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The neuropeptide pituitary adenylate cyclase-activating polypeptide and islet function.

Filipsson K, Kvist-Reimer M, Ahrén B.

Diabetes. 2001 Sep;50(9):1959-69. Review.PMID: 11522660 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of VIP and PACAP in islet function.

Winzell MS, Ahrén B.

Peptides. 2007 Sep;28(9):1805-13. Epub 2007 May 6. Review.PMID: 17559974 [PubMed - indexed for MEDLINE]Related articles

[Physiological and therapeutic roles of PACAP in glucose metabolism and diabetes]

Nakata M, Yada T.

Nippon Yakurigaku Zasshi. 2004 Apr;123(4):267-73. Review. Japanese. PMID: 15056942 [PubMed - indexed for MEDLINE]Related articles

Current status of PACAP as a regulator of insulin secretion in pancreatic islets.

Yada T, Sakurada M, Nakata M, Ihida K, Yaekura K, Shioda S, Kikuchi M.

Ann N Y Acad Sci. 1996 Dec 26;805:329-40; discussion 341-2.PMID: 8993414 [PubMed - indexed for MEDLINE]Related articles

Pituitary adenylate cyclase-activating polypeptide (PACAP) is an islet substance serving as an intra-islet amplifier of glucose-induced insulin secretion in rats.

Yada T, Sakurada M, Ishihara H, Nakata M, Shioda S, Yaekura K, Hamakawa N, Yanagida K, Kikuchi M, Oka Y.

J Physiol. 1997 Dec 1;505 ( Pt 2):319-28.PMID: 9423175 [PubMed - indexed for MEDLINE]Related articlesFree article

Pituitary adenylate cyclase-activating polypeptide receptors mediating insulin secretion in rodent pancreatic islets are coupled to adenylate cyclase but not to PLC.

Jamen F, Puech R, Bockaert J, Brabet P, Bertrand G.

Endocrinology. 2002 Apr;143(4):1253-9.PMID: 11897681 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of pituitary adenylate cyclase-activating polypeptide in the pancreatic endocrine system.

Ahrén B.

Ann N Y Acad Sci. 2008 Nov;1144:28-35. Review.PMID: 19076360 [PubMed - indexed for MEDLINE]Related articles

PACAP is an islet neuropeptide which contributes to glucose-stimulated insulin secretion.

Filipsson K, Sundler F, Ahrén B.

Biochem Biophys Res Commun. 1999 Mar 24;256(3):664-7.PMID: 10080956 [PubMed - indexed for MEDLINE]Related articles

[Physiological significance of pituitary adenylate cyclase-activating polypeptide (PACAP) in the nervous system]

Hashimoto H.

Yakugaku Zasshi. 2002 Dec;122(12):1109-21. Review. Japanese. PMID: 12510388 [PubMed - indexed for MEDLINE]Related articlesFree article

Pituitary adenylate cyclase activating polypeptide is an extraordinarily potent intra-pancreatic regulator of insulin secretion from islet beta-cells.

Yada T, Sakurada M, Ihida K, Nakata M, Murata F, Arimura A, Kikuchi M.

J Biol Chem. 1994 Jan 14;269(2):1290-3.PMID: 8288592 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose dependence of insulinotropic actions of pituitary adenylate cyclase-activating polypeptide in insulin-secreting INS-1 cells.

Rosengren A, Filipsson K, Jing XJ, Reimer MK, Renström E.

Pflugers Arch. 2002 Jul;444(4):556-67. Epub 2002 Jun 12.PMID: 12136276 [PubMed - indexed for MEDLINE]Related articles

Pituitary adenylate cyclase activating polypeptide: a potential neuroprotective peptide.

Somogyvári-Vigh A, Reglodi D.

Curr Pharm Des. 2004;10(23):2861-89. Review.PMID: 15379674 [PubMed - indexed for MEDLINE]Related articles

PACAP and its receptors exert pleiotropic effects in the nervous system by activating multiple signaling pathways.

Zhou CJ, Shioda S, Yada T, Inagaki N, Pleasure SJ, Kikuyama S.

Curr Protein Pept Sci. 2002 Aug;3(4):423-39. Review.PMID: 12370005 [PubMed - indexed for MEDLINE]Related articles

[The discovery of pituitary adenylate cyclase activating polypeptide (PACAP) and its research progress]

Geng L, Ju G.

Sheng Li Ke Xue Jin Zhan. 1997 Jan;28(1):29-34. Review. Chinese. PMID: 10921074 [PubMed - indexed for MEDLINE]Related articles

[Transgenic mice overexpressing PACAP in pancreatic beta-cells: acute and chronic effects on insulin and glucose homeostasis]

Tomimoto S, Hashimoto H, Shintani N, Baba A.

Nippon Yakurigaku Zasshi. 2004 Apr;123(4):261-6. Review. Japanese. PMID: 15056941 [PubMed - indexed for MEDLINE]Related articles

Regulation of growth hormone release in common carp pituitary cells by pituitary adenylate cyclase-activating polypeptide: signal transduction involves cAMP- and calcium-dependent mechanisms.

Xiao D, Chu MM, Lee EK, Lin HR, Wong AO.

Neuroendocrinology. 2002 Nov;76(5):325-38.PMID: 12457043 [PubMed - indexed for MEDLINE]Related articles

Evidence of pituitary adenylate cyclase activating polypeptide (PACAP) in pancreatic islet cells by confocal microscopy.

Petruzzo P, Cappai A, Spiga S, Picciau S, Serra G, Fattore L, Onali P, Brotzu G.

Pancreas. 2001 Jul;23(1):68-71.PMID: 11451150 [PubMed - indexed for MEDLINE]Related articles

Signaling mechanisms underlying the insulinotropic effect of pituitary adenylate cyclase-activating polypeptide in HIT-T15 cells.

Klinteberg KA, Karlsson S, Ahrén B.

Endocrinology. 1996 Jul;137(7):2791-8.PMID: 8770899 [PubMed - indexed for MEDLINE]Related articles

Pituitary adenylate cyclase-activating polypeptide is a sympathoadrenal neurotransmitter involved in catecholamine regulation and glucohomeostasis.

Hamelink C, Tjurmina O, Damadzic R, Young WS, Weihe E, Lee HW, Eiden LE.

Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):461-6. Epub 2001 Dec 26.PMID: 11756684 [PubMed - indexed for MEDLINE]Related articlesFree article

Systemic administration of pituitary adenylate cyclase-activating polypeptide maintains beta-cell mass and retards onset of hyperglycaemia in beta-cell-specific calmodulin-overexpressing transgenic mice.

Tsunekawa S, Miura Y, Yamamoto N, Itoh Y, Ariyoshi Y, Senda T, Oiso Y, Niki I.

Eur J Endocrinol. 2005 May;152(5):805-11.PMID: 15879367 [PubMed - indexed for MEDLINE]Related articlesFree article