PubMed

IPF1/PDX1 deficiency and beta-cell dysfunction in Psammomys obesus, an animal With type 2 diabetes.

Leibowitz G, Ferber S, Apelqvist A, Edlund H, Gross DJ, Cerasi E, Melloul D, Kaiser N.

Diabetes. 2001 Aug;50(8):1799-806.PMID: 11473041 [PubMed - indexed for MEDLINE]Related articlesFree article

beta-cell glucotoxicity in the Psammomys obesus model of type 2 diabetes.

Leibowitz G, Yuli M, Donath MY, Nesher R, Melloul D, Cerasi E, Gross DJ, Kaiser N.

Diabetes. 2001 Feb;50 Suppl 1:S113-7.PMID: 11272167 [PubMed - indexed for MEDLINE]Related articles

Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes.

Donath MY, Gross DJ, Cerasi E, Kaiser N.

Diabetes. 1999 Apr;48(4):738-44.PMID: 10102689 [PubMed - indexed for MEDLINE]Related articlesFree article

Defective glucose-regulated insulin gene expression associated with PDX-1 deficiency in the Psammomys obesus model of type 2 diabetes.

Leibowitz G, Melloul D, Yuli M, Gross DJ, Apelqvist A, Edlund H, Cerasi E, Kaiser N.

Diabetes. 2001 Feb;50 Suppl 1:S138-9. No abstract available. PMID: 11272175 [PubMed - indexed for MEDLINE]Related articles

Glucose-regulated proinsulin gene expression is required for adequate insulin production during chronic glucose exposure.

Leibowitz G, Uçkaya G, Oprescu AI, Cerasi E, Gross DJ, Kaiser N.

Endocrinology. 2002 Sep;143(9):3214-20.PMID: 12193532 [PubMed - indexed for MEDLINE]Related articlesFree article

Defective stimulus-secretion coupling in islets of Psammomys obesus, an animal model for type 2 diabetes.

Nesher R, Warwar N, Khan A, Efendic S, Cerasi E, Kaiser N.

Diabetes. 2001 Feb;50(2):308-14.PMID: 11272141 [PubMed - indexed for MEDLINE]Related articlesFree article

Interaction between genetic and dietary factors determines beta-cell function in Psammomys obesus, an animal model of type 2 diabetes.

Nesher R, Gross DJ, Donath MY, Cerasi E, Kaiser N.

Diabetes. 1999 Apr;48(4):731-7.PMID: 10102688 [PubMed - indexed for MEDLINE]Related articlesFree article

Adult rat liver cells transdifferentiated with lentiviral IPF1 vectors reverse diabetes in mice: an ex vivo gene therapy approach.

Fodor A, Harel C, Fodor L, Armoni M, Salmon P, Trono D, Karnieli E.

Diabetologia. 2007 Jan;50(1):121-30. Epub 2006 Nov 28.PMID: 17131142 [PubMed - indexed for MEDLINE]Related articles

Oligonucleotide microarray analysis reveals PDX1 as an essential regulator of mitochondrial metabolism in rat islets.

Gauthier BR, Brun T, Sarret EJ, Ishihara H, Schaad O, Descombes P, Wollheim CB.

J Biol Chem. 2004 Jul 23;279(30):31121-30. Epub 2004 May 19.PMID: 15151993 [PubMed - indexed for MEDLINE]Related articlesFree article

The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells.

Schisler JC, Jensen PB, Taylor DG, Becker TC, Knop FK, Takekawa S, German M, Weir GC, Lu D, Mirmira RG, Newgard CB.

Proc Natl Acad Sci U S A. 2005 May 17;102(20):7297-302. Epub 2005 May 9.PMID: 15883383 [PubMed - indexed for MEDLINE]Related articlesFree article

The homeodomain-interacting protein kinase 2 regulates insulin promoter factor-1/pancreatic duodenal homeobox-1 transcriptional activity.

Boucher MJ, Simoneau M, Edlund H.

Endocrinology. 2009 Jan;150(1):87-97. Epub 2008 Sep 4.PMID: 18772243 [PubMed - indexed for MEDLINE]Related articles

Insulin counteracts glucotoxic effects by suppressing thioredoxin-interacting protein production in INS-1E beta cells and in Psammomys obesus pancreatic islets.

Shaked M, Ketzinel-Gilad M, Ariav Y, Cerasi E, Kaiser N, Leibowitz G.

Diabetologia. 2009 Apr;52(4):636-44. Epub 2009 Feb 13.PMID: 19214472 [PubMed - indexed for MEDLINE]Related articles

Role of oxidative stress in pancreatic beta-cell dysfunction.

Kajimoto Y, Kaneto H.

Ann N Y Acad Sci. 2004 Apr;1011:168-76.PMID: 15126294 [PubMed - indexed for MEDLINE]Related articles

Glucose regulates islet amyloid polypeptide gene transcription in a PDX1- and calcium-dependent manner.

Macfarlane WM, Campbell SC, Elrick LJ, Oates V, Bermano G, Lindley KJ, Aynsley-Green A, Dunne MJ, James RF, Docherty K.

J Biol Chem. 2000 May 19;275(20):15330-5.PMID: 10748090 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased glucose sensitivity of stimulus-secretion coupling in islets from Psammomys obesus after diet induction of diabetes.

Pertusa JA, Nesher R, Kaiser N, Cerasi E, Henquin JC, Jonas JC.

Diabetes. 2002 Aug;51(8):2552-60.PMID: 12145170 [PubMed - indexed for MEDLINE]Related articlesFree article

beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes.

Ahlgren U, Jonsson J, Jonsson L, Simu K, Edlund H.

Genes Dev. 1998 Jun 15;12(12):1763-8.PMID: 9637677 [PubMed - indexed for MEDLINE]Related articlesFree article

Dynamic changes in {beta}-cell mass and pancreatic insulin during the evolution of nutrition-dependent diabetes in psammomys obesus: impact of glycemic control.

Kaiser N, Yuli M, Uçkaya G, Oprescu AI, Berthault MF, Kargar C, Donath MY, Cerasi E, Ktorza A.

Diabetes. 2005 Jan;54(1):138-45.PMID: 15616021 [PubMed - indexed for MEDLINE]Related articlesFree article

Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets.

Hagman DK, Latour MG, Chakrabarti SK, Fontes G, Amyot J, Tremblay C, Semache M, Lausier JA, Roskens V, Mirmira RG, Jetton TL, Poitout V.

Diabetes. 2008 Feb;57(2):424-31. Epub 2007 Nov 8.PMID: 17991758 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced insulin, GLUT2, and IDX-1 in beta-cells after partial pancreatectomy.

Zangen DH, Bonner-Weir S, Lee CH, Latimer JB, Miller CP, Habener JF, Weir GC.

Diabetes. 1997 Feb;46(2):258-64.PMID: 9000703 [PubMed - indexed for MEDLINE]Related articles

Chronic exposure of betaTC-6 cells to supraphysiologic concentrations of glucose decreases binding of the RIPE3b1 insulin gene transcription activator.

Poitout V, Olson LK, Robertson RP.

J Clin Invest. 1996 Feb 15;97(4):1041-6.PMID: 8613527 [PubMed - indexed for MEDLINE]Related articlesFree article