PubMed

T-cell epitope analysis on the autoantigen phogrin (IA-2beta) in the nonobese diabetic mouse.

Kelemen K, Wegmann DR, Hutton JC.

Diabetes. 2001 Aug;50(8):1729-34.PMID: 11473031 [PubMed - indexed for MEDLINE]Related articlesFree article

Spontaneous peripheral T-cell responses to the IA-2beta (phogrin) autoantigen in young nonobese diabetic mice.

Achenbach P, Kelemen K, Wegmann DR, Hutton JC.

J Autoimmun. 2002 Nov;19(3):111-6.PMID: 12419281 [PubMed - indexed for MEDLINE]Related articles

HLA-DQ8-associated T cell responses to the diabetes autoantigen phogrin (IA-2 beta) in human prediabetes.

Kelemen K, Gottlieb PA, Putnam AL, Davidson HW, Wegmann DR, Hutton JC.

J Immunol. 2004 Mar 15;172(6):3955-62.PMID: 15004204 [PubMed - indexed for MEDLINE]Related articlesFree article

Mapping of novel autoreactive epitopes of the diabetes-associated autoantigen IA-2.

Seissler J, Schott M, Morgenthaler NG, Scherbaum WA.

Clin Exp Immunol. 2000 Nov;122(2):157-63.PMID: 11091269 [PubMed - indexed for MEDLINE]Related articlesFree article

T-cell epitopes in type 1 diabetes autoantigen tyrosine phosphatase IA-2: potential for mimicry with rotavirus and other environmental agents.

Honeyman MC, Stone NL, Harrison LC.

Mol Med. 1998 Apr;4(4):231-9.PMID: 9606176 [PubMed - indexed for MEDLINE]Related articlesFree article

IA-2 (islet cell antigen 512) is the primary target of humoral autoimmunity against type 1 diabetes-associated tyrosine phosphatase autoantigens.

Bonifacio E, Lampasona V, Bingley PJ.

J Immunol. 1998 Sep 1;161(5):2648-54.PMID: 9725268 [PubMed - indexed for MEDLINE]Related articlesFree article

Cellular immune response to phogrin in the NOD mouse: cloned T-cells cause destruction of islet transplants.

Kelemen K, Crawford ML, Gill RG, Hutton JC, Wegmann D.

Diabetes. 1999 Aug;48(8):1529-34.PMID: 10426369 [PubMed - indexed for MEDLINE]Related articlesFree article

Human monoclonal antibodies isolated from type I diabetes patients define multiple epitopes in the protein tyrosine phosphatase-like IA-2 antigen.

Kolm-Litty V, Berlo S, Bonifacio E, Bearzatto M, Engel AM, Christie M, Ziegler AG, Wild T, Endl J.

J Immunol. 2000 Oct 15;165(8):4676-84.PMID: 11035111 [PubMed - indexed for MEDLINE]Related articlesFree article

Definition of multiple ICA512/phogrin autoantibody epitopes and detection of intramolecular epitope spreading in relatives of patients with type 1 diabetes.

Kawasaki E, Yu L, Rewers MJ, Hutton JC, Eisenbarth GS.

Diabetes. 1998 May;47(5):733-42.PMID: 9588444 [PubMed - indexed for MEDLINE]Related articlesFree article

Enterovirus infection can induce immune responses that cross-react with beta-cell autoantigen tyrosine phosphatase IA-2/IAR.

Härkönen T, Lankinen H, Davydova B, Hovi T, Roivainen M.

J Med Virol. 2002 Mar;66(3):340-50.PMID: 11793386 [PubMed - indexed for MEDLINE]Related articles

Early Th1 response in unprimed nonobese diabetic mice to the tyrosine phosphatase-like insulinoma-associated protein 2, an autoantigen in type 1 diabetes.

Trembleau S, Penna G, Gregori S, Magistrelli G, Isacchi A, Adorini L.

J Immunol. 2000 Dec 15;165(12):6748-55.PMID: 11120794 [PubMed - indexed for MEDLINE]Related articlesFree article

T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes.

Hawkes CJ, Schloot NC, Marks J, Willemen SJ, Drijfhout JW, Mayer EK, Christie MR, Roep BO.

Diabetes. 2000 Mar;49(3):356-66.PMID: 10868956 [PubMed - indexed for MEDLINE]Related articlesFree article

Cross reactivity between IA-2 and phogrin/IA-2beta in binding of autoantibodies in IDDM.

Hatfield EC, Hawkes CJ, Payton MA, Christie MR.

Diabetologia. 1997 Nov;40(11):1327-33.PMID: 9389426 [PubMed - indexed for MEDLINE]Related articles

Comparison of IA-2 with IA-2beta and with six other members of the protein tyrosine phosphatase family: recognition of antigenic determinants by IDDM sera.

Notkins AL, Zhang B, Matsumoto Y, Lan MS.

J Autoimmun. 1997 Jun;10(3):245-50.PMID: 9218750 [PubMed - indexed for MEDLINE]Related articles

Major DQ8-restricted T-cell epitopes for human GAD65 mapped using human CD4, DQA1*0301, DQB1*0302 transgenic IA(null) NOD mice.

Liu J, Purdy LE, Rabinovitch S, Jevnikar AM, Elliott JF.

Diabetes. 1999 Mar;48(3):469-77.PMID: 10078545 [PubMed - indexed for MEDLINE]Related articlesFree article

T cell reactivity to DR*0401- and DQ*0302-binding peptides of the putative autoantigen IA-2 in type 1 diabetes.

Lohmann T, Halder T, Engler J, Morgenthaler NG, Khoo-Morgenthaler UY, Schröder S, Seissler J, Scherbaum WA, Kalbacher H.

Exp Clin Endocrinol Diabetes. 1999;107(3):166-71.PMID: 10376440 [PubMed - indexed for MEDLINE]Related articles

Molecular cloning and characterization of the human transmembrane protein tyrosine phosphatase homologue, phogrin, an autoantigen of type 1 diabetes.

Kawasaki E, Hutton JC, Eisenbarth GS.

Biochem Biophys Res Commun. 1996 Oct 14;227(2):440-7.PMID: 8878534 [PubMed - indexed for MEDLINE]Related articles

Identification of a second transmembrane protein tyrosine phosphatase, IA-2beta, as an autoantigen in insulin-dependent diabetes mellitus: precursor of the 37-kDa tryptic fragment.

Lu J, Li Q, Xie H, Chen ZJ, Borovitskaya AE, Maclaren NK, Notkins AL, Lan MS.

Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2307-11.PMID: 8637868 [PubMed - indexed for MEDLINE]Related articlesFree article

HLA-DQ8 transgenic and NOD mice recognize different epitopes within the cytoplasmic region of the tyrosine phosphatase-like molecule, IA-2.

Kudva YC, Deng YJ, Govindarajan R, Abraham RS, Marietta EV, Notkins AL, David CS.

Hum Immunol. 2001 Oct;62(10):1099-105.PMID: 11600216 [PubMed - indexed for MEDLINE]Related articles

IDA-1, a Caenorhabditis elegans homolog of the diabetic autoantigens IA-2 and phogrin, is expressed in peptidergic neurons in the worm.

Zahn TR, Macmorris MA, Dong W, Day R, Hutton JC.

J Comp Neurol. 2001 Jan 1;429(1):127-43.PMID: 11086294 [PubMed - indexed for MEDLINE]Related articles