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    Results: 1 to 20 of 226

    1.

    Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion?

    Lameloise N, Muzzin P, Prentki M, Assimacopoulos-Jeannet F.

    Diabetes. 2001 Apr;50(4):803-9.PMID: 11289045 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression.

    Joseph JW, Koshkin V, Saleh MC, Sivitz WI, Zhang CY, Lowell BB, Chan CB, Wheeler MB.

    J Biol Chem. 2004 Dec 3;279(49):51049-56. Epub 2004 Sep 23.PMID: 15448158 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action.

    Chan CB, De Leo D, Joseph JW, McQuaid TS, Ha XF, Xu F, Tsushima RG, Pennefather PS, Salapatek AM, Wheeler MB.

    Diabetes. 2001 Jun;50(6):1302-10.PMID: 11375330 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Role of ATP production and uncoupling protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferator-activated receptor-gamma inhibition.

    Patanè G, Anello M, Piro S, Vigneri R, Purrello F, Rabuazzo AM.

    Diabetes. 2002 Sep;51(9):2749-56.PMID: 12196468 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Role of uncoupling protein-2 up-regulation and triglyceride accumulation in impaired glucose-stimulated insulin secretion in a beta-cell lipotoxicity model overexpressing sterol regulatory element-binding protein-1c.

    Yamashita T, Eto K, Okazaki Y, Yamashita S, Yamauchi T, Sekine N, Nagai R, Noda M, Kadowaki T.

    Endocrinology. 2004 Aug;145(8):3566-77. Epub 2004 Apr 1.PMID: 15059954 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Induction of uncoupling protein 2 mRNA in beta-cells is stimulated by oxidation of fatty acids but not by nutrient oversupply.

    Li LX, Skorpen F, Egeberg K, Jørgensen IH, Grill V.

    Endocrinology. 2002 Apr;143(4):1371-7.PMID: 11897694 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Fatty acids rapidly induce the carnitine palmitoyltransferase I gene in the pancreatic beta-cell line INS-1.

    Assimacopoulos-Jeannet F, Thumelin S, Roche E, Esser V, McGarry JD, Prentki M.

    J Biol Chem. 1997 Jan 17;272(3):1659-64.PMID: 8999842 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Long-Term exposure of INS-1 cells to cis and trans fatty acids influences insulin release and fatty acid oxidation differentially.

    Alstrup KK, Brock B, Hermansen K.

    Metabolism. 2004 Sep;53(9):1158-65.PMID: 15334378 [PubMed - indexed for MEDLINE]Related articles

    9.

    Fatty acids do not activate UCP2 in pancreatic beta cells: comparison with UCP1.

    Galetti S, Sarre A, Perreten H, Produit-Zengaffinen N, Muzzin P, Assimacopoulos-Jeannet F.

    Pflugers Arch. 2009 Feb;457(4):931-40. Epub 2008 Jul 15.PMID: 18626658 [PubMed - indexed for MEDLINE]Related articles

    10.

    Taurine increases glucose sensitivity of UCP2-overexpressing beta-cells by ameliorating mitochondrial metabolism.

    Han J, Bae JH, Kim SY, Lee HY, Jang BC, Lee IK, Cho CH, Lim JG, Suh SI, Kwon TK, Park JW, Ryu SY, Ho WK, Earm YE, Song DK.

    Am J Physiol Endocrinol Metab. 2004 Nov;287(5):E1008-18. Epub 2004 Jul 20.PMID: 15265758 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Increasing uncoupling protein-2 in pancreatic beta cells does not alter glucose-induced insulin secretion but decreases production of reactive oxygen species.

    Produit-Zengaffinen N, Davis-Lameloise N, Perreten H, Bécard D, Gjinovci A, Keller PA, Wollheim CB, Herrera P, Muzzin P, Assimacopoulos-Jeannet F.

    Diabetologia. 2007 Jan;50(1):84-93. Epub 2006 Nov 28.PMID: 17131143 [PubMed - indexed for MEDLINE]Related articles

    12.

    Regulation of the uncoupling protein-2 gene in INS-1 beta-cells by oleic acid.

    Medvedev AV, Robidoux J, Bai X, Cao W, Floering LM, Daniel KW, Collins S.

    J Biol Chem. 2002 Nov 8;277(45):42639-44. Epub 2002 Aug 29.PMID: 12205102 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans.

    Zhou YP, Grill V.

    J Clin Endocrinol Metab. 1995 May;80(5):1584-90.PMID: 7745004 [PubMed - indexed for MEDLINE]Related articles

    14.

    Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet.

    Joseph JW, Koshkin V, Zhang CY, Wang J, Lowell BB, Chan CB, Wheeler MB.

    Diabetes. 2002 Nov;51(11):3211-9.PMID: 12401712 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Role and mechanism of rosiglitazone on the impairment of insulin secretion induced by free fatty acids on isolated rat islets.

    Tian JY, Li G, Gu YY, Zhang HL, Zhou WZ, Wang X, Zhu HD, Luo TH, Luo M.

    Chin Med J (Engl). 2006 Apr 5;119(7):574-80.PMID: 16620699 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Overexpression of short heterodimer partner recovers impaired glucose-stimulated insulin secretion of pancreatic beta-cells overexpressing UCP2.

    Suh YH, Kim SY, Lee HY, Jang BC, Bae JH, Sohn JN, Bae JH, Suh SI, Park JW, Lee KU, Song DK.

    J Endocrinol. 2004 Oct;183(1):133-44.PMID: 15525581 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Long-chain fatty acids inhibit acetyl-CoA carboxylase gene expression in the pancreatic beta-cell line INS-1.

    Brun T, Assimacopoulos-Jeannet F, Corkey BE, Prentki M.

    Diabetes. 1997 Mar;46(3):393-400.PMID: 9032094 [PubMed - indexed for MEDLINE]Related articles

    18.

    Glucosamine-induced alterations of mitochondrial function in pancreatic beta-cells: possible role of protein glycosylation.

    Anello M, Spampinato D, Piro S, Purrello F, Rabuazzo AM.

    Am J Physiol Endocrinol Metab. 2004 Oct;287(4):E602-8. Epub 2004 May 18.PMID: 15149952 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction.

    Krauss S, Zhang CY, Scorrano L, Dalgaard LT, St-Pierre J, Grey ST, Lowell BB.

    J Clin Invest. 2003 Dec;112(12):1831-42.PMID: 14679178 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Long-term exposure to glucose and lipids inhibits glucose-induced insulin secretion downstream of granule fusion with plasma membrane.

    Olofsson CS, Collins S, Bengtsson M, Eliasson L, Salehi A, Shimomura K, Tarasov A, Holm C, Ashcroft F, Rorsman P.

    Diabetes. 2007 Jul;56(7):1888-97. Epub 2007 Apr 24.PMID: 17456851 [PubMed - indexed for MEDLINE]Related articlesFree article

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