PubMed

Glycerol-stimulated proinsulin biosynthesis in isolated pancreatic rat islets via adenoviral-induced expression of glycerol kinase is mediated via mitochondrial metabolism.

Skelly RH, Wicksteed B, Antinozzi PA, Rhodes CJ.

Diabetes. 2001 Aug;50(8):1791-8.PMID: 11473040 [PubMed - indexed for MEDLINE]Related articlesFree article

A distinct difference in the metabolic stimulus-response coupling pathways for regulating proinsulin biosynthesis and insulin secretion that lies at the level of a requirement for fatty acyl moieties.

Skelly RH, Bollheimer LC, Wicksteed BL, Corkey BE, Rhodes CJ.

Biochem J. 1998 Apr 15;331 ( Pt 2):553-61.PMID: 9531497 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial regulation of insulin production in rat pancreatic islets.

Leibowitz G, Khaldi MZ, Shauer A, Parnes M, Oprescu AI, Cerasi E, Jonas JC, Kaiser N.

Diabetologia. 2005 Aug;48(8):1549-59. Epub 2005 Jun 29.PMID: 15986240 [PubMed - indexed for MEDLINE]Related articles

Engineering of glycerol-stimulated insulin secretion in islet beta cells. Differential metabolic fates of glucose and glycerol provide insight into mechanisms of stimulus-secretion coupling.

Noel RJ, Antinozzi PA, McGarry JD, Newgard CB.

J Biol Chem. 1997 Jul 25;272(30):18621-7.PMID: 9228030 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of mitochondrial FAD-linked glycerol-3-phosphate dehydrogenase does not correct glucose-stimulated insulin secretion from diabetic GK rat pancreatic islets.

Ueda K, Tanizawa Y, Ishihara H, Kizuki N, Ohta Y, Matsutani A, Oka Y.

Diabetologia. 1998 Jun;41(6):649-53.PMID: 9662045 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta cell: a survey of four fuel secretagogues.

Antinozzi PA, Ishihara H, Newgard CB, Wollheim CB.

J Biol Chem. 2002 Apr 5;277(14):11746-55. Epub 2002 Jan 30.PMID: 11821387 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-regulated translational control of proinsulin biosynthesis with that of the proinsulin endopeptidases PC2 and PC3 in the insulin-producing MIN6 cell line.

Skelly RH, Schuppin GT, Ishihara H, Oka Y, Rhodes CJ.

Diabetes. 1996 Jan;45(1):37-43.PMID: 8522057 [PubMed - indexed for MEDLINE]Related articles

Basal insulin hypersecretion in insulin-resistant Zucker diabetic and Zucker fatty rats: role of enhanced fuel metabolism.

Zhou YP, Cockburn BN, Pugh W, Polonsky KS.

Metabolism. 1999 Jul;48(7):857-64.PMID: 10421226 [PubMed - indexed for MEDLINE]Related articles

Syntaxin, but not soluble NSF attachment protein (SNAP), biosynthesis by rat pancreatic islets is regulated by glucose in parallel with proinsulin biosynthesis.

Nagamatsu S, Nakamichi Y, Katahira H.

Diabetologia. 1997 Dec;40(12):1396-402.PMID: 9447946 [PubMed - indexed for MEDLINE]Related articles

Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans.

Zhou YP, Grill V.

J Clin Endocrinol Metab. 1995 May;80(5):1584-90.PMID: 7745004 [PubMed - indexed for MEDLINE]Related articles

Succinate is a preferential metabolic stimulus-coupling signal for glucose-induced proinsulin biosynthesis translation.

Alarcon C, Wicksteed B, Prentki M, Corkey BE, Rhodes CJ.

Diabetes. 2002 Aug;51(8):2496-504.PMID: 12145163 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of insulin secretion and proinsulin biosynthesis by succinate.

Attali V, Parnes M, Ariav Y, Cerasi E, Kaiser N, Leibowitz G.

Endocrinology. 2006 Nov;147(11):5110-8. Epub 2006 Aug 17.PMID: 16916949 [PubMed - indexed for MEDLINE]Related articlesFree article

Cell type-specific activation of metabolism reveals that beta-cell secretion suppresses glucagon release from alpha-cells in rat pancreatic islets.

Takahashi R, Ishihara H, Tamura A, Yamaguchi S, Yamada T, Takei D, Katagiri H, Endou H, Oka Y.

Am J Physiol Endocrinol Metab. 2006 Feb;290(2):E308-16. Epub 2005 Sep 27.PMID: 16188913 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin.

Wicksteed B, Alarcon C, Briaud I, Lingohr MK, Rhodes CJ.

J Biol Chem. 2003 Oct 24;278(43):42080-90. Epub 2003 Aug 18.PMID: 12928442 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of mitochondrial Na+-Ca2+ exchanger increases mitochondrial metabolism and potentiates glucose-stimulated insulin secretion in rat pancreatic islets.

Lee B, Miles PD, Vargas L, Luan P, Glasco S, Kushnareva Y, Kornbrust ES, Grako KA, Wollheim CB, Maechler P, Olefsky JM, Anderson CM.

Diabetes. 2003 Apr;52(4):965-73.PMID: 12663468 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation.

Bollheimer LC, Skelly RH, Chester MW, McGarry JD, Rhodes CJ.

J Clin Invest. 1998 Mar 1;101(5):1094-101.PMID: 9486980 [PubMed - indexed for MEDLINE]Related articlesFree article

Exendin 4 controls insulin production in rat islet beta cells predominantly by potentiation of glucose-stimulated proinsulin biosynthesis at the translational level.

Alarcon C, Wicksteed B, Rhodes CJ.

Diabetologia. 2006 Dec;49(12):2920-9. Epub 2006 Oct 20.PMID: 17053883 [PubMed - indexed for MEDLINE]Related articles

Effects of galanin on proinsulin mRNA and insulin biosynthesis in normal islets.

Lindskog S, Gregersen S, Hermansen K, Ahrén B.

Regul Pept. 1995 Aug 22;58(3):135-9.PMID: 8577925 [PubMed - indexed for MEDLINE]Related articles

Insulin does not mediate glucose stimulation of proinsulin biosynthesis.

Leibowitz G, Oprescu AI, Uçkaya G, Gross DJ, Cerasi E, Kaiser N.

Diabetes. 2003 Apr;52(4):998-1003.PMID: 12663472 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic signals produced by purine ribonucleosides stimulate proinsulin biosynthesis and insulin secretion.

Jain K, Logothetopoulos J.

Biochem J. 1978 Mar 15;170(3):461-7.PMID: 348199 [PubMed - indexed for MEDLINE]Related articlesFree article