PubMed

The Gly972Arg polymorphism in the insulin receptor substrate-1 gene contributes to the variation in insulin secretion in normal glucose-tolerant humans.

Stumvoll M, Fritsche A, Volk A, Stefan N, Madaus A, Maerker E, Teigeler A, Koch M, Machicao F, Häring H.

Diabetes. 2001 Apr;50(4):882-5.PMID: 11289056 [PubMed - indexed for MEDLINE]Related articlesFree article

The Gly972-->Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic beta cells.

Porzio O, Federici M, Hribal ML, Lauro D, Accili D, Lauro R, Borboni P, Sesti G.

J Clin Invest. 1999 Aug;104(3):357-64.PMID: 10430617 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin secretory function is impaired in isolated human islets carrying the Gly(972)-->Arg IRS-1 polymorphism.

Marchetti P, Lupi R, Federici M, Marselli L, Masini M, Boggi U, Del Guerra S, Patanè G, Piro S, Anello M, Bergamini E, Purrello F, Lauro R, Mosca F, Sesti G, Del Prato S.

Diabetes. 2002 May;51(5):1419-24.PMID: 11978638 [PubMed - indexed for MEDLINE]Related articlesFree article

The prevalent Gly1057Asp polymorphism in the insulin receptor substrate-2 gene is not associated with impaired insulin secretion.

Fritsche A, Madaus A, Renn W, Tschritter O, Teigeler A, Weisser M, Maerker E, Machicao F, Häring H, Stumvoll M.

J Clin Endocrinol Metab. 2001 Oct;86(10):4822-5.PMID: 11600548 [PubMed - indexed for MEDLINE]Related articlesFree article

Interaction effect between common polymorphisms in PPARgamma2 (Pro12Ala) and insulin receptor substrate 1 (Gly972Arg) on insulin sensitivity.

Stumvoll M, Stefan N, Fritsche A, Madaus A, Tschritter O, Koch M, Machicao F, Häring H.

J Mol Med. 2002 Jan;80(1):33-8. Epub 2001 Sep 15.PMID: 11862322 [PubMed - indexed for MEDLINE]Related articles

Amino acid polymorphism Gly 972 Arg in IRS-1 is not associated to lower clamp-derived insulin sensitivity in young healthy first degree relatives of patients with type 2 diabetes.

Koch M, Rett K, Volk A, Maerker E, Haist K, Deninger M, Renn W, Häring HU.

Exp Clin Endocrinol Diabetes. 1999;107(5):318-22.PMID: 10482045 [PubMed - indexed for MEDLINE]Related articles

Metabolic effects of the Gly1057Asp polymorphism in IRS-2 and interactions with obesity.

Stefan N, Kovacs P, Stumvoll M, Hanson RL, Lehn-Stefan A, Permana PA, Baier LJ, Tataranni PA, Silver K, Bogardus C.

Diabetes. 2003 Jun;52(6):1544-50.PMID: 12765968 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired beta-cell function, incretin effect, and glucagon suppression in patients with type 1 diabetes who have normal fasting glucose.

Greenbaum CJ, Prigeon RL, D'Alessio DA.

Diabetes. 2002 Apr;51(4):951-7.PMID: 11916912 [PubMed - indexed for MEDLINE]Related articlesFree article

Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease.

Terauchi Y, Iwamoto K, Tamemoto H, Komeda K, Ishii C, Kanazawa Y, Asanuma N, Aizawa T, Akanuma Y, Yasuda K, Kodama T, Tobe K, Yazaki Y, Kadowaki T.

J Clin Invest. 1997 Mar 1;99(5):861-6.PMID: 9062343 [PubMed - indexed for MEDLINE]Related articlesFree article

Search for variants of the gene-promoter and the potential phosphotyrosine encoding sequence of the insulin receptor substrate-2 gene: evaluation of their relation with alterations in insulin secretion and insulin sensitivity.

Almind K, Frederiksen SK, Bernal D, Hansen T, Ambye L, Urhammer S, Ekstrøm CT, Berglund L, Reneland R, Lithell H, White MF, Van Obberghen E, Pedersen O.

Diabetologia. 1999 Oct;42(10):1244-9.PMID: 10525667 [PubMed - indexed for MEDLINE]Related articles

Polymorphisms of insulin receptor substrate 1 and beta3-adrenergic receptor genes in gestational diabetes and normal pregnancy.

Fallucca F, Dalfrà MG, Sciullo E, Masin M, Buongiorno AM, Napoli A, Fedele D, Lapolla A.

Metabolism. 2006 Nov;55(11):1451-6.PMID: 17046546 [PubMed - indexed for MEDLINE]Related articles

Functional significance of the UCSNP-43 polymorphism in the CAPN10 gene for proinsulin processing and insulin secretion in nondiabetic Germans.

Stumvoll M, Fritsche A, Madaus A, Stefan N, Weisser M, Machicao F, Häring H.

Diabetes. 2001 Sep;50(9):2161-3.PMID: 11522685 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin secretion in women who have polycystic ovary syndrome and carry the Gly972Arg variant of insulin receptor substrate-1 in response to a high-glycemic or low-glycemic carbohydrate load.

Sir-Petermann T, Angel B, Maliqueo M, Santos JL, Riesco MV, Toloza H, Pérez-Bravo F.

Nutrition. 2004 Oct;20(10):905-10.PMID: 15474880 [PubMed - indexed for MEDLINE]Related articles

Polymorphisms in the insulin receptor substrate-1 (IRS-1) gene and the insulin receptor substrate-2 (IRS-2) gene influence glucose homeostasis and body mass index in women with polycystic ovary syndrome and non-hyperandrogenic controls.

Villuendas G, Botella-Carretero JI, Roldán B, Sancho J, Escobar-Morreale HF, San Millán JL.

Hum Reprod. 2005 Nov;20(11):3184-91. Epub 2005 Jul 21.PMID: 16037106 [PubMed - indexed for MEDLINE]Related articlesFree article

New amino acid substitutions in the IRS-2 gene in Finnish and Chinese subjects with late-onset type 2 diabetes.

Wang H, Rissanen J, Miettinen R, Kärkkäinen P, Kekäläinen P, Kuusisto J, Mykkänen L, Karhapää P, Laakso M.

Diabetes. 2001 Aug;50(8):1949-51.PMID: 11473060 [PubMed - indexed for MEDLINE]Related articlesFree article

Clinical characterization of insulin secretion as the basis for genetic analyses.

Stumvoll M, Fritsche A, Häring HU.

Diabetes. 2002 Feb;51 Suppl 1:S122-9. Review.PMID: 11815470 [PubMed - indexed for MEDLINE]Related articlesFree article

Variations in insulin secretion in carriers of gene variants in IRS-1 and -2.

't Hart LM, Nijpels G, Dekker JM, Maassen JA, Heine RJ, van Haeften TW.

Diabetes. 2002 Mar;51(3):884-7.PMID: 11872698 [PubMed - indexed for MEDLINE]Related articlesFree article

Abnormal glucose tolerance and insulin resistance in polycystic ovary syndrome amongst the Taiwanese population- not correlated with insulin receptor substrate-1 Gly972Arg/Ala513Pro polymorphism.

Lin TC, Yen JM, Gong KB, Kuo TC, Ku DC, Liang SF, Wu MJ.

BMC Med Genet. 2006 Apr 7;7:36.PMID: 16603055 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic variability of the SUR1 promoter in relation to beta-cell function and Type II diabetes mellitus.

Hansen T, Ambye L, Grarup N, Hansen L, Echwald SM, Ferrer J, Pedersen O.

Diabetologia. 2001 Oct;44(10):1330-4.PMID: 11692183 [PubMed - indexed for MEDLINE]Related articles

The insulin receptor substrate-1 Gly972Arg polymorphism is not associated with Type 2 diabetes mellitus in two population-based studies.

van Dam RM, Hoebee B, Seidell JC, Schaap MM, Blaak EE, Feskens EJ.

Diabet Med. 2004 Jul;21(7):752-8.PMID: 15209769 [PubMed - indexed for MEDLINE]Related articles