PubMed

A role for protein phosphatase 2A-like activity, but not atypical protein kinase Czeta, in the inhibition of protein kinase B/Akt and glycogen synthesis by palmitate.

Cazzolli R, Carpenter L, Biden TJ, Schmitz-Peiffer C.

Diabetes. 2001 Oct;50(10):2210-8.PMID: 11574400 [PubMed - indexed for MEDLINE]Related articlesFree article

Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate.

Schmitz-Peiffer C, Craig DL, Biden TJ.

J Biol Chem. 1999 Aug 20;274(34):24202-10.PMID: 10446195 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes.

Chavez JA, Summers SA.

Arch Biochem Biophys. 2003 Nov 15;419(2):101-9.PMID: 14592453 [PubMed - indexed for MEDLINE]Related articles

Alterations of nPKC distribution, but normal Akt/PKB activation in denervated rat soleus muscle.

Lin Y, Brady MJ, Wolanske K, Holbert R, Ruderman NB, Yaney GC.

Am J Physiol Endocrinol Metab. 2002 Aug;283(2):E318-25.PMID: 12110537 [PubMed - indexed for MEDLINE]Related articlesFree article

Cell signalling of glucagon-like peptide-1 action in rat skeletal muscle.

Acitores A, González N, Sancho V, Valverde I, Villanueva-Peñacarrillo ML.

J Endocrinol. 2004 Mar;180(3):389-98.PMID: 15012593 [PubMed - indexed for MEDLINE]Related articlesFree article

Stimulation of glycogen synthesis by heat shock in L6 skeletal-muscle cells: regulatory role of site-specific phosphorylation of glycogen-associated protein phosphatase 1.

Moon B, Duddy N, Ragolia L, Begum N.

Biochem J. 2003 May 1;371(Pt 3):857-66.PMID: 12540292 [PubMed - indexed for MEDLINE]Related articlesFree article

Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake.

Green CJ, Göransson O, Kular GS, Leslie NR, Gray A, Alessi DR, Sakamoto K, Hundal HS.

J Biol Chem. 2008 Oct 10;283(41):27653-67. Epub 2008 Jul 31.PMID: 18669636 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of PDK1 in insulin-signaling pathway for glucose metabolism in 3T3-L1 adipocytes.

Yamada T, Katagiri H, Asano T, Tsuru M, Inukai K, Ono H, Kodama T, Kikuchi M, Oka Y.

Am J Physiol Endocrinol Metab. 2002 Jun;282(6):E1385-94.PMID: 12006370 [PubMed - indexed for MEDLINE]Related articlesFree article

Ceramide-activated protein phosphatase involvement in insulin resistance via Akt, serine/arginine-rich protein 40, and ribonucleic acid splicing in L6 skeletal muscle cells.

Ghosh N, Patel N, Jiang K, Watson JE, Cheng J, Chalfant CE, Cooper DR.

Endocrinology. 2007 Mar;148(3):1359-66. Epub 2006 Dec 7.PMID: 17158207 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of protein phosphatase 2A by palmitate inhibits AMP-activated protein kinase.

Wu Y, Song P, Xu J, Zhang M, Zou MH.

J Biol Chem. 2007 Mar 30;282(13):9777-88. Epub 2007 Jan 25.PMID: 17255104 [PubMed - indexed for MEDLINE]Related articlesFree article

Membrane localization of 3-phosphoinositide-dependent protein kinase-1 stimulates activities of Akt and atypical protein kinase C but does not stimulate glucose transport and glycogen synthesis in 3T3-L1 adipocytes.

Egawa K, Maegawa H, Shi K, Nakamura T, Obata T, Yoshizaki T, Morino K, Shimizu S, Nishio Y, Suzuki E, Kashiwagi A.

J Biol Chem. 2002 Oct 11;277(41):38863-9. Epub 2002 Jul 29.PMID: 12147684 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytes.

Ugi S, Imamura T, Maegawa H, Egawa K, Yoshizaki T, Shi K, Obata T, Ebina Y, Kashiwagi A, Olefsky JM.

Mol Cell Biol. 2004 Oct;24(19):8778-89.PMID: 15367694 [PubMed - indexed for MEDLINE]Related articlesFree article

Intracellular ceramide synthesis and protein kinase Czeta activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells.

Powell DJ, Turban S, Gray A, Hajduch E, Hundal HS.

Biochem J. 2004 Sep 1;382(Pt 2):619-29.PMID: 15193147 [PubMed - indexed for MEDLINE]Related articlesFree article

SH2-containing inositol phosphatase 2 negatively regulates insulin-induced glycogen synthesis in L6 myotubes.

Sasaoka T, Hori H, Wada T, Ishiki M, Haruta T, Ishihara H, Kobayashi M.

Diabetologia. 2001 Oct;44(10):1258-67.PMID: 11692174 [PubMed - indexed for MEDLINE]Related articles

Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells.

Watson ML, Coghlan M, Hundal HS.

Biochem J. 2009 Feb 1;417(3):791-801.PMID: 18922131 [PubMed - indexed for MEDLINE]Related articles

Human glycated albumin affects glucose metabolism in L6 skeletal muscle cells by impairing insulin-induced insulin receptor substrate (IRS) signaling through a protein kinase C alpha-mediated mechanism.

Miele C, Riboulet A, Maitan MA, Oriente F, Romano C, Formisano P, Giudicelli J, Beguinot F, Van Obberghen E.

J Biol Chem. 2003 Nov 28;278(48):47376-87. Epub 2003 Sep 11.PMID: 12970360 [PubMed - indexed for MEDLINE]Related articlesFree article

Burn injury impairs insulin-stimulated Akt/PKB activation in skeletal muscle.

Sugita H, Kaneki M, Sugita M, Yasukawa T, Yasuhara S, Martyn JA.

Am J Physiol Endocrinol Metab. 2005 Mar;288(3):E585-91. Epub 2004 Nov 9.PMID: 15536206 [PubMed - indexed for MEDLINE]Related articlesFree article

Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells.

Fontés G, Semache M, Hagman DK, Tremblay C, Shah R, Rhodes CJ, Rutter J, Poitout V.

Diabetes. 2009 Sep;58(9):2048-58. Epub 2009 Jun 5.PMID: 19502418 [PubMed - indexed for MEDLINE]Related articlesFree article

Partitioning-defective protein 6 regulates insulin-dependent glycogen synthesis via atypical protein kinase C.

Weyrich P, Kapp K, Niederfellner G, Melzer M, Lehmann R, Häring HU, Lammers R.

Mol Endocrinol. 2004 May;18(5):1287-300. Epub 2004 Feb 19.PMID: 14976222 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutational analysis of the coding regions of the genes encoding protein kinase B-alpha and -beta, phosphoinositide-dependent protein kinase-1, phosphatase targeting to glycogen, protein phosphatase inhibitor-1, and glycogenin: lessons from a search for genetic variability of the insulin-stimulated glycogen synthesis pathway of skeletal muscle in NIDDM patients.

Hansen L, Fjordvang H, Rasmussen SK, Vestergaard H, Echwald SM, Hansen T, Alessi D, Shenolikar S, Saltiel AR, Barbetti F, Pedersen O.

Diabetes. 1999 Feb;48(2):403-7.PMID: 10334321 [PubMed - indexed for MEDLINE]Related articlesFree article