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    Results: 1 to 20 of 139

    1.

    The Q allele variant (GLN121) of membrane glycoprotein PC-1 interacts with the insulin receptor and inhibits insulin signaling more effectively than the common K allele variant (LYS121).

    Costanzo BV, Trischitta V, Di Paola R, Spampinato D, Pizzuti A, Vigneri R, Frittitta L.

    Diabetes. 2001 Apr;50(4):831-6.PMID: 11289049 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit.

    Maddux BA, Goldfine ID.

    Diabetes. 2000 Jan;49(1):13-9.PMID: 10615944 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Overexpression of membrane glycoprotein PC-1 can influence insulin action at a post-receptor site.

    Kumakura S, Maddux BA, Sung CK.

    J Cell Biochem. 1998 Mar 1;68(3):366-77.PMID: 9518262 [PubMed - indexed for MEDLINE]Related articles

    4.

    Overexpression of membrane glycoprotein PC-1 in MDA-MB231 breast cancer cells is associated with inhibition of insulin receptor tyrosine kinase activity.

    Belfiore A, Costantino A, Frasca F, Pandini G, Mineo R, Vigneri P, Maddux B, Goldfine ID, Vigneri R.

    Mol Endocrinol. 1996 Nov;10(11):1318-26.PMID: 8923458 [PubMed - indexed for MEDLINE]Related articles

    5.

    Elevated plasma cell membrane glycoprotein levels and diminished insulin receptor autophosphorylation in obese, insulin-resistant rhesus monkeys.

    Pender C, Ortmeyer HK, Hansen BC, Goldfine ID, Youngren JF.

    Metabolism. 2002 Apr;51(4):465-70.PMID: 11912555 [PubMed - indexed for MEDLINE]Related articles

    6.

    Elevated PC-1 content in cultured skin fibroblasts correlates with decreased in vivo and in vitro insulin action in nondiabetic subjects: evidence that PC-1 may be an intrinsic factor in impaired insulin receptor signaling.

    Frittitta L, Spampinato D, Solini A, Nosadini R, Goldfine ID, Vigneri R, Trischitta V.

    Diabetes. 1998 Jul;47(7):1095-100.PMID: 9648833 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Plasma cell membrane glycoprotein 1 (PC-1): a marker of insulin resistance in obesity, uremia and diabetes mellitus.

    Stefanović V, Antić S.

    Clin Lab. 2004;50(5-6):271-8. Review.PMID: 15209435 [PubMed - indexed for MEDLINE]Related articles

    8.

    A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance.

    Pizzuti A, Frittitta L, Argiolas A, Baratta R, Goldfine ID, Bozzali M, Ercolino T, Scarlato G, Iacoviello L, Vigneri R, Tassi V, Trischitta V.

    Diabetes. 1999 Sep;48(9):1881-4.PMID: 10480624 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Decreased insulin receptor tyrosine kinase activity and plasma cell membrane glycoprotein-1 overexpression in skeletal muscle from obese women with gestational diabetes mellitus (GDM): evidence for increased serine/threonine phosphorylation in pregnancy and GDM.

    Shao J, Catalano PM, Yamashita H, Ruyter I, Smith S, Youngren J, Friedman JE.

    Diabetes. 2000 Apr;49(4):603-10.PMID: 10871198 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    The role of membrane glycoprotein plasma cell antigen 1/ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities.

    Goldfine ID, Maddux BA, Youngren JF, Reaven G, Accili D, Trischitta V, Vigneri R, Frittitta L.

    Endocr Rev. 2008 Feb;29(1):62-75. Epub 2008 Jan 16. Review. Erratum in: Endocr Rev. 2009 Feb;30(1):117. PMID: 18199690 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Alpha2-HSG, a specific inhibitor of insulin receptor autophosphorylation, interacts with the insulin receptor.

    Mathews ST, Chellam N, Srinivas PR, Cintron VJ, Leon MA, Goustin AS, Grunberger G.

    Mol Cell Endocrinol. 2000 Jun;164(1-2):87-98.PMID: 11026561 [PubMed - indexed for MEDLINE]Related articles

    12.

    High insulin levels do not influence PC-1 gene expression and protein content in human muscle tissue and hepatoma cells.

    Frittitta L, Sbraccia P, Costanzo BV, Tassi V, D'Adamo M, Spampinato D, Ercolino T, Purrello F, Tamburrano G, Vigneri R, Trischitta V.

    Diabetes Metab Res Rev. 2000 Jan-Feb;16(1):26-32.PMID: 10707036 [PubMed - indexed for MEDLINE]Related articles

    13.

    Inhibition of insulin receptor phosphorylation by PC-1 is not mediated by the hydrolysis of adenosine triphosphate or the generation of adenosine.

    Grupe A, Alleman J, Goldfine ID, Sadick M, Stewart TA.

    J Biol Chem. 1995 Sep 22;270(38):22085-8.PMID: 7673181 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Small molecule insulin receptor activators potentiate insulin action in insulin-resistant cells.

    Li M, Youngren JF, Manchem VP, Kozlowski M, Zhang BB, Maddux BA, Goldfine ID.

    Diabetes. 2001 Oct;50(10):2323-8.PMID: 11574415 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Essential role of insulin-like growth factor I receptor in insulin-induced fetal brown adipocyte differentiation.

    Mur C, Arribas M, Benito M, Valverde AM.

    Endocrinology. 2003 Feb;144(2):581-93.PMID: 12538620 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Role of PC-1 in the etiology of insulin resistance.

    Goldfine ID, Maddux BA, Youngren JF, Trischitta V, Frittitta L.

    Ann N Y Acad Sci. 1999 Nov 18;892:204-22. Review.PMID: 10842664 [PubMed - indexed for MEDLINE]Related articles

    17.

    Population-specific alleles: the polymorphism (K121Q) of the human glycoprotein PC-1 gene is strongly associated with race but not with insulin resistance in black and white children.

    Morrison JA, Gruppo R, Glueck CJ, Stroop D, Fontaine RN, Wang P, Smith KL.

    Metabolism. 2004 Apr;53(4):465-8.PMID: 15045693 [PubMed - indexed for MEDLINE]Related articles

    18.

    Membrane glycoprotein PC-1 and insulin resistance.

    Goldfine ID, Maddux BA, Youngren JF, Frittitta L, Trischitta V, Dohm GL.

    Mol Cell Biochem. 1998 May;182(1-2):177-84. Review.PMID: 9609127 [PubMed - indexed for MEDLINE]Related articles

    19.

    Expression of the putative inhibitor of the insulin receptor tyrosine kinase PC-1 in dermal fibroblasts from patients with syndromes of severe insulin resistance.

    Whitehead JP, Humphreys PJ, Dib K, Goding JW, O'Rahilly S.

    Clin Endocrinol (Oxf). 1997 Jul;47(1):65-70.PMID: 9302374 [PubMed - indexed for MEDLINE]Related articles

    20.

    A PC-1 amino acid variant (K121Q) is associated with faster progression of renal disease in patients with type 1 diabetes and albuminuria.

    De Cosmo S, Argiolas A, Miscio G, Thomas S, Piras GP, Trevisan R, Perin PC, Bacci S, Zucaro L, Margaglione M, Frittitta L, Pizzuti A, Tassi V, Viberti GC, Trischitta V.

    Diabetes. 2000 Mar;49(3):521-4.PMID: 10868979 [PubMed - indexed for MEDLINE]Related articlesFree article

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