PubMed

The novel imidazoline compound BL11282 potentiates glucose-induced insulin secretion in pancreatic beta-cells in the absence of modulation of K(ATP) channel activity.

Efanov AM, Zaitsev SV, Mest HJ, Raap A, Appelskog IB, Larsson O, Berggren PO, Efendic S.

Diabetes. 2001 Apr;50(4):797-802.PMID: 11289044 [PubMed - indexed for MEDLINE]Related articlesFree article

Two generations of insulinotropic imidazoline compounds.

Efendic S, Efanov AM, Berggren PO, Zaitsev SV.

Diabetes. 2002 Dec;51 Suppl 3:S448-54. Review.PMID: 12475789 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulinotropic activity of the imidazoline derivative RX871024 in the diabetic GK rat.

Efanov AM, Appelskog IB, Abdel-Halim SM, Khan A, Bränström R, Larsson O, Ostenson CG, Mest HJ, Berggren PO, Efendic S, Zaitsev SV.

Am J Physiol Endocrinol Metab. 2002 Jan;282(1):E117-24.PMID: 11739091 [PubMed - indexed for MEDLINE]Related articlesFree article

Imidazoline NNC77-0074 stimulates insulin secretion and inhibits glucagon release by control of Ca(2+)-dependent exocytosis in pancreatic alpha- and beta-cells.

Høy M, Olsen HL, Andersen HS, Bokvist K, Buschard K, Hansen J, Jacobsen P, Petersen JS, Rorsman P, Gromada J.

Eur J Pharmacol. 2003 Apr 11;466(1-2):213-21.PMID: 12679159 [PubMed - indexed for MEDLINE]Related articles

The possible mechanisms by which phanoside stimulates insulin secretion from rat islets.

Hoa NK, Norberg A, Sillard R, Van Phan D, Thuan ND, Dzung DT, Jörnvall H, Ostenson CG.

J Endocrinol. 2007 Feb;192(2):389-94.PMID: 17283239 [PubMed - indexed for MEDLINE]Related articlesFree article

Arachidonic acid signaling is involved in the mechanism of imidazoline-induced KATP channel-independent stimulation of insulin secretion.

Sharoyko VV, Zaitseva II, Leibiger B, Efendić S, Berggren PO, Zaitsev SV.

Cell Mol Life Sci. 2007 Nov;64(22):2985-93.PMID: 17922229 [PubMed - indexed for MEDLINE]Related articles

cAMP enhances insulin secretion by an action on the ATP-sensitive K+ channel-independent pathway of glucose signaling in rat pancreatic islets.

Yajima H, Komatsu M, Schermerhorn T, Aizawa T, Kaneko T, Nagai M, Sharp GW, Hashizume K.

Diabetes. 1999 May;48(5):1006-12.PMID: 10331404 [PubMed - indexed for MEDLINE]Related articlesFree article

Clotrimazole and efaroxan stimulate insulin secretion by different mechanisms in rat pancreatic islets.

Chan SL, Pallett AL, Morgan NG.

Naunyn Schmiedebergs Arch Pharmacol. 1997 Dec;356(6):763-8.PMID: 9453462 [PubMed - indexed for MEDLINE]Related articles

Imidazoline compounds stimulate insulin release by inhibition of K(ATP) channels and interaction with the exocytotic machinery.

Zaitsev SV, Efanov AM, Efanova IB, Larsson O, Ostenson CG, Gold G, Berggren PO, Efendić S.

Diabetes. 1996 Nov;45(11):1610-8.PMID: 8866568 [PubMed - indexed for MEDLINE]Related articles

Augmentation of Ca2+-stimulated insulin release by glucose and long-chain fatty acids in rat pancreatic islets: free fatty acids mimic ATP-sensitive K+ channel-independent insulinotropic action of glucose.

Komatsu M, Yajima H, Yamada S, Kaneko T, Sato Y, Yamauchi K, Hashizume K, Aizawa T.

Diabetes. 1999 Aug;48(8):1543-9.PMID: 10426371 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action.

Chan CB, De Leo D, Joseph JW, McQuaid TS, Ha XF, Xu F, Tsushima RG, Pennefather PS, Salapatek AM, Wheeler MB.

Diabetes. 2001 Jun;50(6):1302-10.PMID: 11375330 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of a KATP channel-independent pathway involved in potentiation of insulin secretion by efaroxan.

Chan SL, Mourtada M, Morgan NG.

Diabetes. 2001 Feb;50(2):340-7.PMID: 11272145 [PubMed - indexed for MEDLINE]Related articlesFree article

ATP-sensitive potassium channels and efaroxan-induced insulin release in the electrofusion-derived BRIN-BD11 beta-cell line.

Chapman JC, McClenaghan NH, Cosgrove KE, Hashmi MN, Shepherd RM, Giesberts AN, White SJ, Ammälä C, Flatt PR, Dunne MJ.

Diabetes. 1999 Dec;48(12):2349-57.PMID: 10580423 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence for two different types of P2 receptors stimulating insulin secretion from pancreatic B cell.

Petit P, Hillaire-Buys D, Manteghetti M, Debrus S, Chapal J, Loubatières-Mariani MM.

Br J Pharmacol. 1998 Nov;125(6):1368-74.PMID: 9863669 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose dependence of imidazoline-induced insulin secretion: different characteristics of two ATP-Sensitive K+ channel-blocking compounds.

Bleck C, Wienbergen A, Rustenbeck I.

Diabetes. 2004 Dec;53 Suppl 3:S135-9.PMID: 15561901 [PubMed - indexed for MEDLINE]Related articlesFree article

The imidazoline NNC77-0020 affects glucose-dependent insulin, glucagon and somatostatin secretion in mouse pancreatic islets.

Høy M, Olsen HL, Bokvist K, Petersen JS, Gromada J.

Naunyn Schmiedebergs Arch Pharmacol. 2003 Oct;368(4):284-93. Epub 2003 Sep 6.PMID: 13680090 [PubMed - indexed for MEDLINE]Related articles

Glucose triggers protein kinase A-dependent insulin secretion in mouse pancreatic islets through activation of the K+ATP channel-dependent pathway.

Thams P, Anwar MR, Capito K.

Eur J Endocrinol. 2005 Apr;152(4):671-7.PMID: 15817925 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreatic islets from hypothalamic obese rats maintain K+ATP channel-dependent but not -independent pathways on glucose-induced insulin release process.

Grassiolli S, Bonfleur ML, Scomparin DX, de Freitas Mathias PC.

Endocrine. 2006 Oct;30(2):191-6.PMID: 17322578 [PubMed - indexed for MEDLINE]Related articles

BPDZ 154 activates adenosine 5'-triphosphate-sensitive potassium channels: in vitro studies using rodent insulin-secreting cells and islets isolated from patients with hyperinsulinism.

Cosgrove KE, Antoine MH, Lee AT, Barnes PD, de Tullio P, Clayton P, McCloy R, De Lonlay P, Nihoul-Fékété C, Robert JJ, Saudubray JM, Rahier J, Lindley KJ, Hussain K, Aynsley-Green A, Pirotte B, Lebrun P, Dunne MJ.

J Clin Endocrinol Metab. 2002 Nov;87(11):4860-8.PMID: 12414839 [PubMed - indexed for MEDLINE]Related articlesFree article

Electrophysiological and metabolic characterization of single beta-cells and islets from diabetic GK rats.

Hughes SJ, Faehling M, Thorneley CW, Proks P, Ashcroft FM, Smith PA.

Diabetes. 1998 Jan;47(1):73-81.PMID: 9421377 [PubMed - indexed for MEDLINE]Related articles