PubMed

Pioglitazone ameliorates tumor necrosis factor-alpha-induced insulin resistance by a mechanism independent of adipogenic activity of peroxisome proliferator--activated receptor-gamma.

Iwata M, Haruta T, Usui I, Takata Y, Takano A, Uno T, Kawahara J, Ueno E, Sasaoka T, Ishibashi O, Kobayashi M.

Diabetes. 2001 May;50(5):1083-92.PMID: 11334412 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of peroxisome proliferator-activated receptor-gamma in maintenance of the characteristics of mature 3T3-L1 adipocytes.

Tamori Y, Masugi J, Nishino N, Kasuga M.

Diabetes. 2002 Jul;51(7):2045-55.PMID: 12086932 [PubMed - indexed for MEDLINE]Related articlesFree article

Growth hormone induces cellular insulin resistance by uncoupling phosphatidylinositol 3-kinase and its downstream signals in 3T3-L1 adipocytes.

Takano A, Haruta T, Iwata M, Usui I, Uno T, Kawahara J, Ueno E, Sasaoka T, Kobayashi M.

Diabetes. 2001 Aug;50(8):1891-900.PMID: 11473053 [PubMed - indexed for MEDLINE]Related articlesFree article

Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling.

Peraldi P, Xu M, Spiegelman BM.

J Clin Invest. 1997 Oct 1;100(7):1863-9.PMID: 9312188 [PubMed - indexed for MEDLINE]Related articlesFree article

A selective peroxisome proliferator-activated receptor-gamma (PPARgamma) modulator blocks adipocyte differentiation but stimulates glucose uptake in 3T3-L1 adipocytes.

Mukherjee R, Hoener PA, Jow L, Bilakovics J, Klausing K, Mais DE, Faulkner A, Croston GE, Paterniti JR Jr.

Mol Endocrinol. 2000 Sep;14(9):1425-33.PMID: 10976920 [PubMed - indexed for MEDLINE]Related articlesFree article

Tumor necrosis factor-alpha causes insulin receptor substrate-2-mediated insulin resistance and inhibits insulin-induced adipogenesis in fetal brown adipocytes.

Valverde AM, Teruel T, Navarro P, Benito M, Lorenzo M.

Endocrinology. 1998 Mar;139(3):1229-38.PMID: 9492058 [PubMed - indexed for MEDLINE]Related articlesFree article

The G972R variant of the insulin receptor substrate-1 gene impairs insulin signaling and cell differentiation in 3T3L1 adipocytes; treatment with a PPARgamma agonist restores normal cell signaling and differentiation.

Sentinelli F, Filippi E, Cavallo MG, Romeo S, Fanelli M, Baroni MG.

J Endocrinol. 2006 Feb;188(2):271-85.PMID: 16461553 [PubMed - indexed for MEDLINE]Related articlesFree article

Possibility of distinct insulin-signaling pathways beyond phosphatidylinositol 3-kinase-mediating glucose transport and lipogenesis.

Stevenson RW, Kreutter DK, Andrews KM, Genereux PE, Gibbs EM.

Diabetes. 1998 Feb;47(2):179-85.PMID: 9519710 [PubMed - indexed for MEDLINE]Related articles

Tumor necrosis factor alpha-mediated insulin resistance, but not dedifferentiation, is abrogated by MEK1/2 inhibitors in 3T3-L1 adipocytes.

Engelman JA, Berg AH, Lewis RY, Lisanti MP, Scherer PE.

Mol Endocrinol. 2000 Oct;14(10):1557-69.PMID: 11043572 [PubMed - indexed for MEDLINE]Related articlesFree article

Essential role of insulin-like growth factor I receptor in insulin-induced fetal brown adipocyte differentiation.

Mur C, Arribas M, Benito M, Valverde AM.

Endocrinology. 2003 Feb;144(2):581-93.PMID: 12538620 [PubMed - indexed for MEDLINE]Related articlesFree article

YM268 increases the glucose uptake, cell differentiation, and mRNA expression of glucose transporter in 3T3-L1 adipocytes.

Shimaya A, Kurosaki E, Shioduka K, Nakano R, Shibasaki M, Shikama H.

Horm Metab Res. 1998 Sep;30(9):543-8.PMID: 9808320 [PubMed - indexed for MEDLINE]Related articles

Tumor necrosis factor promotes phosphorylation and binding of insulin receptor substrate 1 to phosphatidylinositol 3-kinase in 3T3-L1 adipocytes.

Guo D, Donner DB.

J Biol Chem. 1996 Jan 12;271(2):615-8.PMID: 8557661 [PubMed - indexed for MEDLINE]Related articlesFree article

The expression of the p85alpha subunit of phosphatidylinositol 3-kinase is induced by activation of the peroxisome proliferator-activated receptor gamma in human adipocytes.

Rieusset J, Chambrier C, Bouzakri K, Dusserre E, Auwerx J, Riou JP, Laville M, Vidal H.

Diabetologia. 2001 May;44(5):544-54.PMID: 11380072 [PubMed - indexed for MEDLINE]Related articles

Antidiabetic thiazolidinediones block the inhibitory effect of tumor necrosis factor-alpha on differentiation, insulin-stimulated glucose uptake, and gene expression in 3T3-L1 cells.

Szalkowski D, White-Carrington S, Berger J, Zhang B.

Endocrinology. 1995 Apr;136(4):1474-81.PMID: 7895657 [PubMed - indexed for MEDLINE]Related articles

Tumor necrosis factor-alpha and ceramides in insulin resistance.

Brindley DN, Wang CN, Mei J, Xu J, Hanna AN.

Lipids. 1999;34 Suppl:S85-8.PMID: 10419100 [PubMed - indexed for MEDLINE]Related articles

Essential role of insulin receptor substrate 1 in differentiation of brown adipocytes.

Fasshauer M, Klein J, Kriauciunas KM, Ueki K, Benito M, Kahn CR.

Mol Cell Biol. 2001 Jan;21(1):319-29.PMID: 11113206 [PubMed - indexed for MEDLINE]Related articlesFree article

Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects.

Rotter V, Nagaev I, Smith U.

J Biol Chem. 2003 Nov 14;278(46):45777-84. Epub 2003 Sep 2.PMID: 12952969 [PubMed - indexed for MEDLINE]Related articlesFree article

BRL 49653 blocks the lipolytic actions of tumor necrosis factor-alpha: a potential new insulin-sensitizing mechanism for thiazolidinediones.

Souza SC, Yamamoto MT, Franciosa MD, Lien P, Greenberg AS.

Diabetes. 1998 Apr;47(4):691-5.PMID: 9568706 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of pioglitazone on suppressor of cytokine signaling 3 expression: potential mechanisms for its effects on insulin sensitivity and adiponectin expression.

Kanatani Y, Usui I, Ishizuka K, Bukhari A, Fujisaka S, Urakaze M, Haruta T, Kishimoto T, Naka T, Kobayashi M.

Diabetes. 2007 Mar;56(3):795-803.PMID: 17327450 [PubMed - indexed for MEDLINE]Related articlesFree article

Tumor necrosis factor-alpha suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes: nuclear factor-kappaB activation by TNF-alpha is obligatory.

Ruan H, Hacohen N, Golub TR, Van Parijs L, Lodish HF.

Diabetes. 2002 May;51(5):1319-36.PMID: 11978627 [PubMed - indexed for MEDLINE]Related articlesFree article