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    Results: 1 to 20 of 140

    1.

    Small molecule insulin receptor activators potentiate insulin action in insulin-resistant cells.

    Li M, Youngren JF, Manchem VP, Kozlowski M, Zhang BB, Maddux BA, Goldfine ID.

    Diabetes. 2001 Oct;50(10):2323-8.PMID: 11574415 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Decreased insulin receptor (IR) autophosphorylation in fibroblasts from patients with PCOS: effects of serine kinase inhibitors and IR activators.

    Li M, Youngren JF, Dunaif A, Goldfine ID, Maddux BA, Zhang BB, Evans JL.

    J Clin Endocrinol Metab. 2002 Sep;87(9):4088-93.PMID: 12213853 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    A novel small molecule that directly sensitizes the insulin receptor in vitro and in vivo.

    Manchem VP, Goldfine ID, Kohanski RA, Cristobal CP, Lum RT, Schow SR, Shi S, Spevak WR, Laborde E, Toavs DK, Villar HO, Wick MM, Kozlowski MR.

    Diabetes. 2001 Apr;50(4):824-30.PMID: 11289048 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Regulation of insulin receptor function by a small molecule insulin receptor activator.

    Pender C, Goldfine ID, Manchem VP, Evans JL, Spevak WR, Shi S, Rao S, Bajjalieh S, Maddux BA, Youngren JF.

    J Biol Chem. 2002 Nov 15;277(46):43565-71. Epub 2002 Sep 3.PMID: 12213804 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Monoclonal antibody to the human insulin receptor, but not insulin, stimulates S6 kinase via human insulin receptors mutated at three major tyrosine autophosphorylation sites.

    Sung CK.

    J Cell Biochem. 1992 Mar;48(3):324-35.PMID: 1328257 [PubMed - indexed for MEDLINE]Related articles

    6.

    Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit.

    Maddux BA, Goldfine ID.

    Diabetes. 2000 Jan;49(1):13-9.PMID: 10615944 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling.

    Fiory F, Alberobello AT, Miele C, Oriente F, Esposito I, Corbo V, Ruvo M, Tizzano B, Rasmussen TE, Gammeltoft S, Formisano P, Beguinot F.

    Mol Cell Biol. 2005 Dec;25(24):10803-14.PMID: 16314505 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Differential effects of tumor necrosis factor-alpha on protein kinase C isoforms alpha and delta mediate inhibition of insulin receptor signaling.

    Rosenzweig T, Braiman L, Bak A, Alt A, Kuroki T, Sampson SR.

    Diabetes. 2002 Jun;51(6):1921-30.PMID: 12031982 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    The Q allele variant (GLN121) of membrane glycoprotein PC-1 interacts with the insulin receptor and inhibits insulin signaling more effectively than the common K allele variant (LYS121).

    Costanzo BV, Trischitta V, Di Paola R, Spampinato D, Pizzuti A, Vigneri R, Frittitta L.

    Diabetes. 2001 Apr;50(4):831-6.PMID: 11289049 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Alpha2-HSG, a specific inhibitor of insulin receptor autophosphorylation, interacts with the insulin receptor.

    Mathews ST, Chellam N, Srinivas PR, Cintron VJ, Leon MA, Goustin AS, Grunberger G.

    Mol Cell Endocrinol. 2000 Jun;164(1-2):87-98.PMID: 11026561 [PubMed - indexed for MEDLINE]Related articles

    11.

    Deletion of the insulin receptor beta-subunit acidic domain results in enhanced metabolic signaling.

    Rolband GC, Williams JF, Webster NJ, Olefsky JM.

    Endocrinology. 1993 Sep;133(3):1437-43.PMID: 8396020 [PubMed - indexed for MEDLINE]Related articles

    12.

    Dual mechanism of signal transducer and activator of transcription 5 activation by the insulin receptor.

    Le MN, Kohanski RA, Wang LH, Sadowski HB.

    Mol Endocrinol. 2002 Dec;16(12):2764-79.PMID: 12456798 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Deletion of residues 485-599 from the human insulin receptor abolishes antireceptor antibody binding and influences tyrosine kinase activation.

    Sung CK, Wong KY, Yip CC, Hawley DM, Goldfine ID.

    Mol Endocrinol. 1994 Mar;8(3):315-24.PMID: 8015549 [PubMed - indexed for MEDLINE]Related articles

    14.

    Transmembrane signalling by insulin via an insulin receptor mutated at tyrosines 1158, 1162, and 1163.

    Rafaeloff R, Maddux BA, Brunetti A, Sbraccia P, Sung CK, Patel R, Hawley DM, Goldfine ID.

    Biochem Biophys Res Commun. 1991 Sep 16;179(2):912-8.PMID: 1898412 [PubMed - indexed for MEDLINE]Related articles

    15.

    Overexpression of membrane glycoprotein PC-1 in MDA-MB231 breast cancer cells is associated with inhibition of insulin receptor tyrosine kinase activity.

    Belfiore A, Costantino A, Frasca F, Pandini G, Mineo R, Vigneri P, Maddux B, Goldfine ID, Vigneri R.

    Mol Endocrinol. 1996 Nov;10(11):1318-26.PMID: 8923458 [PubMed - indexed for MEDLINE]Related articles

    16.

    Overexpression of membrane glycoprotein PC-1 can influence insulin action at a post-receptor site.

    Kumakura S, Maddux BA, Sung CK.

    J Cell Biochem. 1998 Mar 1;68(3):366-77.PMID: 9518262 [PubMed - indexed for MEDLINE]Related articles

    17.

    Acute selective glycogen synthase kinase-3 inhibition enhances insulin signaling in prediabetic insulin-resistant rat skeletal muscle.

    Dokken BB, Sloniger JA, Henriksen EJ.

    Am J Physiol Endocrinol Metab. 2005 Jun;288(6):E1188-94. Epub 2005 Jan 25.PMID: 15671078 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Decreased in situ insulin receptor dephosphorylation in hyperglycemia-induced insulin resistance in rat adipocytes.

    Tang S, Le-Tien H, Goldstein BJ, Shin P, Lai R, Fantus IG.

    Diabetes. 2001 Jan;50(1):83-90.PMID: 11147799 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Elevated plasma cell membrane glycoprotein levels and diminished insulin receptor autophosphorylation in obese, insulin-resistant rhesus monkeys.

    Pender C, Ortmeyer HK, Hansen BC, Goldfine ID, Youngren JF.

    Metabolism. 2002 Apr;51(4):465-70.PMID: 11912555 [PubMed - indexed for MEDLINE]Related articles

    20.

    Activation of insulin signal transduction pathway and anti-diabetic activity of small molecule insulin receptor activators.

    Qureshi SA, Ding V, Li Z, Szalkowski D, Biazzo-Ashnault DE, Xie D, Saperstein R, Brady E, Huskey S, Shen X, Liu K, Xu L, Salituro GM, Heck JV, Moller DE, Jones AB, Zhang BB.

    J Biol Chem. 2000 Nov 24;275(47):36590-5.PMID: 10967116 [PubMed - indexed for MEDLINE]Related articlesFree article

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