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    Results: 1 to 20 of 244

    1.

    High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program.

    Federici M, Hribal M, Perego L, Ranalli M, Caradonna Z, Perego C, Usellini L, Nano R, Bonini P, Bertuzzi F, Marlier LN, Davalli AM, Carandente O, Pontiroli AE, Melino G, Marchetti P, Lauro R, Sesti G, Folli F.

    Diabetes. 2001 Jun;50(6):1290-301.PMID: 11375329 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress.

    Piro S, Anello M, Di Pietro C, Lizzio MN, Patanè G, Rabuazzo AM, Vigneri R, Purrello M, Purrello F.

    Metabolism. 2002 Oct;51(10):1340-7.PMID: 12370856 [PubMed - indexed for MEDLINE]Related articles

    3.

    Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets.

    Farilla L, Bulotta A, Hirshberg B, Li Calzi S, Khoury N, Noushmehr H, Bertolotto C, Di Mario U, Harlan DM, Perfetti R.

    Endocrinology. 2003 Dec;144(12):5149-58. Epub 2003 Aug 28.PMID: 12960095 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    High glucose potentiates cytokine- and streptozotocin-induced apoptosis of rat islet cells: effect on apoptosis-related genes.

    Mellado-Gil JM, Aguilar-Diosdado M.

    J Endocrinol. 2004 Oct;183(1):155-62.PMID: 15525583 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients.

    Marchetti P, Bugliani M, Lupi R, Marselli L, Masini M, Boggi U, Filipponi F, Weir GC, Eizirik DL, Cnop M.

    Diabetologia. 2007 Dec;50(12):2486-94. Epub 2007 Sep 30.PMID: 17906960 [PubMed - indexed for MEDLINE]Related articles

    6.

    The role of peripheral benzodiazepine receptors on the function and survival of isolated human pancreatic islets.

    Marselli L, Trincavelli L, Santangelo C, Lupi R, Del Guerra S, Boggi U, Falleni A, Gremigni V, Mosca F, Martini C, Dotta F, Di Mario U, Del Prato S, Marchetti P.

    Eur J Endocrinol. 2004 Aug;151(2):207-14.PMID: 15296476 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Effects of prolonged exposure to pancreatic glucagon on the function, antigenicity and survival of isolated human islets.

    Del Guerra S, Lupi R, Dotta F, Marselli L, Lencioni C, Santangelo C, Realacci M, Carmellini M, Mosca F, Navalesi R, Marchetti P.

    Diabetes Metab Res Rev. 2000 Jul-Aug;16(4):281-6.PMID: 10934457 [PubMed - indexed for MEDLINE]Related articles

    8.

    NGF-withdrawal induces apoptosis in pancreatic beta cells in vitro.

    Pierucci D, Cicconi S, Bonini P, Ferrelli F, Pastore D, Matteucci C, Marselli L, Marchetti P, Ris F, Halban P, Oberholzer J, Federici M, Cozzolino F, Lauro R, Borboni P, Marlier LN.

    Diabetologia. 2001 Oct;44(10):1281-95.PMID: 11692177 [PubMed - indexed for MEDLINE]Related articles

    9.

    Notch signalling suppresses apoptosis in adult human and mouse pancreatic islet cells.

    Dror V, Nguyen V, Walia P, Kalynyak TB, Hill JA, Johnson JD.

    Diabetologia. 2007 Dec;50(12):2504-15. Epub 2007 Oct 6.PMID: 17922104 [PubMed - indexed for MEDLINE]Related articles

    10.

    Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.

    Lupi R, Dotta F, Marselli L, Del Guerra S, Masini M, Santangelo C, Patané G, Boggi U, Piro S, Anello M, Bergamini E, Mosca F, Di Mario U, Del Prato S, Marchetti P.

    Diabetes. 2002 May;51(5):1437-42.PMID: 11978640 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets?

    Welsh N, Cnop M, Kharroubi I, Bugliani M, Lupi R, Marchetti P, Eizirik DL.

    Diabetes. 2005 Nov;54(11):3238-44.PMID: 16249450 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Transfection of human pancreatic islets with an anti-apoptotic gene (bcl-2) protects beta-cells from cytokine-induced destruction.

    Rabinovitch A, Suarez-Pinzon W, Strynadka K, Ju Q, Edelstein D, Brownlee M, Korbutt GS, Rajotte RV.

    Diabetes. 1999 Jun;48(6):1223-9.PMID: 10342808 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Specific expression of Bax-omega in pancreatic beta-cells is down-regulated by cytokines before the onset of apoptosis.

    Van de Casteele M, Kefas BA, Ling Z, Heimberg H, Pipeleers DG.

    Endocrinology. 2002 Jan;143(1):320-6.PMID: 11751624 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Ciliary neurotrophic factor promotes survival of neonatal rat islets via the BCL-2 anti-apoptotic pathway.

    Rezende LF, Stoppiglia LF, Souza KL, Negro A, Langone F, Boschero AC.

    J Endocrinol. 2007 Oct;195(1):157-65.PMID: 17911407 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Proapoptotic Bax is hyperexpressed in isolated human islets compared with antiapoptotic Bcl-2.

    Thomas D, Yang H, Boffa DJ, Ding R, Sharma VK, Lagman M, Li B, Hering B, Mohanakumar T, Lakey J, Kapur S, Hancock WW, Suthanthiran M.

    Transplantation. 2002 Dec 15;74(11):1489-96.PMID: 12490780 [PubMed - indexed for MEDLINE]Related articles

    16.

    Islet beta-cells deficient in Bcl-xL develop but are abnormally sensitive to apoptotic stimuli.

    Carrington EM, McKenzie MD, Jansen E, Myers M, Fynch S, Kos C, Strasser A, Kay TW, Scott CL, Allison J.

    Diabetes. 2009 Oct;58(10):2316-23. Epub 2009 Jul 6.PMID: 19581414 [PubMed - indexed for MEDLINE]Related articles

    17.

    Degradation of cAMP-responsive element-binding protein by the ubiquitin-proteasome pathway contributes to glucotoxicity in beta-cells and human pancreatic islets.

    Costes S, Vandewalle B, Tourrel-Cuzin C, Broca C, Linck N, Bertrand G, Kerr-Conte J, Portha B, Pattou F, Bockaert J, Dalle S.

    Diabetes. 2009 May;58(5):1105-15. Epub 2009 Feb 17.PMID: 19223597 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Proapoptotic BH3-only protein Bid is essential for death receptor-induced apoptosis of pancreatic beta-cells.

    McKenzie MD, Carrington EM, Kaufmann T, Strasser A, Huang DC, Kay TW, Allison J, Thomas HE.

    Diabetes. 2008 May;57(5):1284-92. Epub 2008 Feb 5.PMID: 18252892 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Increased islet cell proliferation, decreased apoptosis, and greater vascularization leading to beta-cell hyperplasia in mutant mice lacking insulin.

    Duvillié B, Currie C, Chrones T, Bucchini D, Jami J, Joshi RL, Hill DJ.

    Endocrinology. 2002 Apr;143(4):1530-7.PMID: 11897712 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    The diabetes-linked transcription factor PAX4 promotes {beta}-cell proliferation and survival in rat and human islets.

    Brun T, Franklin I, St-Onge L, Biason-Lauber A, Schoenle EJ, Wollheim CB, Gauthier BR.

    J Cell Biol. 2004 Dec 20;167(6):1123-35. Epub 2004 Dec 13.PMID: 15596543 [PubMed - indexed for MEDLINE]Related articlesFree article

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