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    Results: 1 to 20 of 186

    1.

    Transgenic overexpression of leptin rescues insulin resistance and diabetes in a mouse model of lipoatrophic diabetes.

    Ebihara K, Ogawa Y, Masuzaki H, Shintani M, Miyanaga F, Aizawa-Abe M, Hayashi T, Hosoda K, Inoue G, Yoshimasa Y, Gavrilova O, Reitman ML, Nakao K.

    Diabetes. 2001 Jun;50(6):1440-8.PMID: 11375346 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Adrenalectomy improves diabetes in A-ZIP/F-1 lipoatrophic mice by increasing both liver and muscle insulin sensitivity.

    Haluzik M, Dietz KR, Kim JK, Marcus-Samuels B, Shulman GI, Gavrilova O, Reitman ML.

    Diabetes. 2002 Jul;51(7):2113-8.PMID: 12086940 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Inhibition of the chemokine (C-C motif) ligand 2/chemokine (C-C motif) receptor 2 pathway attenuates hyperglycaemia and inflammation in a mouse model of hepatic steatosis and lipoatrophy.

    Yang SJ, IglayReger HB, Kadouh HC, Bodary PF.

    Diabetologia. 2009 May;52(5):972-81. Epub 2009 Mar 10.PMID: 19277603 [PubMed - indexed for MEDLINE]Related articles

    4.

    Beneficial effects of leptin on glycaemic and lipid control in a mouse model of type 2 diabetes with increased adiposity induced by streptozotocin and a high-fat diet.

    Kusakabe T, Tanioka H, Ebihara K, Hirata M, Miyamoto L, Miyanaga F, Hige H, Aotani D, Fujisawa T, Masuzaki H, Hosoda K, Nakao K.

    Diabetologia. 2009 Apr;52(4):675-83. Epub 2009 Jan 24.PMID: 19169663 [PubMed - indexed for MEDLINE]Related articles

    5.

    Rethinking leptin and insulin action: therapeutic opportunities for diabetes.

    Yildiz BO, Haznedaroglu IC.

    Int J Biochem Cell Biol. 2006;38(5-6):820-30. Epub 2005 Oct 3. Review.PMID: 16236542 [PubMed - indexed for MEDLINE]Related articles

    6.

    Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice.

    Gavrilova O, Marcus-Samuels B, Graham D, Kim JK, Shulman GI, Castle AL, Vinson C, Eckhaus M, Reitman ML.

    J Clin Invest. 2000 Feb;105(3):271-8.PMID: 10675352 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    A-ZIP/F-1 mice lacking white fat: a model for understanding lipoatrophic diabetes.

    Reitman ML, Gavrilova O.

    Int J Obes Relat Metab Disord. 2000 Nov;24 Suppl 4:S11-4. Review.PMID: 11126232 [PubMed - indexed for MEDLINE]Related articles

    8.

    Prevention and reversal of renal injury by leptin in a new mouse model of diabetic nephropathy.

    Suganami T, Mukoyama M, Mori K, Yokoi H, Koshikawa M, Sawai K, Hidaka S, Ebihara K, Tanaka T, Sugawara A, Kawachi H, Vinson C, Ogawa Y, Nakao K.

    FASEB J. 2005 Jan;19(1):127-9. Epub 2004 Oct 20.PMID: 15496495 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Glucose metabolism and insulin sensitivity in transgenic mice overexpressing leptin with lethal yellow agouti mutation: usefulness of leptin for the treatment of obesity-associated diabetes.

    Masuzaki H, Ogawa Y, Aizawa-Abe M, Hosoda K, Suga J, Ebihara K, Satoh N, Iwai H, Inoue G, Nishimura H, Yoshimasa Y, Nakao K.

    Diabetes. 1999 Aug;48(8):1615-22.PMID: 10426381 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Transplantation of adipose tissue lacking leptin is unable to reverse the metabolic abnormalities associated with lipoatrophy.

    Colombo C, Cutson JJ, Yamauchi T, Vinson C, Kadowaki T, Gavrilova O, Reitman ML.

    Diabetes. 2002 Sep;51(9):2727-33.PMID: 12196465 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Increased glucose metabolism and insulin sensitivity in transgenic skinny mice overexpressing leptin.

    Ogawa Y, Masuzaki H, Hosoda K, Aizawa-Abe M, Suga J, Suda M, Ebihara K, Iwai H, Matsuoka N, Satoh N, Odaka H, Kasuga H, Fujisawa Y, Inoue G, Nishimura H, Yoshimasa Y, Nakao K.

    Diabetes. 1999 Sep;48(9):1822-9.PMID: 10480614 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy.

    Shimomura I, Hammer RE, Richardson JA, Ikemoto S, Bashmakov Y, Goldstein JL, Brown MS.

    Genes Dev. 1998 Oct 15;12(20):3182-94.PMID: 9784493 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    WY14,643, a peroxisome proliferator-activated receptor alpha (PPARalpha ) agonist, improves hepatic and muscle steatosis and reverses insulin resistance in lipoatrophic A-ZIP/F-1 mice.

    Chou CJ, Haluzik M, Gregory C, Dietz KR, Vinson C, Gavrilova O, Reitman ML.

    J Biol Chem. 2002 Jul 5;277(27):24484-9. Epub 2002 May 6.PMID: 11994294 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Adrenocortical changes and arterial hypertension in lipoatrophic A-ZIP/F-1 mice.

    Lamounier-Zepter V, Bornstein SR, Kunes J, Zicha J, Krsek M, Ehrhart-Bornstein M, Ziegler CG, Kiessling A, Funk RH, Haluzik M.

    Mol Cell Endocrinol. 2008 Jan 2;280(1-2):39-46. Epub 2007 Oct 18.PMID: 18045774 [PubMed - indexed for MEDLINE]Related articles

    15.

    Hyperleptinemia precipitates diet-induced obesity in transgenic mice overexpressing leptin.

    Ogus S, Ke Y, Qiu J, Wang B, Chehab FF.

    Endocrinology. 2003 Jul;144(7):2865-9.PMID: 12810541 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Skeletal muscle AMP-activated protein kinase phosphorylation parallels metabolic phenotype in leptin transgenic mice under dietary modification.

    Tanaka T, Hidaka S, Masuzaki H, Yasue S, Minokoshi Y, Ebihara K, Chusho H, Ogawa Y, Toyoda T, Sato K, Miyanaga F, Fujimoto M, Tomita T, Kusakabe T, Kobayashi N, Tanioka H, Hayashi T, Hosoda K, Yoshimatsu H, Sakata T, Nakao K.

    Diabetes. 2005 Aug;54(8):2365-74.PMID: 16046303 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Lack of responses to a beta3-adrenergic agonist in lipoatrophic A-ZIP/F-1 mice.

    Gavrilova O, Marcus-Samuels B, Reitman ML.

    Diabetes. 2000 Nov;49(11):1910-6.PMID: 11078459 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones.

    Chao L, Marcus-Samuels B, Mason MM, Moitra J, Vinson C, Arioglu E, Gavrilova O, Reitman ML.

    J Clin Invest. 2000 Nov;106(10):1221-8.PMID: 11086023 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Activation of the hexosamine signaling pathway in adipose tissue results in decreased serum adiponectin and skeletal muscle insulin resistance.

    Hazel M, Cooksey RC, Jones D, Parker G, Neidigh JL, Witherbee B, Gulve EA, McClain DA.

    Endocrinology. 2004 May;145(5):2118-28. Epub 2003 Dec 18.PMID: 14684615 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice.

    Dentin R, Benhamed F, Hainault I, Fauveau V, Foufelle F, Dyck JR, Girard J, Postic C.

    Diabetes. 2006 Aug;55(8):2159-70.PMID: 16873678 [PubMed - indexed for MEDLINE]Related articlesFree article

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