PubMed

Intramyocellular lipid is associated with resistance to in vivo insulin actions on glucose uptake, antilipolysis, and early insulin signaling pathways in human skeletal muscle.

Virkamäki A, Korsheninnikova E, Seppälä-Lindroos A, Vehkavaara S, Goto T, Halavaara J, Häkkinen AM, Yki-Järvinen H.

Diabetes. 2001 Oct;50(10):2337-43.PMID: 11574417 [PubMed - indexed for MEDLINE]Related articlesFree article

Elevated fasting insulin concentrations associate with impaired insulin signaling in skeletal muscle of healthy subjects independent of obesity.

Korsheninnikova E, Seppälä-Lindroos A, Vehkavaara S, Goto T, Virkamäki A.

Diabetes Metab Res Rev. 2002 May-Jun;18(3):209-16.PMID: 12112939 [PubMed - indexed for MEDLINE]Related articles

Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects.

Jacob S, Machann J, Rett K, Brechtel K, Volk A, Renn W, Maerker E, Matthaei S, Schick F, Claussen CD, Häring HU.

Diabetes. 1999 May;48(5):1113-9.PMID: 10331418 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence against a role for insulin-signaling proteins PI 3-kinase and Akt in insulin resistance in human skeletal muscle induced by short-term GH infusion.

Jessen N, Djurhuus CB, Jørgensen JO, Jensen LS, Møller N, Lund S, Schmitz O.

Am J Physiol Endocrinol Metab. 2005 Jan;288(1):E194-9. Epub 2004 Aug 31.PMID: 15339744 [PubMed - indexed for MEDLINE]Related articlesFree article

Dissociation between fat-induced in vivo insulin resistance and proximal insulin signaling in skeletal muscle in men at risk for type 2 diabetes.

Storgaard H, Jensen CB, Björnholm M, Song XM, Madsbad S, Zierath JR, Vaag AA.

J Clin Endocrinol Metab. 2004 Mar;89(3):1301-11.PMID: 15001626 [PubMed - indexed for MEDLINE]Related articlesFree article

Skeletal muscle insulin resistance in normoglycemic subjects with a strong family history of type 2 diabetes is associated with decreased insulin-stimulated insulin receptor substrate-1 tyrosine phosphorylation.

Pratipanawatr W, Pratipanawatr T, Cusi K, Berria R, Adams JM, Jenkinson CP, Maezono K, DeFronzo RA, Mandarino LJ.

Diabetes. 2001 Nov;50(11):2572-8.PMID: 11679436 [PubMed - indexed for MEDLINE]Related articlesFree article

Fatty acid-induced insulin resistance: decreased muscle PI3K activation but unchanged Akt phosphorylation.

Kruszynska YT, Worrall DS, Ofrecio J, Frias JP, Macaraeg G, Olefsky JM.

J Clin Endocrinol Metab. 2002 Jan;87(1):226-34.PMID: 11788651 [PubMed - indexed for MEDLINE]Related articlesFree article

Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents.

Petersen KF, Dufour S, Shulman GI.

PLoS Med. 2005 Sep;2(9):e233. Epub 2005 Aug 16.PMID: 16089501 [PubMed - indexed for MEDLINE]Related articlesFree article

Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men.

Seppälä-Lindroos A, Vehkavaara S, Häkkinen AM, Goto T, Westerbacka J, Sovijärvi A, Halavaara J, Yki-Järvinen H.

J Clin Endocrinol Metab. 2002 Jul;87(7):3023-8.PMID: 12107194 [PubMed - indexed for MEDLINE]Related articlesFree article

Reversal of insulin resistance postpartum is linked to enhanced skeletal muscle insulin signaling.

Kirwan JP, Varastehpour A, Jing M, Presley L, Shao J, Friedman JE, Catalano PM.

J Clin Endocrinol Metab. 2004 Sep;89(9):4678-84.PMID: 15356080 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin resistance, intramyocellular lipid content, and plasma adiponectin in patients with type 1 diabetes.

Perseghin G, Lattuada G, Danna M, Sereni LP, Maffi P, De Cobelli F, Battezzati A, Secchi A, Del Maschio A, Luzi L.

Am J Physiol Endocrinol Metab. 2003 Dec;285(6):E1174-81. Epub 2003 Aug 21.PMID: 12933352 [PubMed - indexed for MEDLINE]Related articlesFree article

Normal insulin sensitivity and IMCL content in overweight humans are associated with higher fasting lipid oxidation.

Perseghin G, Scifo P, Danna M, Battezzati A, Benedini S, Meneghini E, Del Maschio A, Luzi L.

Am J Physiol Endocrinol Metab. 2002 Sep;283(3):E556-64.PMID: 12169449 [PubMed - indexed for MEDLINE]Related articlesFree article

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.

Griffin ME, Marcucci MJ, Cline GW, Bell K, Barucci N, Lee D, Goodyear LJ, Kraegen EW, White MF, Shulman GI.

Diabetes. 1999 Jun;48(6):1270-4.PMID: 10342815 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of intravenous and dietary lipid challenge on intramyocellular lipid content and the relation with insulin sensitivity in humans.

Bachmann OP, Dahl DB, Brechtel K, Machann J, Haap M, Maier T, Loviscach M, Stumvoll M, Claussen CD, Schick F, Häring HU, Jacob S.

Diabetes. 2001 Nov;50(11):2579-84.PMID: 11679437 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle.

Patti ME, Virkamäki A, Landaker EJ, Kahn CR, Yki-Järvinen H.

Diabetes. 1999 Aug;48(8):1562-71.PMID: 10426374 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased lipid availability impairs insulin-stimulated ATP synthesis in human skeletal muscle.

Brehm A, Krssak M, Schmid AI, Nowotny P, Waldhäusl W, Roden M.

Diabetes. 2006 Jan;55(1):136-40.PMID: 16380486 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes.

Petersen KF, Dufour S, Befroy D, Garcia R, Shulman GI.

N Engl J Med. 2004 Feb 12;350(7):664-71.PMID: 14960743 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin signaling in human skeletal muscle: time course and effect of exercise.

Wojtaszewski JF, Hansen BF, Kiens B, Richter EA.

Diabetes. 1997 Nov;46(11):1775-81.PMID: 9356025 [PubMed - indexed for MEDLINE]Related articles

Insulin signal transduction in skeletal muscle from glucose-intolerant relatives of type 2 diabetic patients [corrected].

Storgaard H, Song XM, Jensen CB, Madsbad S, Björnholm M, Vaag A, Zierath JR.

Diabetes. 2001 Dec;50(12):2770-8. Erratum in: Diabetes 2002 Feb;51(2):552. PMID: 11723060 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose turnover and adipose tissue lipolysis are insulin-resistant in healthy relatives of type 2 diabetes patients: is cellular insulin resistance a secondary phenomenon?

Eriksson JW, Smith U, Waagstein F, Wysocki M, Jansson PA.

Diabetes. 1999 Aug;48(8):1572-8.PMID: 10426375 [PubMed - indexed for MEDLINE]Related articlesFree article