PubMed

Decrease in beta-cell mass leads to impaired pulsatile insulin secretion, reduced postprandial hepatic insulin clearance, and relative hyperglucagonemia in the minipig.

Kjems LL, Kirby BM, Welsh EM, Veldhuis JD, Straume M, McIntyre SS, Yang D, Lefèbvre P, Butler PC.

Diabetes. 2001 Sep;50(9):2001-12.PMID: 11522665 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-cell function and mass in type 2 diabetes.

Larsen MO.

Dan Med Bull. 2009 Aug;56(3):153-64.PMID: 19728971 [PubMed - indexed for MEDLINE]Related articles

Postprandial suppression of glucagon secretion depends on intact pulsatile insulin secretion: further evidence for the intraislet insulin hypothesis.

Meier JJ, Kjems LL, Veldhuis JD, Lefèbvre P, Butler PC.

Diabetes. 2006 Apr;55(4):1051-6.PMID: 16567528 [PubMed - indexed for MEDLINE]Related articlesFree article

Pulsatile insulin secretion dictates systemic insulin delivery by regulating hepatic insulin extraction in humans.

Meier JJ, Veldhuis JD, Butler PC.

Diabetes. 2005 Jun;54(6):1649-56.PMID: 15919785 [PubMed - indexed for MEDLINE]Related articlesFree article

Loss of beta-cell mass leads to a reduction of pulse mass with normal periodicity, regularity and entrainment of pulsatile insulin secretion in Göttingen minipigs.

Larsen MO, Gotfredsen CF, Wilken M, Carr RD, Pørksen N, Rolin B.

Diabetologia. 2003 Feb;46(2):195-202. Epub 2003 Jan 11. Erratum in: Diabetologia. 2004 Jan;47(1):155. PMID: 12627318 [PubMed - indexed for MEDLINE]Related articles

Glyburide enhances the responsiveness of the beta-cell to glucose but does not correct the abnormal patterns of insulin secretion in noninsulin-dependent diabetes mellitus.

Shapiro ET, Van Cauter E, Tillil H, Given BD, Hirsch L, Beebe C, Rubenstein AH, Polonsky KS.

J Clin Endocrinol Metab. 1989 Sep;69(3):571-6.PMID: 2503533 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of impaired fasting glucose and glucose intolerance induced by an approximate 50% pancreatectomy.

Matveyenko AV, Veldhuis JD, Butler PC.

Diabetes. 2006 Aug;55(8):2347-56.PMID: 16873700 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon-like peptide 1 increases secretory burst mass of pulsatile insulin secretion in patients with type 2 diabetes and impaired glucose tolerance.

Ritzel R, Schulte M, Pørksen N, Nauck MS, Holst JJ, Juhl C, März W, Schmitz O, Schmiegel WH, Nauck MA.

Diabetes. 2001 Apr;50(4):776-84.PMID: 11289042 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of beta-cell rest by a Kir6.2/SUR1-selective K(ATP)-channel opener preserves beta-cell insulin stores and insulin secretion in human islets cultured at high (11 mM) glucose.

Ritzel RA, Hansen JB, Veldhuis JD, Butler PC.

J Clin Endocrinol Metab. 2004 Feb;89(2):795-805.PMID: 14764798 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of somatostatin on pulsatile insulin secretion: elective inhibition of insulin burst mass.

Pørksen N, Munn SR, Steers JL, Veldhuis JD, Butler PC.

Am J Physiol. 1996 Jun;270(6 Pt 1):E1043-9.PMID: 8764190 [PubMed - indexed for MEDLINE]Related articles

Reduction of beta cell mass: partial insulin secretory compensation from the residual beta cell population in the nicotinamide-streptozotocin Göttingen minipig after oral glucose in vivo and in the perfused pancreas.

Larsen MO, Rolin B, Gotfredsen CF, Carr RD, Holst JJ.

Diabetologia. 2004 Nov;47(11):1873-8. Epub 2004 Nov 24.PMID: 15565374 [PubMed - indexed for MEDLINE]Related articles

Bedtime administration of NN2211, a long-acting GLP-1 derivative, substantially reduces fasting and postprandial glycemia in type 2 diabetes.

Juhl CB, Hollingdal M, Sturis J, Jakobsen G, Agersø H, Veldhuis J, Pørksen N, Schmitz O.

Diabetes. 2002 Feb;51(2):424-9.PMID: 11812750 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms of sulfonylurea's stimulation of insulin secretion in vivo: selective amplification of insulin secretory burst mass.

Pørksen NK, Munn SR, Steers JL, Schmitz O, Veldhuis JD, Butler PC.

Diabetes. 1996 Dec;45(12):1792-7.PMID: 8922367 [PubMed - indexed for MEDLINE]Related articles

Effects of glucose ingestion versus infusion on pulsatile insulin secretion. The incretin effect is achieved by amplification of insulin secretory burst mass.

Pørksen N, Munn S, Steers J, Veldhuis JD, Butler PC.

Diabetes. 1996 Oct;45(10):1317-23.PMID: 8826965 [PubMed - indexed for MEDLINE]Related articles

Impact of glucagon response on postprandial hyperglycemia in men with impaired glucose tolerance and type 2 diabetes mellitus.

Henkel E, Menschikowski M, Koehler C, Leonhardt W, Hanefeld M.

Metabolism. 2005 Sep;54(9):1168-73.PMID: 16125528 [PubMed - indexed for MEDLINE]Related articles

Adaptations in pulsatile insulin secretion, hepatic insulin clearance, and beta-cell mass to age-related insulin resistance in rats.

Matveyenko AV, Veldhuis JD, Butler PC.

Am J Physiol Endocrinol Metab. 2008 Oct;295(4):E832-41. Epub 2008 Jul 29.PMID: 18664594 [PubMed - indexed for MEDLINE]Related articlesFree article

Diazoxide attenuates glucose-induced defects in first-phase insulin release and pulsatile insulin secretion in human islets.

Song SH, Rhodes CJ, Veldhuis JD, Butler PC.

Endocrinology. 2003 Aug;144(8):3399-405.PMID: 12865318 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of glucagon secretion.

Young A.

Adv Pharmacol. 2005;52:151-71. Review.PMID: 16492545 [PubMed - indexed for MEDLINE]Related articles

FK-614, a selective peroxisome proliferator-activated receptor gamma agonist, improves peripheral glucose utilization while decreasing hepatic insulin extraction in alloxan-induced diabetic dogs.

Uchino H, Kim T, Lam TK, Yoshii H, Klement P, Williams W, Kawamori R, Giacca A.

Metabolism. 2005 Sep;54(9):1250-8.PMID: 16125538 [PubMed - indexed for MEDLINE]Related articles

The conscious Göttingen minipig as a model for studying rapid pulsatile insulin secretion in vivo.

Larsen MO, Elander M, Sturis J, Wilken M, Carr RD, Rolin B, Pørksen N.

Diabetologia. 2002 Oct;45(10):1389-96. Epub 2002 Sep 5.PMID: 12378379 [PubMed - indexed for MEDLINE]Related articles