. 1997 Aug 15;248(1):120-9.PMID: 9310369 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-dependent insulinotropic polypeptide-mediated up-regulation of beta-cell antiapoptotic Bcl-2 gene expression is coordinated by cyclic AMP (cAMP) response element binding protein (CREB) and cAMP-responsive CREB coactivator 2.

Kim SJ, Nian C, Widenmaier S, McIntosh CH.

Mol Cell Biol. 2008 Mar;28(5):1644-56. Epub 2007 Dec 17.PMID: 18086876 [PubMed - indexed for MEDLINE]Related articlesFree article

High glucose-enhanced activation of mesangial cell p38 MAPK by ET-1, ANG II, and platelet-derived growth factor.

Tsiani E, Lekas P, Fantus IG, Dlugosz J, Whiteside C.

Am J Physiol Endocrinol Metab. 2002 Jan;282(1):E161-9.PMID: 11739097 [PubMed - indexed for MEDLINE]Related articlesFree article

Lisofylline, a novel antiinflammatory compound, protects mesangial cells from hyperglycemia- and angiotensin II-mediated extracellular matrix deposition.

Bolick DT, Hatley ME, Srinivasan S, Hedrick CC, Nadler JL.

Endocrinology. 2003 Dec;144(12):5227-31. Epub 2003 Aug 28.PMID: 12960000 [PubMed - indexed for MEDLINE]Related articlesFree article