PubMed

Transgenic complementation of leptin-receptor deficiency. I. Rescue of the obesity/diabetes phenotype of LEPR-null mice expressing a LEPR-B transgene.

Kowalski TJ, Liu SM, Leibel RL, Chua SC Jr.

Diabetes. 2001 Feb;50(2):425-35.PMID: 11272157 [PubMed - indexed for MEDLINE]Related articlesFree article

Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes.

de Luca C, Kowalski TJ, Zhang Y, Elmquist JK, Lee C, Kilimann MW, Ludwig T, Liu SM, Chua SC Jr.

J Clin Invest. 2005 Dec;115(12):3484-93. Epub 2005 Nov 10.PMID: 16284652 [PubMed - indexed for MEDLINE]Related articlesFree article

Transgenic complementation of leptin receptor deficiency. II. Increased leptin receptor transgene dose effects on obesity/diabetes and fertility/lactation in lepr-db/db mice.

Chua SC Jr, Liu SM, Li Q, Sun A, DeNino WF, Heymsfield SB, Guo XE.

Am J Physiol Endocrinol Metab. 2004 Mar;286(3):E384-92. Epub 2003 Nov 4.PMID: 14600075 [PubMed - indexed for MEDLINE]Related articlesFree article

Neuronal deletion of Lepr elicits diabesity in mice without affecting cold tolerance or fertility.

McMinn JE, Liu SM, Liu H, Dragatsis I, Dietrich P, Ludwig T, Boozer CN, Chua SC Jr.

Am J Physiol Endocrinol Metab. 2005 Sep;289(3):E403-11. Epub 2005 May 3.PMID: 15870101 [PubMed - indexed for MEDLINE]Related articlesFree article

Transgenic neuronal expression of proopiomelanocortin attenuates hyperphagic response to fasting and reverses metabolic impairments in leptin-deficient obese mice.

Mizuno TM, Kelley KA, Pasinetti GM, Roberts JL, Mobbs CV.

Diabetes. 2003 Nov;52(11):2675-83.PMID: 14578285 [PubMed - indexed for MEDLINE]Related articlesFree article

STAT3 signalling is required for leptin regulation of energy balance but not reproduction.

Bates SH, Stearns WH, Dundon TA, Schubert M, Tso AW, Wang Y, Banks AS, Lavery HJ, Haq AK, Maratos-Flier E, Neel BG, Schwartz MW, Myers MG Jr.

Nature. 2003 Feb 20;421(6925):856-9.PMID: 12594516 [PubMed - indexed for MEDLINE]Related articles

Control of food intake via leptin receptors in the hypothalamus.

Meister B.

Vitam Horm. 2000;59:265-304. Review.PMID: 10714243 [PubMed - indexed for MEDLINE]Related articles

Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion.

van de Wall E, Leshan R, Xu AW, Balthasar N, Coppari R, Liu SM, Jo YH, MacKenzie RG, Allison DB, Dun NJ, Elmquist J, Lowell BB, Barsh GS, de Luca C, Myers MG Jr, Schwartz GJ, Chua SC Jr.

Endocrinology. 2008 Apr;149(4):1773-85. Epub 2007 Dec 27.PMID: 18162515 [PubMed - indexed for MEDLINE]Related articlesFree article

Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y neurons for normal energy homeostasis.

Gong L, Yao F, Hockman K, Heng HH, Morton GJ, Takeda K, Akira S, Low MJ, Rubinstein M, MacKenzie RG.

Endocrinology. 2008 Jul;149(7):3346-54. Epub 2008 Apr 10.PMID: 18403487 [PubMed - indexed for MEDLINE]Related articlesFree article

Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of Koletsky (fa(k)/fa(k)) rats.

Morton GJ, Niswender KD, Rhodes CJ, Myers MG Jr, Blevins JE, Baskin DG, Schwartz MW.

Endocrinology. 2003 May;144(5):2016-24.PMID: 12697710 [PubMed - indexed for MEDLINE]Related articlesFree article

Physiological and anatomical circuitry between Agouti-related protein and leptin signaling.

Wilson BD, Bagnol D, Kaelin CB, Ollmann MM, Gantz I, Watson SJ, Barsh GS.

Endocrinology. 1999 May;140(5):2387-97.PMID: 10218993 [PubMed - indexed for MEDLINE]Related articlesFree article

Neuropeptidergic characterization of the leptin receptor mutated obese Koletsky rat.

Keen Rhinehart E, Kalra SP, Kalra PS.

Regul Pept. 2004 Jun 15;119(1-2):3-10.PMID: 15093691 [PubMed - indexed for MEDLINE]Related articles

Leptin regulation of Agrp and Npy mRNA in the rat hypothalamus.

Korner J, Savontaus E, Chua SC Jr, Leibel RL, Wardlaw SL.

J Neuroendocrinol. 2001 Nov;13(11):959-66.PMID: 11737554 [PubMed - indexed for MEDLINE]Related articles

Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation.

Gao Q, Wolfgang MJ, Neschen S, Morino K, Horvath TL, Shulman GI, Fu XY.

Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4661-6. Epub 2004 Mar 22.PMID: 15070774 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin receptor-deficient MMTV-TGF-alpha/Lepr(db)Lepr(db) female mice do not develop oncogene-induced mammary tumors.

Cleary MP, Juneja SC, Phillips FC, Hu X, Grande JP, Maihle NJ.

Exp Biol Med (Maywood). 2004 Feb;229(2):182-93.PMID: 14734797 [PubMed - indexed for MEDLINE]Related articlesFree article

Contrasting obesity phenotypes uncovered by partial leptin receptor gene deletion in transgenic mice.

Reichart U, Renner-Müller I, Höflich A, Müller OJ, Franz WM, Wolf E, Müller M, Brem G, Aigner B.

Biochem Biophys Res Commun. 2000 Mar 16;269(2):502-7.PMID: 10708583 [PubMed - indexed for MEDLINE]Related articles

An allelic series for the leptin receptor gene generated by CRE and FLP recombinase.

McMinn JE, Liu SM, Dragatsis I, Dietrich P, Ludwig T, Eiden S, Chua SC Jr.

Mamm Genome. 2004 Sep;15(9):677-85.PMID: 15389315 [PubMed - indexed for MEDLINE]Related articles

Partial leptin receptor gene deletion in transgenic mice prevents expression of the membrane-bound isoforms except for Ob-Rc.

Reichart U, Kappler R, Scherthan H, Wolf E, Müller M, Brem G, Aigner B.

Biochem Biophys Res Commun. 2000 Mar 16;269(2):496-501.PMID: 10708582 [PubMed - indexed for MEDLINE]Related articles

Severe leptin resistance in brown fat-deficient uncoupling protein promoter-driven diphtheria toxin A mice despite suppression of hypothalamic neuropeptide Y and circulating corticosterone concentrations.

Mantzoros CS, Frederich RC, Qu D, Lowell BB, Maratos-Flier E, Flier JS.

Diabetes. 1998 Feb;47(2):230-8. Erratum in: Diabetes 1998 May;47(5):855. PMID: 9519718 [PubMed - indexed for MEDLINE]Related articles

Increased expression of hypothalamic leptin receptor and adiponectin accompany resistance to dietary-induced obesity and infertility in female C57BL/6J mice.

Tortoriello DV, McMinn JE, Chua SC.

Int J Obes (Lond). 2007 Mar;31(3):395-402. Epub 2006 Jul 25.PMID: 16865100 [PubMed - indexed for MEDLINE]Related articles