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    Results: 1 to 20 of 229

    1.

    Differential splicing of the IA-2 mRNA in pancreas and lymphoid organs as a permissive genetic mechanism for autoimmunity against the IA-2 type 1 diabetes autoantigen.

    Diez J, Park Y, Zeller M, Brown D, Garza D, Ricordi C, Hutton J, Eisenbarth GS, Pugliese A.

    Diabetes. 2001 Apr;50(4):895-900.PMID: 11289059 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Alternative splicing of G6PC2, the gene coding for the islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP), results in differential expression in human thymus and spleen compared with pancreas.

    Dogra RS, Vaidyanathan P, Prabakar KR, Marshall KE, Hutton JC, Pugliese A.

    Diabetologia. 2006 May;49(5):953-7. Epub 2006 Mar 7.PMID: 16520917 [PubMed - indexed for MEDLINE]Related articles

    3.

    IA-2 (islet cell antigen 512) is the primary target of humoral autoimmunity against type 1 diabetes-associated tyrosine phosphatase autoantigens.

    Bonifacio E, Lampasona V, Bingley PJ.

    J Immunol. 1998 Sep 1;161(5):2648-54.PMID: 9725268 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    T-cell epitopes in type 1 diabetes autoantigen tyrosine phosphatase IA-2: potential for mimicry with rotavirus and other environmental agents.

    Honeyman MC, Stone NL, Harrison LC.

    Mol Med. 1998 Apr;4(4):231-9.PMID: 9606176 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs.

    Pugliese A, Brown D, Garza D, Murchison D, Zeller M, Redondo MJ, Diez J, Eisenbarth GS, Patel DD, Ricordi C.

    J Clin Invest. 2001 Mar;107(5):555-64. Erratum in: J Clin Invest. 2006 Feb;116(2):548. Redondo, M [corrected to Redondo, MJ]. PMID: 11238556 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Humoral autoreactivity to an alternatively spliced variant of ICA512/IA-2 in Type I diabetes.

    Park YS, Kawasaki E, Kelemen K, Yu L, Schiller MR, Rewers M, Mizuta M, Eisenbarth GS, Hutton JC.

    Diabetologia. 2000 Oct;43(10):1293-301.PMID: 11079748 [PubMed - indexed for MEDLINE]Related articles

    7.

    T-cell mediated autoimmunity to the insulinoma-associated protein 2 islet tyrosine phosphatase in type 1 diabetes mellitus.

    Dotta F, Dionisi S, Viglietta V, Tiberti C, Matteoli MC, Cervoni M, Bizzarri C, Marietti G, Testi M, Multari G, Lucentini L, Di Mario U.

    Eur J Endocrinol. 1999 Sep;141(3):272-8.PMID: 10474125 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Autoantibodies in insulin-dependent diabetes recognize distinct cytoplasmic domains of the protein tyrosine phosphatase-like IA-2 autoantigen.

    Lampasona V, Bearzatto M, Genovese S, Bosi E, Ferrari M, Bonifacio E.

    J Immunol. 1996 Sep 15;157(6):2707-11.PMID: 8805677 [PubMed - indexed for MEDLINE]Related articles

    9.

    Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens.

    Bearzatto M, Naserke H, Piquer S, Koczwara K, Lampasona V, Williams A, Christie MR, Bingley PJ, Ziegler AG, Bonifacio E.

    J Immunol. 2002 Apr 15;168(8):4202-8.PMID: 11937581 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Human monoclonal antibodies isolated from type I diabetes patients define multiple epitopes in the protein tyrosine phosphatase-like IA-2 antigen.

    Kolm-Litty V, Berlo S, Bonifacio E, Bearzatto M, Engel AM, Christie M, Ziegler AG, Wild T, Endl J.

    J Immunol. 2000 Oct 15;165(8):4676-84.PMID: 11035111 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Mapping of novel autoreactive epitopes of the diabetes-associated autoantigen IA-2.

    Seissler J, Schott M, Morgenthaler NG, Scherbaum WA.

    Clin Exp Immunol. 2000 Nov;122(2):157-63.PMID: 11091269 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Early Th1 response in unprimed nonobese diabetic mice to the tyrosine phosphatase-like insulinoma-associated protein 2, an autoantigen in type 1 diabetes.

    Trembleau S, Penna G, Gregori S, Magistrelli G, Isacchi A, Adorini L.

    J Immunol. 2000 Dec 15;165(12):6748-55.PMID: 11120794 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Autoantigens in insulin-dependent diabetes mellitus: molecular cloning and characterization of human IA-2 beta.

    Li Q, Borovitskaya AE, DeSilva MG, Wasserfall C, Maclaren NK, Notkins AL, Lan MS.

    Proc Assoc Am Physicians. 1997 Jul;109(4):429-39.PMID: 9220540 [PubMed - indexed for MEDLINE]Related articles

    14.

    Autoimmune diabetes: the role of T cells, MHC molecules and autoantigens.

    Durinovic-Belló I.

    Autoimmunity. 1998;27(3):159-77. Review.PMID: 9609134 [PubMed - indexed for MEDLINE]Related articles

    15.

    Identification of a second transmembrane protein tyrosine phosphatase, IA-2beta, as an autoantigen in insulin-dependent diabetes mellitus: precursor of the 37-kDa tryptic fragment.

    Lu J, Li Q, Xie H, Chen ZJ, Borovitskaya AE, Maclaren NK, Notkins AL, Lan MS.

    Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2307-11.PMID: 8637868 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes.

    Hawkes CJ, Schloot NC, Marks J, Willemen SJ, Drijfhout JW, Mayer EK, Christie MR, Roep BO.

    Diabetes. 2000 Mar;49(3):356-66.PMID: 10868956 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Early development and spreading of autoantibodies to epitopes of IA-2 and their association with progression to type 1 diabetes.

    Naserke HE, Ziegler AG, Lampasona V, Bonifacio E.

    J Immunol. 1998 Dec 15;161(12):6963-9.PMID: 9862731 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Detection of proteolytic cleavages of diabetes-associated protein IA-2 beta in the pancreas and the brain using novel anti-IA-2 beta monoclonal antibodies.

    Kawakami T, Saeki K, Takeyama N, Wu G, Sakudo A, Matsumoto Y, Hayashi T, Onodera T.

    Int J Mol Med. 2007 Aug;20(2):177-85.PMID: 17611635 [PubMed - indexed for MEDLINE]Related articles

    19.

    IDA-1, a Caenorhabditis elegans homolog of the diabetic autoantigens IA-2 and phogrin, is expressed in peptidergic neurons in the worm.

    Zahn TR, Macmorris MA, Dong W, Day R, Hutton JC.

    J Comp Neurol. 2001 Jan 1;429(1):127-43.PMID: 11086294 [PubMed - indexed for MEDLINE]Related articles

    20.

    Immunization of HLA class I transgenic mice identifies autoantigenic epitopes eliciting dominant responses in type 1 diabetes patients.

    Blancou P, Mallone R, Martinuzzi E, Sévère S, Pogu S, Novelli G, Bruno G, Charbonnel B, Dolz M, Chaillous L, van Endert P, Bach JM.

    J Immunol. 2007 Jun 1;178(11):7458-66.PMID: 17513797 [PubMed - indexed for MEDLINE]Related articlesFree article

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