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    Results: 1 to 20 of 186

    1.

    Liver-specific igf-1 gene deletion leads to muscle insulin insensitivity.

    Yakar S, Liu JL, Fernandez AM, Wu Y, Schally AV, Frystyk J, Chernausek SD, Mejia W, Le Roith D.

    Diabetes. 2001 May;50(5):1110-8.PMID: 11334415 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Insulin resistance in the liver-specific IGF-1 gene-deleted mouse is abrogated by deletion of the acid-labile subunit of the IGF-binding protein-3 complex: relative roles of growth hormone and IGF-1 in insulin resistance.

    Haluzik M, Yakar S, Gavrilova O, Setser J, Boisclair Y, LeRoith D.

    Diabetes. 2003 Oct;52(10):2483-9.PMID: 14514630 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice.

    Yakar S, Setser J, Zhao H, Stannard B, Haluzik M, Glatt V, Bouxsein ML, Kopchick JJ, LeRoith D.

    J Clin Invest. 2004 Jan;113(1):96-105.PMID: 14702113 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Age-dependent onset of liver-specific IGF-I gene deficiency and its persistence in old age: implications for postnatal growth and insulin resistance in LID mice.

    Tang Z, Yu R, Lu Y, Parlow AF, Liu JL.

    Am J Physiol Endocrinol Metab. 2005 Aug;289(2):E288-95. Epub 2005 Mar 15.PMID: 15769793 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Targeted deletion of hepatic Igf1 in TRAMP mice leads to dramatic alterations in the circulating insulin-like growth factor axis but does not reduce tumor progression.

    Anzo M, Cobb LJ, Hwang DL, Mehta H, Said JW, Yakar S, LeRoith D, Cohen P.

    Cancer Res. 2008 May 1;68(9):3342-9.PMID: 18451161 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    A model for tissue-specific inducible insulin-like growth factor-I (IGF-I) inactivation to determine the physiological role of liver-derived IGF-I.

    Sjögren K, Jansson JO, Isaksson OG, Ohlsson C.

    Endocrine. 2002 Dec;19(3):249-56. Review.PMID: 12624424 [PubMed - indexed for MEDLINE]Related articles

    7.

    A transgenic model to determine the physiological role of liver-derived insulin-like growth factor I.

    Sjögren K, Jansson JO, Isaksson OG, Ohlsson C.

    Minerva Endocrinol. 2002 Dec;27(4):299-311. Review.PMID: 12511852 [PubMed - indexed for MEDLINE]Related articles

    8.

    Growth hormone receptor gene deficiency causes delayed insulin responsiveness in skeletal muscles without affecting compensatory islet cell overgrowth in obese mice.

    Robertson K, Kopchick JJ, Liu JL.

    Am J Physiol Endocrinol Metab. 2006 Sep;291(3):E491-8. Epub 2006 Apr 18.PMID: 16621895 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Liver-specific overexpression of the insulin-like growth factor-I enhances somatic growth and partially prevents the effects of growth hormone deficiency.

    Liao L, Dearth RK, Zhou S, Britton OL, Lee AV, Xu J.

    Endocrinology. 2006 Aug;147(8):3877-88. Epub 2006 May 18.PMID: 16709615 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Suppressor of cytokine signaling-2 deficiency induces molecular and metabolic changes that partially overlap with growth hormone-dependent effects.

    Rico-Bautista E, Greenhalgh CJ, Tollet-Egnell P, Hilton DJ, Alexander WS, Norstedt G, Flores-Morales A.

    Mol Endocrinol. 2005 Mar;19(3):781-93. Epub 2004 Nov 24.PMID: 15563548 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Pancreatic islet-specific expression of an insulin-like growth factor-I transgene compensates islet cell growth in growth hormone receptor gene-deficient mice.

    Guo Y, Lu Y, Houle D, Robertson K, Tang Z, Kopchick JJ, Liu YL, Liu JL.

    Endocrinology. 2005 Jun;146(6):2602-9. Epub 2005 Feb 24.PMID: 15731363 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Mice deficient in liver production of insulin-like growth factor I display sexual dimorphism in growth hormone-stimulated postnatal growth.

    Liu JL, Yakar S, LeRoith D.

    Endocrinology. 2000 Dec;141(12):4436-41.PMID: 11108252 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling.

    Withers DJ, Burks DJ, Towery HH, Altamuro SL, Flint CL, White MF.

    Nat Genet. 1999 Sep;23(1):32-40.PMID: 10471495 [PubMed - indexed for MEDLINE]Related articles

    14.

    GH regulation of IGF-I and suppressor of cytokine signaling gene expression in C2C12 skeletal muscle cells.

    Sadowski CL, Wheeler TT, Wang LH, Sadowski HB.

    Endocrinology. 2001 Sep;142(9):3890-900.PMID: 11517167 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Serum IGF-I-deficiency does not prevent compensatory skeletal muscle hypertrophy in resistance exercise.

    Matheny RW, Merritt E, Zannikos SV, Farrar RP, Adamo ML.

    Exp Biol Med (Maywood). 2009 Feb;234(2):164-70. Epub 2008 Dec 8. Erratum in: Exp Biol Med (Maywood). 2009 Oct;234(10):1. Matheny, Wayne [corrected to Matheny, Ronald W]. PMID: 19064939 [PubMed - indexed for MEDLINE]Related articles

    16.

    Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess.

    Barbour LA, Mizanoor Rahman S, Gurevich I, Leitner JW, Fischer SJ, Roper MD, Knotts TA, Vo Y, McCurdy CE, Yakar S, Leroith D, Kahn CR, Cantley LC, Friedman JE, Draznin B.

    J Biol Chem. 2005 Nov 11;280(45):37489-94. Epub 2005 Sep 8.PMID: 16166093 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Studies involving the GH-IGF axis: Lessons from IGF-I and IGF-I receptor gene targeting mouse models.

    Yakar S, Pennisi P, Kim CH, Zhao H, Toyoshima Y, Gavrilova O, LeRoith D.

    J Endocrinol Invest. 2005;28(5 Suppl):19-22. Review.PMID: 16114270 [PubMed - indexed for MEDLINE]Related articles

    18.

    Short-term low-dose growth hormone administration in subjects with impaired glucose tolerance and the metabolic syndrome: effects on beta-cell function and post-load glucose tolerance.

    Yuen K, Wareham N, Frystyk J, Hennings S, Mitchell J, Fryklund L, Dunger D.

    Eur J Endocrinol. 2004 Jul;151(1):39-45.PMID: 15248820 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Recombinant human insulin-like growth factor-I treatment inhibits gluconeogenesis in a transgenic mouse model of type 2 diabetes mellitus.

    Pennisi P, Gavrilova O, Setser-Portas J, Jou W, Santopietro S, Clemmons D, Yakar S, LeRoith D.

    Endocrinology. 2006 Jun;147(6):2619-30. Epub 2006 Mar 2.PMID: 16513827 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis.

    Wu Y, Yakar S, Zhao L, Hennighausen L, LeRoith D.

    Cancer Res. 2002 Feb 15;62(4):1030-5.PMID: 11861378 [PubMed - indexed for MEDLINE]Related articlesFree article

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