PubMed

Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action.

Chan CB, De Leo D, Joseph JW, McQuaid TS, Ha XF, Xu F, Tsushima RG, Pennefather PS, Salapatek AM, Wheeler MB.

Diabetes. 2001 Jun;50(6):1302-10.PMID: 11375330 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of ATP production and uncoupling protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferator-activated receptor-gamma inhibition.

Patanè G, Anello M, Piro S, Vigneri R, Purrello F, Rabuazzo AM.

Diabetes. 2002 Sep;51(9):2749-56.PMID: 12196468 [PubMed - indexed for MEDLINE]Related articlesFree article

Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves beta-cell function.

Wang MY, Shimabukuro M, Lee Y, Trinh KY, Chen JL, Newgard CB, Unger RH.

Diabetes. 1999 May;48(5):1020-5.PMID: 10331406 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential effects of hyperlipidemia on insulin secretion in islets of langerhans from hyperglycemic versus normoglycemic rats.

Briaud I, Kelpe CL, Johnson LM, Tran PO, Poitout V.

Diabetes. 2002 Mar;51(3):662-8.PMID: 11872664 [PubMed - indexed for MEDLINE]Related articlesFree article

Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion?

Lameloise N, Muzzin P, Prentki M, Assimacopoulos-Jeannet F.

Diabetes. 2001 Apr;50(4):803-9.PMID: 11289045 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of short heterodimer partner recovers impaired glucose-stimulated insulin secretion of pancreatic beta-cells overexpressing UCP2.

Suh YH, Kim SY, Lee HY, Jang BC, Bae JH, Sohn JN, Bae JH, Suh SI, Park JW, Lee KU, Song DK.

J Endocrinol. 2004 Oct;183(1):133-44.PMID: 15525581 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets.

Chan CB, MacDonald PE, Saleh MC, Johns DC, Marbàn E, Wheeler MB.

Diabetes. 1999 Jul;48(7):1482-6.PMID: 10389858 [PubMed - indexed for MEDLINE]Related articlesFree article

Taurine increases glucose sensitivity of UCP2-overexpressing beta-cells by ameliorating mitochondrial metabolism.

Han J, Bae JH, Kim SY, Lee HY, Jang BC, Lee IK, Cho CH, Lim JG, Suh SI, Kwon TK, Park JW, Ryu SY, Ho WK, Earm YE, Song DK.

Am J Physiol Endocrinol Metab. 2004 Nov;287(5):E1008-18. Epub 2004 Jul 20.PMID: 15265758 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of uncoupling protein-2 up-regulation and triglyceride accumulation in impaired glucose-stimulated insulin secretion in a beta-cell lipotoxicity model overexpressing sterol regulatory element-binding protein-1c.

Yamashita T, Eto K, Okazaki Y, Yamashita S, Yamauchi T, Sekine N, Nagai R, Noda M, Kadowaki T.

Endocrinology. 2004 Aug;145(8):3566-77. Epub 2004 Apr 1.PMID: 15059954 [PubMed - indexed for MEDLINE]Related articlesFree article

cAMP-mediated signaling normalizes glucose-stimulated insulin secretion in uncoupling protein-2 overexpressing beta-cells.

McQuaid TS, Saleh MC, Joseph JW, Gyulkhandanyan A, Manning-Fox JE, MacLellan JD, Wheeler MB, Chan CB.

J Endocrinol. 2006 Sep;190(3):669-80.PMID: 17003268 [PubMed - indexed for MEDLINE]Related articlesFree article

Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression.

Joseph JW, Koshkin V, Saleh MC, Sivitz WI, Zhang CY, Lowell BB, Chan CB, Wheeler MB.

J Biol Chem. 2004 Dec 3;279(49):51049-56. Epub 2004 Sep 23.PMID: 15448158 [PubMed - indexed for MEDLINE]Related articlesFree article

PPAR-gamma overexpression selectively suppresses insulin secretory capacity in isolated pancreatic islets through induction of UCP-2 protein.

Ito E, Ozawa S, Takahashi K, Tanaka T, Katsuta H, Yamaguchi S, Maruyama M, Takizawa M, Katahira H, Yoshimoto K, Nagamatsu S, Ishida H.

Biochem Biophys Res Commun. 2004 Nov 12;324(2):810-4.PMID: 15474499 [PubMed - indexed for MEDLINE]Related articles

[Relationship between islet beta cell dysfunction and gene expression of uncoupling protein-2 and possible mechanism thereof]

Wang B, Li HL, Yang WY, Xiao JZ, Du RQ, Bai XP, Lou DJ, Pan L.

Zhonghua Yi Xue Za Zhi. 2008 Mar 4;88(9):630-4. Chinese. PMID: 18646721 [PubMed - indexed for MEDLINE]Related articles

UCP-2 and UCP-3 proteins are differentially regulated in pancreatic beta-cells.

Li Y, Maedler K, Shu L, Haataja L.

PLoS One. 2008 Jan 2;3(1):e1397.PMID: 18167556 [PubMed - indexed for MEDLINE]Related articlesFree article

Role and mechanism of rosiglitazone on the impairment of insulin secretion induced by free fatty acids on isolated rat islets.

Tian JY, Li G, Gu YY, Zhang HL, Zhou WZ, Wang X, Zhu HD, Luo TH, Luo M.

Chin Med J (Engl). 2006 Apr 5;119(7):574-80.PMID: 16620699 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreatic islets from hypothalamic obese rats maintain K+ATP channel-dependent but not -independent pathways on glucose-induced insulin release process.

Grassiolli S, Bonfleur ML, Scomparin DX, de Freitas Mathias PC.

Endocrine. 2006 Oct;30(2):191-6.PMID: 17322578 [PubMed - indexed for MEDLINE]Related articles

Peroxisome proliferator-activated receptor gamma coactivator-1-dependent uncoupling protein-2 expression in pancreatic islets of rats: a novel pathway for neural control of insulin secretion.

De Souza CT, Gasparetti AL, Pereira-da-Silva M, Araújo EP, Carvalheira JB, Saad MJ, Boschero AC, Carneiro EM, Velloso LA.

Diabetologia. 2003 Nov;46(11):1522-31. Epub 2003 Oct 24.PMID: 14576981 [PubMed - indexed for MEDLINE]Related articles

Decreased expression of t-SNARE, syntaxin 1, and SNAP-25 in pancreatic beta-cells is involved in impaired insulin secretion from diabetic GK rat islets: restoration of decreased t-SNARE proteins improves impaired insulin secretion.

Nagamatsu S, Nakamichi Y, Yamamura C, Matsushima S, Watanabe T, Ozawa S, Furukawa H, Ishida H.

Diabetes. 1999 Dec;48(12):2367-73.PMID: 10580425 [PubMed - indexed for MEDLINE]Related articlesFree article

Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction.

Krauss S, Zhang CY, Scorrano L, Dalgaard LT, St-Pierre J, Grey ST, Lowell BB.

J Clin Invest. 2003 Dec;112(12):1831-42.PMID: 14679178 [PubMed - indexed for MEDLINE]Related articlesFree article

Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets.

Zhang CY, Parton LE, Ye CP, Krauss S, Shen R, Lin CT, Porco JA Jr, Lowell BB.

Cell Metab. 2006 Jun;3(6):417-27.PMID: 16753577 [PubMed - indexed for MEDLINE]Related articles