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    Results: 1 to 20 of 189

    1.

    Treatment of type 2 diabetes by adenoviral-mediated overexpression of the glucokinase regulatory protein.

    Slosberg ED, Desai UJ, Fanelli B, St Denny I, Connelly S, Kaleko M, Boettcher BR, Caplan SL.

    Diabetes. 2001 Aug;50(8):1813-20.PMID: 11473043 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Mice mutant for glucokinase regulatory protein exhibit decreased liver glucokinase: a sequestration mechanism in metabolic regulation.

    Farrelly D, Brown KS, Tieman A, Ren J, Lira SA, Hagan D, Gregg R, Mookhtiar KA, Hariharan N.

    Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14511-6.PMID: 10588736 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    An allosteric activator of glucokinase impairs the interaction of glucokinase and glucokinase regulatory protein and regulates glucose metabolism.

    Futamura M, Hosaka H, Kadotani A, Shimazaki H, Sasaki K, Ohyama S, Nishimura T, Eiki J, Nagata Y.

    J Biol Chem. 2006 Dec 8;281(49):37668-74. Epub 2006 Oct 6.PMID: 17028192 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Phenotypic correction of diabetic mice by adenovirus-mediated glucokinase expression.

    Desai UJ, Slosberg ED, Boettcher BR, Caplan SL, Fanelli B, Stephan Z, Gunther VJ, Kaleko M, Connelly S.

    Diabetes. 2001 Oct;50(10):2287-95.PMID: 11574410 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Characterization of glucokinase regulatory protein-deficient mice.

    Grimsby J, Coffey JW, Dvorozniak MT, Magram J, Li G, Matschinsky FM, Shiota C, Kaur S, Magnuson MA, Grippo JF.

    J Biol Chem. 2000 Mar 17;275(11):7826-31.PMID: 10713097 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    The role of the regulatory protein of glucokinase in the glucose sensory mechanism of the hepatocyte.

    de la Iglesia N, Mukhtar M, Seoane J, Guinovart JJ, Agius L.

    J Biol Chem. 2000 Apr 7;275(14):10597-603.PMID: 10744755 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Allosteric activators of glucokinase: potential role in diabetes therapy.

    Grimsby J, Sarabu R, Corbett WL, Haynes NE, Bizzarro FT, Coffey JW, Guertin KR, Hilliard DW, Kester RF, Mahaney PE, Marcus L, Qi L, Spence CL, Tengi J, Magnuson MA, Chu CA, Dvorozniak MT, Matschinsky FM, Grippo JF.

    Science. 2003 Jul 18;301(5631):370-3.PMID: 12869762 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Glucokinase regulatory protein is essential for the proper subcellular localisation of liver glucokinase.

    de la Iglesia N, Veiga-da-Cunha M, Van Schaftingen E, Guinovart JJ, Ferrer JC.

    FEBS Lett. 1999 Aug 6;456(2):332-8.PMID: 10456334 [PubMed - indexed for MEDLINE]Related articles

    9.

    Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia.

    O'Doherty RM, Lehman DL, Télémaque-Potts S, Newgard CB.

    Diabetes. 1999 Oct;48(10):2022-7.PMID: 10512368 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Glucose toxicity is responsible for the development of impaired regulation of endogenous glucose production and hepatic glucokinase in Zucker diabetic fatty rats.

    Fujimoto Y, Torres TP, Donahue EP, Shiota M.

    Diabetes. 2006 Sep;55(9):2479-90.PMID: 16936196 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Lack of glucokinase regulatory protein expression may contribute to low glucokinase activity in feline liver.

    Hiskett EK, Suwitheechon OU, Lindbloom-Hawley S, Boyle DL, Schermerhorn T.

    Vet Res Commun. 2009 Mar;33(3):227-40. Epub 2008 Sep 9.PMID: 18780155 [PubMed - indexed for MEDLINE]Related articles

    12.

    Stimulation of hepatocyte glucose metabolism by novel small molecule glucokinase activators.

    Brocklehurst KJ, Payne VA, Davies RA, Carroll D, Vertigan HL, Wightman HJ, Aiston S, Waddell ID, Leighton B, Coghlan MP, Agius L.

    Diabetes. 2004 Mar;53(3):535-41.PMID: 14988235 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Adenovirus-mediated expression of glucokinase in the liver as an adjuvant treatment for type 1 diabetes.

    Morral N, McEvoy R, Dong H, Meseck M, Altomonte J, Thung S, Woo SL.

    Hum Gene Ther. 2002 Sep 1;13(13):1561-70.PMID: 12228011 [PubMed - indexed for MEDLINE]Related articles

    14.

    A potential role for fructose-2,6-bisphosphate in the stimulation of hepatic glucokinase gene expression.

    Wu C, Okar DA, Stoeckman AK, Peng LJ, Herrera AH, Herrera JE, Towle HC, Lange AJ.

    Endocrinology. 2004 Feb;145(2):650-8. Epub 2003 Nov 14.PMID: 14617577 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Effect of high-fat diet on glucose homeostasis and gene expression in glucokinase knockout mice.

    Gorman T, Hope DC, Brownlie R, Yu A, Gill D, Löfvenmark J, Wedin M, Mayers RM, Snaith MR, Smith DM.

    Diabetes Obes Metab. 2008 Sep;10(10):885-97. Epub 2007 Nov 22.PMID: 18034843 [PubMed - indexed for MEDLINE]Related articles

    16.

    For the ZDF rat, "Breaking up is hard to do": dissociation of the GK:GKRP complex.

    Lange AJ.

    Am J Physiol Regul Integr Comp Physiol. 2007 Apr;292(4):R1379-80. Epub 2006 Dec 21. No abstract available. PMID: 17185403 [PubMed - indexed for MEDLINE]Related articles

    17.

    Substrate-induced nuclear export and peripheral compartmentalization of hepatic glucokinase correlates with glycogen deposition.

    Jetton TL, Shiota M, Knobel SM, Piston DW, Cherrington AD, Magnuson MA.

    Int J Exp Diabetes Res. 2001;2(3):173-86.PMID: 12369705 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Biophysical characterization of the interaction between hepatic glucokinase and its regulatory protein: impact of physiological and pharmacological effectors.

    Anderka O, Boyken J, Aschenbach U, Batzer A, Boscheinen O, Schmoll D.

    J Biol Chem. 2008 Nov 14;283(46):31333-40. Epub 2008 Sep 22.PMID: 18809676 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Adult rat liver cells transdifferentiated with lentiviral IPF1 vectors reverse diabetes in mice: an ex vivo gene therapy approach.

    Fodor A, Harel C, Fodor L, Armoni M, Salmon P, Trono D, Karnieli E.

    Diabetologia. 2007 Jan;50(1):121-30. Epub 2006 Nov 28.PMID: 17131142 [PubMed - indexed for MEDLINE]Related articles

    20.

    Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase.

    Shiota C, Coffey J, Grimsby J, Grippo JF, Magnuson MA.

    J Biol Chem. 1999 Dec 24;274(52):37125-30.PMID: 10601273 [PubMed - indexed for MEDLINE]Related articlesFree article

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