PubMed

Hepatocyte nuclear factor-4alpha involved in type 1 maturity-onset diabetes of the young is a novel target of AMP-activated protein kinase.

Leclerc I, Lenzner C, Gourdon L, Vaulont S, Kahn A, Viollet B.

Diabetes. 2001 Jul;50(7):1515-21.PMID: 11423471 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatocyte nuclear factor-4alpha regulates the human apolipoprotein AV gene: identification of a novel response element and involvement in the control by peroxisome proliferator-activated receptor-gamma coactivator-1alpha, AMP-activated protein kinase, and mitogen-activated protein kinase pathway.

Prieur X, Schaap FG, Coste H, Rodríguez JC.

Mol Endocrinol. 2005 Dec;19(12):3107-25. Epub 2005 Jul 28.PMID: 16051671 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatocyte nuclear factor 4alpha regulates the expression of pancreatic beta -cell genes implicated in glucose metabolism and nutrient-induced insulin secretion.

Wang H, Maechler P, Antinozzi PA, Hagenfeldt KA, Wollheim CB.

J Biol Chem. 2000 Nov 17;275(46):35953-9.PMID: 10967120 [PubMed - indexed for MEDLINE]Related articlesFree article

Genotype/phenotype relationships in HNF-4alpha/MODY1: haploinsufficiency is associated with reduced apolipoprotein (AII), apolipoprotein (CIII), lipoprotein(a), and triglyceride levels.

Shih DQ, Dansky HM, Fleisher M, Assmann G, Fajans SS, Stoffel M.

Diabetes. 2000 May;49(5):832-7.PMID: 10905494 [PubMed - indexed for MEDLINE]Related articlesFree article

The maturity-onset diabetes of the young (MODY1) transcription factor HNF4alpha regulates expression of genes required for glucose transport and metabolism.

Stoffel M, Duncan SA.

Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13209-14.PMID: 9371825 [PubMed - indexed for MEDLINE]Related articlesFree article

Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism.

Shih DQ, Screenan S, Munoz KN, Philipson L, Pontoglio M, Yaniv M, Polonsky KS, Stoffel M.

Diabetes. 2001 Nov;50(11):2472-80.PMID: 11679424 [PubMed - indexed for MEDLINE]Related articlesFree article

The 5'-AMP-activated protein kinase inhibits the transcriptional stimulation by glucose in liver cells, acting through the glucose response complex.

Leclerc I, Kahn A, Doiron B.

FEBS Lett. 1998 Jul 17;431(2):180-4.PMID: 9708898 [PubMed - indexed for MEDLINE]Related articles

Genetic evidence that HNF-1alpha-dependent transcriptional control of HNF-4alpha is essential for human pancreatic beta cell function.

Hansen SK, Párrizas M, Jensen ML, Pruhova S, Ek J, Boj SF, Johansen A, Maestro MA, Rivera F, Eiberg H, Andel M, Lebl J, Pedersen O, Ferrer J, Hansen T.

J Clin Invest. 2002 Sep;110(6):827-33.PMID: 12235114 [PubMed - indexed for MEDLINE]Related articlesFree article

The gene for hepatocyte nuclear factor (HNF)-4alpha is activated by glucocorticoids and glucagon, and repressed by insulin in rat liver.

Oyadomari S, Matsuno F, Chowdhury S, Kimura T, Iwase K, Araki E, Shichiri M, Mori M, Takiguchi M.

FEBS Lett. 2000 Jul 28;478(1-2):141-6.PMID: 10922486 [PubMed - indexed for MEDLINE]Related articles

Functional study of the E276Q mutant hepatocyte nuclear factor-4alpha found in type 1 maturity-onset diabetes of the young: impaired synergy with chicken ovalbumin upstream promoter transcription factor II on the hepatocyte nuclear factor-1 promoter.

Suaud L, Hemimou Y, Formstecher P, Laine B.

Diabetes. 1999 May;48(5):1162-7.PMID: 10331424 [PubMed - indexed for MEDLINE]Related articlesFree article

Thyroid hormone receptor interacting protein 3 (trip3) is a novel coactivator of hepatocyte nuclear factor-4alpha.

Iwahashi H, Yamagata K, Yoshiuchi I, Terasaki J, Yang Q, Fukui K, Ihara A, Zhu Q, Asakura T, Cao Y, Imagawa A, Namba M, Hanafusa T, Miyagawa J, Matsuzawa Y.

Diabetes. 2002 Apr;51(4):910-4.PMID: 11916906 [PubMed - indexed for MEDLINE]Related articlesFree article

The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion.

Gupta RK, Vatamaniuk MZ, Lee CS, Flaschen RC, Fulmer JT, Matschinsky FM, Duncan SA, Kaestner KH.

J Clin Invest. 2005 Apr;115(4):1006-15. Epub 2005 Mar 3.PMID: 15761495 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of muscle GLUT-4 transcription by AMP-activated protein kinase.

Zheng D, MacLean PS, Pohnert SC, Knight JB, Olson AL, Winder WW, Dohm GL.

J Appl Physiol. 2001 Sep;91(3):1073-83.PMID: 11509501 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of apolipoprotein M gene expression by MODY3 gene hepatocyte nuclear factor-1alpha: haploinsufficiency is associated with reduced serum apolipoprotein M levels.

Richter S, Shih DQ, Pearson ER, Wolfrum C, Fajans SS, Hattersley AT, Stoffel M.

Diabetes. 2003 Dec;52(12):2989-95.PMID: 14633861 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene expression.

da Silva Xavier G, Leclerc I, Salt IP, Doiron B, Hardie DG, Kahn A, Rutter GA.

Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4023-8.PMID: 10760274 [PubMed - indexed for MEDLINE]Related articlesFree article

A missense mutation in hepatocyte nuclear factor-4 alpha, resulting in a reduced transactivation activity, in human late-onset non-insulin-dependent diabetes mellitus.

Hani EH, Suaud L, Boutin P, Chèvre JC, Durand E, Philippi A, Demenais F, Vionnet N, Furuta H, Velho G, Bell GI, Laine B, Froguel P.

J Clin Invest. 1998 Feb 1;101(3):521-6.PMID: 9449683 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of AMP-activated protein kinase in mechanism of metformin action.

Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, Wu M, Ventre J, Doebber T, Fujii N, Musi N, Hirshman MF, Goodyear LJ, Moller DE.

J Clin Invest. 2001 Oct;108(8):1167-74.PMID: 11602624 [PubMed - indexed for MEDLINE]Related articlesFree article

Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3beta.

Shih DQ, Heimesaat M, Kuwajima S, Stein R, Wright CV, Stoffel M.

Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3818-23.PMID: 11904435 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic function in a family with a nonsense mutation (R154X) in the hepatocyte nuclear factor-4alpha/MODY1 gene.

Lindner T, Gragnoli C, Furuta H, Cockburn BN, Petzold C, Rietzsch H, Weiss U, Schulze J, Bell GI.

J Clin Invest. 1997 Sep 15;100(6):1400-5.PMID: 9294105 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP-activated protein kinase activates transcription of the UCP3 and HKII genes in rat skeletal muscle.

Stoppani J, Hildebrandt AL, Sakamoto K, Cameron-Smith D, Goodyear LJ, Neufer PD.

Am J Physiol Endocrinol Metab. 2002 Dec;283(6):E1239-48. Epub 2002 Sep 11.PMID: 12388122 [PubMed - indexed for MEDLINE]Related articlesFree article