PubMed

Beta-cell mass dynamics in Zucker diabetic fatty rats. Rosiglitazone prevents the rise in net cell death.

Finegood DT, McArthur MD, Kojwang D, Thomas MJ, Topp BG, Leonard T, Buckingham RE.

Diabetes. 2001 May;50(5):1021-9.PMID: 11334404 [PubMed - indexed for MEDLINE]Related articlesFree article

Rosiglitazone prevents the onset of hyperglycaemia and proteinuria in the Zucker diabetic fatty rat.

Smith SA, Lister CA, Toseland CD, Buckingham RE.

Diabetes Obes Metab. 2000 Dec;2(6):363-72.PMID: 11225966 [PubMed - indexed for MEDLINE]Related articles

Down-regulation of orexin gene expression by severe obesity in the rats: studies in Zucker fatty and zucker diabetic fatty rats and effects of rosiglitazone.

Cai XJ, Lister CA, Buckingham RE, Pickavance L, Wilding J, Arch JR, Wilson S, Williams G.

Brain Res Mol Brain Res. 2000 Apr 14;77(1):131-7.PMID: 10814839 [PubMed - indexed for MEDLINE]Related articles

Improved metabolic status and insulin sensitivity in obese fatty (fa/fa) Zucker rats and Zucker Diabetic Fatty (ZDF) rats treated with the thiazolidinedione, MCC-555.

Upton R, Widdowson PS, Ishii S, Tanaka H, Williams G.

Br J Pharmacol. 1998 Dec;125(8):1708-14.PMID: 9886762 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulation of adipoinsular axis in prediabetic zucker diabetic fatty rats by diazoxide.

Alemzadeh R, Tushaus KM.

Endocrinology. 2004 Dec;145(12):5476-84. Epub 2004 Aug 19.PMID: 15319354 [PubMed - indexed for MEDLINE]Related articlesFree article

A nonspecific phosphotyrosine phosphatase inhibitor, bis(maltolato)oxovanadium(IV), improves glucose tolerance and prevents diabetes in Zucker diabetic fatty rats.

Winter CL, Lange JS, Davis MG, Gerwe GS, Downs TR, Peters KG, Kasibhatla B.

Exp Biol Med (Maywood). 2005 Mar;230(3):207-16.PMID: 15734724 [PubMed - indexed for MEDLINE]Related articlesFree article

Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes.

Shimabukuro M, Zhou YT, Levi M, Unger RH.

Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2498-502.PMID: 9482914 [PubMed - indexed for MEDLINE]Related articlesFree article

Improvement of glucose tolerance in Zucker diabetic fatty rats by long-term treatment with the dipeptidyl peptidase inhibitor P32/98: comparison with and combination with rosiglitazone.

Wargent E, Stocker C, Augstein P, Heinke P, Meyer A, Hoffmann T, Subramanian A, Sennitt MV, Demuth HU, Arch JR, Cawthorne MA.

Diabetes Obes Metab. 2005 Mar;7(2):170-81.PMID: 15715890 [PubMed - indexed for MEDLINE]Related articles

Defective fatty acid-mediated beta-cell compensation in Zucker diabetic fatty rats. Pathogenic implications for obesity-dependent diabetes.

Hirose H, Lee YH, Inman LR, Nagasawa Y, Johnson JH, Unger RH.

J Biol Chem. 1996 Mar 8;271(10):5633-7.PMID: 8621426 [PubMed - indexed for MEDLINE]Related articlesFree article

The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects.

Yu JG, Javorschi S, Hevener AL, Kruszynska YT, Norman RA, Sinha M, Olefsky JM.

Diabetes. 2002 Oct;51(10):2968-74.PMID: 12351435 [PubMed - indexed for MEDLINE]Related articlesFree article

Troglitazone prevents and reverses dyslipidemia, insulin secretory defects, and histologic abnormalities in a rat model of naturally occurring obese diabetes.

Jia DM, Tabaru A, Nakamura H, Fukumitsu KI, Akiyama T, Otsuki M.

Metabolism. 2000 Sep;49(9):1167-75.PMID: 11016899 [PubMed - indexed for MEDLINE]Related articles

Differences in plasma homocysteine levels between Zucker fatty and Zucker diabetic fatty rats following 3 weeks oral administration of organic vanadium compounds.

Wasan KM, Risovic V, Yuen VG, McNeill JH.

J Trace Elem Med Biol. 2006;19(4):251-8. Epub 2005 Dec 13.PMID: 16443173 [PubMed - indexed for MEDLINE]Related articles

Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat.

Pick A, Clark J, Kubstrup C, Levisetti M, Pugh W, Bonner-Weir S, Polonsky KS.

Diabetes. 1998 Mar;47(3):358-64.PMID: 9519740 [PubMed - indexed for MEDLINE]Related articlesFree article

Attenuation of type 2 diabetes mellitus in the male Zucker diabetic fatty rat: the effects of stress and non-volitional exercise.

Király MA, Bates HE, Yue JT, Goche-Montes D, Fediuc S, Park E, Matthews SG, Vranic M, Riddell MC.

Metabolism. 2007 Jun;56(6):732-44.PMID: 17512304 [PubMed - indexed for MEDLINE]Related articles

Phlorizin treatment prevents the decrease in plasma insulin levels but not the progressive histopathological changes in the pancreatic islets during aging of Zucker diabetic fatty rats.

Janssen SW, Martens GJ, Sweep CG, Span PN, Verhofstad AA, Hermus AR.

J Endocrinol Invest. 2003 Jun;26(6):508-15.PMID: 12952363 [PubMed - indexed for MEDLINE]Related articles

Changes in islet capillary angioarchitecture coincide with impaired B-cell function but not with insulin resistance in male Otsuka-Long-Evans-Tokushima fatty rats: dimorphism of the diabetic phenotype at an advanced age.

Mizuno A, Noma Y, Kuwajima M, Murakami T, Zhu M, Shima K.

Metabolism. 1999 Apr;48(4):477-83.PMID: 10206441 [PubMed - indexed for MEDLINE]Related articles

Therapeutic index for rosiglitazone in dietary obese rats: separation of efficacy and haemodilution.

Pickavance LC, Tadayyon M, Widdowson PS, Buckingham RE, Wilding JP.

Br J Pharmacol. 1999 Dec;128(7):1570-6.PMID: 10602338 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of chronic rosiglitazone, metformin and glyburide treatment on beta-cell mass, function and insulin sensitivity in mZDF rats.

Atkinson LL, McDonald-Dyck C, Benkoczi C, Finegood DT.

Diabetes Obes Metab. 2008 Sep;10(9):780-90. Epub 2007 Oct 26.PMID: 17970758 [PubMed - indexed for MEDLINE]Related articles

Effect of partial pancreatectomy on beta-cell mass in the remnant pancreas of Wistar fatty rats.

Ogino T, Zhu M, Murakami T, Kuwajima M, Shima K.

J Med Invest. 1998 Aug;45(1-4):103-10.PMID: 9864970 [PubMed - indexed for MEDLINE]Related articles

Lipid-induced beta-cell dysfunction in vivo in models of progressive beta-cell failure.

Goh TT, Mason TM, Gupta N, So A, Lam TK, Lam L, Lewis GF, Mari A, Giacca A.

Am J Physiol Endocrinol Metab. 2007 Feb;292(2):E549-60. Epub 2006 Sep 26.PMID: 17003242 [PubMed - indexed for MEDLINE]Related articlesFree article