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    Results: 1 to 20 of 284

    1.

    Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation.

    Cnop M, Hannaert JC, Hoorens A, Eizirik DL, Pipeleers DG.

    Diabetes. 2001 Aug;50(8):1771-7.PMID: 11473037 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress.

    Kharroubi I, Ladrière L, Cardozo AK, Dogusan Z, Cnop M, Eizirik DL.

    Endocrinology. 2004 Nov;145(11):5087-96. Epub 2004 Aug 5.PMID: 15297438 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress.

    Piro S, Anello M, Di Pietro C, Lizzio MN, Patanè G, Rabuazzo AM, Vigneri R, Purrello M, Purrello F.

    Metabolism. 2002 Oct;51(10):1340-7.PMID: 12370856 [PubMed - indexed for MEDLINE]Related articles

    4.

    Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.

    Lupi R, Dotta F, Marselli L, Del Guerra S, Masini M, Santangelo C, Patané G, Boggi U, Piro S, Anello M, Bergamini E, Mosca F, Di Mario U, Del Prato S, Marchetti P.

    Diabetes. 2002 May;51(5):1437-42.PMID: 11978640 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle.

    Zhou YP, Grill VE.

    J Clin Invest. 1994 Feb;93(2):870-6.PMID: 8113418 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes.

    Shimabukuro M, Zhou YT, Levi M, Unger RH.

    Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2498-502.PMID: 9482914 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Increased lipogenic capacity of the islets of obese rats: a role in the pathogenesis of NIDDM.

    Lee Y, Hirose H, Zhou YT, Esser V, McGarry JD, Unger RH.

    Diabetes. 1997 Mar;46(3):408-13.PMID: 9032096 [PubMed - indexed for MEDLINE]Related articles

    8.

    A fatty acid-induced decrease in pyruvate dehydrogenase activity is an important determinant of beta-cell dysfunction in the obese diabetic db/db mouse.

    Zhou YP, Berggren PO, Grill V.

    Diabetes. 1996 May;45(5):580-6.PMID: 8621007 [PubMed - indexed for MEDLINE]Related articles

    9.

    Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression.

    Joseph JW, Koshkin V, Saleh MC, Sivitz WI, Zhang CY, Lowell BB, Chan CB, Wheeler MB.

    J Biol Chem. 2004 Dec 3;279(49):51049-56. Epub 2004 Sep 23.PMID: 15448158 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death.

    El-Assaad W, Buteau J, Peyot ML, Nolan C, Roduit R, Hardy S, Joly E, Dbaibo G, Rosenberg L, Prentki M.

    Endocrinology. 2003 Sep;144(9):4154-63.PMID: 12933690 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Metformin restores insulin secretion altered by chronic exposure to free fatty acids or high glucose: a direct metformin effect on pancreatic beta-cells.

    Patanè G, Piro S, Rabuazzo AM, Anello M, Vigneri R, Purrello F.

    Diabetes. 2000 May;49(5):735-40.PMID: 10905481 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Triglyceride accumulation protects against fatty acid-induced lipotoxicity.

    Listenberger LL, Han X, Lewis SE, Cases S, Farese RV Jr, Ory DS, Schaffer JE.

    Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3077-82. Epub 2003 Mar 10.PMID: 12629214 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Saturated free fatty acids and apoptosis in microvascular mesangial cells: palmitate activates pro-apoptotic signaling involving caspase 9 and mitochondrial release of endonuclease G.

    Mishra R, Simonson MS.

    Cardiovasc Diabetol. 2005 Jan 10;4(1):2.PMID: 15642122 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Inhibitory effects of fatty acids on glucose-regulated B-cell function: association with increased islet triglyceride stores and altered effect of fatty acid oxidation on glucose metabolism.

    Zhou YP, Ling ZC, Grill VE.

    Metabolism. 1996 Aug;45(8):981-6.PMID: 8769356 [PubMed - indexed for MEDLINE]Related articles

    15.

    High glucose potentiates palmitate-induced NO-mediated cytotoxicity through generation of superoxide in clonal beta-cell HIT-T15.

    Okuyama R, Fujiwara T, Ohsumi J.

    FEBS Lett. 2003 Jun 19;545(2-3):219-23.PMID: 12804779 [PubMed - indexed for MEDLINE]Related articles

    16.

    Fatty acid-induced effect on glucagon secretion is mediated via fatty acid oxidation.

    Hong J, Jeppesen PB, Nordentoft I, Hermansen K.

    Diabetes Metab Res Rev. 2007 Mar;23(3):202-10.PMID: 16802400 [PubMed - indexed for MEDLINE]Related articles

    17.

    Peroxisome proliferator-activated receptor alpha-retinoid X receptor agonists induce beta-cell protection against palmitate toxicity.

    Hellemans K, Kerckhofs K, Hannaert JC, Martens G, Van Veldhoven P, Pipeleers D.

    FEBS J. 2007 Dec;274(23):6094-105. Epub 2007 Oct 26.PMID: 17970749 [PubMed - indexed for MEDLINE]Related articles

    18.

    Troglitazone does not protect rat pancreatic beta cells against free fatty acid-induced cytotoxicity.

    Cnop M, Hannaert JC, Pipeleers DG.

    Biochem Pharmacol. 2002 Apr 1;63(7):1281-5.PMID: 11960604 [PubMed - indexed for MEDLINE]Related articles

    19.

    Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells.

    Eitel K, Staiger H, Rieger J, Mischak H, Brandhorst H, Brendel MD, Bretzel RG, Häring HU, Kellerer M.

    Diabetes. 2003 Apr;52(4):991-7.PMID: 12663471 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids.

    Briaud I, Harmon JS, Kelpe CL, Segu VB, Poitout V.

    Diabetes. 2001 Feb;50(2):315-21.PMID: 11272142 [PubMed - indexed for MEDLINE]Related articlesFree article

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