PubMed

Dipeptidyl peptidase IV inhibition reduces the degradation and clearance of GIP and potentiates its insulinotropic and antihyperglycemic effects in anesthetized pigs.

Deacon CF, Danielsen P, Klarskov L, Olesen M, Holst JJ.

Diabetes. 2001 Jul;50(7):1588-97.PMID: 11423480 [PubMed - indexed for MEDLINE]Related articlesFree article

Preservation of active incretin hormones by inhibition of dipeptidyl peptidase IV suppresses meal-induced incretin secretion in dogs.

Deacon CF, Wamberg S, Bie P, Hughes TE, Holst JJ.

J Endocrinol. 2002 Feb;172(2):355-62.PMID: 11834453 [PubMed - indexed for MEDLINE]Related articlesFree article

Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide 1 in the anesthetized pig.

Deacon CF, Hughes TE, Holst JJ.

Diabetes. 1998 May;47(5):764-9.PMID: 9588448 [PubMed - indexed for MEDLINE]Related articlesFree article

GIP-(3-42) does not antagonize insulinotropic effects of GIP at physiological concentrations.

Deacon CF, Plamboeck A, Rosenkilde MM, de Heer J, Holst JJ.

Am J Physiol Endocrinol Metab. 2006 Sep;291(3):E468-75. Epub 2006 Apr 11.PMID: 16608883 [PubMed - indexed for MEDLINE]Related articlesFree article

NH2-terminally modified gastric inhibitory polypeptide exhibits amino-peptidase resistance and enhanced antihyperglycemic activity.

O'Harte FP, Mooney MH, Flatt PR.

Diabetes. 1999 Apr;48(4):758-65.PMID: 10102692 [PubMed - indexed for MEDLINE]Related articlesFree article

GLP-1-(9-36) amide reduces blood glucose in anesthetized pigs by a mechanism that does not involve insulin secretion.

Deacon CF, Plamboeck A, Møller S, Holst JJ.

Am J Physiol Endocrinol Metab. 2002 Apr;282(4):E873-9.PMID: 11882507 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of dipeptidyl peptidase-4 augments insulin secretion in response to exogenously administered glucagon-like peptide-1, glucose-dependent insulinotropic polypeptide, pituitary adenylate cyclase-activating polypeptide, and gastrin-releasing peptide in mice.

Ahrén B, Hughes TE.

Endocrinology. 2005 Apr;146(4):2055-9. Epub 2004 Dec 16.PMID: 15604213 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential regional metabolism of glucagon in anesthetized pigs.

Deacon CF, Kelstrup M, Trebbien R, Klarskov L, Olesen M, Holst JJ.

Am J Physiol Endocrinol Metab. 2003 Sep;285(3):E552-60. Epub 2003 May 20.PMID: 12759222 [PubMed - indexed for MEDLINE]Related articlesFree article

Neutral endopeptidase 24.11 and dipeptidyl peptidase IV are both mediators of the degradation of glucagon-like peptide 1 in the anaesthetised pig.

Plamboeck A, Holst JJ, Carr RD, Deacon CF.

Diabetologia. 2005 Sep;48(9):1882-90. Epub 2005 Jul 16.PMID: 16025254 [PubMed - indexed for MEDLINE]Related articles

Enhanced cAMP generation and insulin-releasing potency of two novel Tyr1-modified enzyme-resistant forms of glucose-dependent insulinotropic polypeptide is associated with significant antihyperglycaemic activity in spontaneous obesity-diabetes.

Gault VA, Flatt PR, Bailey CJ, Harriott P, Greer B, Mooney MH, O'harte FP.

Biochem J. 2002 Nov 1;367(Pt 3):913-20.PMID: 12150711 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolism of glucagon-like peptide-2 in pigs: role of dipeptidyl peptidase IV.

Hansen L, Hare KJ, Hartmann B, Deacon CF, Ugleholdt RK, Plamboeck A, Holst JJ.

Regul Pept. 2007 Feb 1;138(2-3):126-32. Epub 2006 Nov 14.PMID: 17107718 [PubMed - indexed for MEDLINE]Related articles

Improved glycaemic control in obese diabetic ob/ob mice using N-terminally modified gastric inhibitory polypeptide.

O'Harte FP, Mooney MH, Kelly CM, Flatt PR.

J Endocrinol. 2000 Jun;165(3):639-48.PMID: 10828847 [PubMed - indexed for MEDLINE]Related articlesFree article

Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum.

Mentlein R, Gallwitz B, Schmidt WE.

Eur J Biochem. 1993 Jun 15;214(3):829-35.PMID: 8100523 [PubMed - indexed for MEDLINE]Related articlesFree article

Valine pyrrolidide preserves intact glucose-dependent insulinotropic peptide and improves abnormal glucose tolerance in minipigs with reduced beta-cell mass.

Larsen MO, Rolin B, Ribel U, Wilken M, Deacon CF, Svendsen O, Gotfredsen CF, Carr RD.

Exp Diabesity Res. 2003 Apr-Jun;4(2):93-105.PMID: 14630571 [PubMed - indexed for MEDLINE]Related articlesFree article

Degradation, cyclic adenosine monophosphate production, insulin secretion, and glycemic effects of two novel N-terminal Ala2-substituted analogs of glucose-dependent insulinotropic polypeptide with preserved biological activity in vivo.

Gault VA, O'Harte FP, Harriott P, Flatt PR.

Metabolism. 2003 Jun;52(6):679-87.PMID: 12800091 [PubMed - indexed for MEDLINE]Related articles

Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels after an oral glucose tolerance test in patients with type 2 diabetes.

Herman GA, Bergman A, Stevens C, Kotey P, Yi B, Zhao P, Dietrich B, Golor G, Schrodter A, Keymeulen B, Lasseter KC, Kipnes MS, Snyder K, Hilliard D, Tanen M, Cilissen C, De Smet M, de Lepeleire I, Van Dyck K, Wang AQ, Zeng W, Davies MJ, Tanaka W, Holst JJ, Deacon CF, Gottesdiener KM, Wagner JA.

J Clin Endocrinol Metab. 2006 Nov;91(11):4612-9. Epub 2006 Aug 15.PMID: 16912128 [PubMed - indexed for MEDLINE]Related articlesFree article

Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV.

Kieffer TJ, McIntosh CH, Pederson RA.

Endocrinology. 1995 Aug;136(8):3585-96.PMID: 7628397 [PubMed - indexed for MEDLINE]Related articles

Degradation of endogenous and exogenous gastric inhibitory polypeptide in healthy and in type 2 diabetic subjects as revealed using a new assay for the intact peptide.

Deacon CF, Nauck MA, Meier J, Hücking K, Holst JJ.

J Clin Endocrinol Metab. 2000 Oct;85(10):3575-81.PMID: 11061504 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulinotropic actions of nateglinide in type 2 diabetic patients and effects on dipeptidyl peptidase-IV activity and glucose-dependent insulinotropic polypeptide degradation.

McKillop AM, Duffy NA, Lindsay JR, Green BD, Patterson S, O'Harte FP, Bell PM, Flatt PR.

Eur J Endocrinol. 2009 Dec;161(6):877-85. Epub 2009 Sep 15.PMID: 19755410 [PubMed - in process]Related articles

Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors.

Hansotia T, Baggio LL, Delmeire D, Hinke SA, Yamada Y, Tsukiyama K, Seino Y, Holst JJ, Schuit F, Drucker DJ.

Diabetes. 2004 May;53(5):1326-35.PMID: 15111503 [PubMed - indexed for MEDLINE]Related articlesFree article