PubMed

Metabolic regulation by leucine of translation initiation through the mTOR-signaling pathway by pancreatic beta-cells.

Xu G, Kwon G, Cruz WS, Marshall CA, McDaniel ML.

Diabetes. 2001 Feb;50(2):353-60.PMID: 11272147 [PubMed - indexed for MEDLINE]Related articlesFree article

Branched-chain amino acids are essential in the regulation of PHAS-I and p70 S6 kinase by pancreatic beta-cells. A possible role in protein translation and mitogenic signaling.

Xu G, Kwon G, Marshall CA, Lin TA, Lawrence JC Jr, McDaniel ML.

J Biol Chem. 1998 Oct 23;273(43):28178-84.PMID: 9774438 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic and autocrine regulation of the mammalian target of rapamycin by pancreatic beta-cells.

McDaniel ML, Marshall CA, Pappan KL, Kwon G.

Diabetes. 2002 Oct;51(10):2877-85. Review.PMID: 12351422 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-like growth factor-1 (IGF-1) and leucine activate pig myogenic satellite cells through mammalian target of rapamycin (mTOR) pathway.

Han B, Tong J, Zhu MJ, Ma C, Du M.

Mol Reprod Dev. 2008 May;75(5):810-7.PMID: 18033679 [PubMed - indexed for MEDLINE]Related articles

Signaling elements involved in the metabolic regulation of mTOR by nutrients, incretins, and growth factors in islets.

Kwon G, Marshall CA, Pappan KL, Remedi MS, McDaniel ML.

Diabetes. 2004 Dec;53 Suppl 3:S225-32. Review.PMID: 15561916 [PubMed - indexed for MEDLINE]Related articlesFree article

Fibronectin stimulates non-small cell lung carcinoma cell growth through activation of Akt/mammalian target of rapamycin/S6 kinase and inactivation of LKB1/AMP-activated protein kinase signal pathways.

Han S, Khuri FR, Roman J.

Cancer Res. 2006 Jan 1;66(1):315-23.PMID: 16397245 [PubMed - indexed for MEDLINE]Related articlesFree article

Amino acids and insulin control autophagic proteolysis through different signaling pathways in relation to mTOR in isolated rat hepatocytes.

Kanazawa T, Taneike I, Akaishi R, Yoshizawa F, Furuya N, Fujimura S, Kadowaki M.

J Biol Chem. 2004 Feb 27;279(9):8452-9. Epub 2003 Nov 10.PMID: 14610086 [PubMed - indexed for MEDLINE]Related articlesFree article

Leucine-induced activation of translational initiation is partly regulated by the branched-chain alpha-keto acid dehydrogenase complex in C2C12 cells.

Nakai N, Shimomura Y, Tamura T, Tamura N, Hamada K, Kawano F, Ohira Y.

Biochem Biophys Res Commun. 2006 May 19;343(4):1244-50. Epub 2006 Mar 22.PMID: 16581023 [PubMed - indexed for MEDLINE]Related articles

Potential role of leucine metabolism in the leucine-signaling pathway involving mTOR.

Lynch CJ, Halle B, Fujii H, Vary TC, Wallin R, Damuni Z, Hutson SM.

Am J Physiol Endocrinol Metab. 2003 Oct;285(4):E854-63. Epub 2003 Jun 17.PMID: 12812918 [PubMed - indexed for MEDLINE]Related articlesFree article

Leucine stimulates mammalian target of rapamycin signaling in C2C12 myoblasts in part through inhibition of adenosine monophosphate-activated protein kinase.

Du M, Shen QW, Zhu MJ, Ford SP.

J Anim Sci. 2007 Apr;85(4):919-27. Epub 2006 Dec 18.PMID: 17178807 [PubMed - indexed for MEDLINE]Related articlesFree article

Endotoxin disrupts the leucine-signaling pathway involving phosphorylation of mTOR, 4E-BP1, and S6K1 in skeletal muscle.

Lang CH, Frost RA.

J Cell Physiol. 2005 Apr;203(1):144-55.PMID: 15389631 [PubMed - indexed for MEDLINE]Related articles

Cytoplasmic-nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapamycin-sensitive signaling and translation initiation.

Kim JE, Chen J.

Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14340-5.PMID: 11114166 [PubMed - indexed for MEDLINE]Related articlesFree article

Leucine stimulates HGF production by hepatic stellate cells through mTOR pathway.

Tomiya T, Nishikawa T, Inoue Y, Ohtomo N, Ikeda H, Tejima K, Watanabe N, Tanoue Y, Omata M, Fujiwara K.

Biochem Biophys Res Commun. 2007 Jun 22;358(1):176-80. Epub 2007 Apr 23.PMID: 17466941 [PubMed - indexed for MEDLINE]Related articles

Arginine and Leucine regulate p70 S6 kinase and 4E-BP1 in intestinal epithelial cells.

Ban H, Shigemitsu K, Yamatsuji T, Haisa M, Nakajo T, Takaoka M, Nobuhisa T, Gunduz M, Tanaka N, Naomoto Y.

Int J Mol Med. 2004 Apr;13(4):537-43.PMID: 15010853 [PubMed - indexed for MEDLINE]Related articles

Branched-chain amino acids activate key enzymes in protein synthesis after physical exercise.

Blomstrand E, Eliasson J, Karlsson HK, Köhnke R.

J Nutr. 2006 Jan;136(1 Suppl):269S-73S. Review.PMID: 16365096 [PubMed - indexed for MEDLINE]Related articlesFree article

Nutrient signalling in the regulation of human muscle protein synthesis.

Fujita S, Dreyer HC, Drummond MJ, Glynn EL, Cadenas JG, Yoshizawa F, Volpi E, Rasmussen BB.

J Physiol. 2007 Jul 15;582(Pt 2):813-23. Epub 2007 May 3.PMID: 17478528 [PubMed - indexed for MEDLINE]Related articlesFree article

Amino acid signaling through the mammalian target of rapamycin (mTOR) pathway: Role of glutamine and of cell shrinkage.

Fumarola C, La Monica S, Guidotti GG.

J Cell Physiol. 2005 Jul;204(1):155-65.PMID: 15605414 [PubMed - indexed for MEDLINE]Related articles

Leucine activates pancreatic translational machinery in rats and mice through mTOR independently of CCK and insulin.

Sans MD, Tashiro M, Vogel NL, Kimball SR, D'Alecy LG, Williams JA.

J Nutr. 2006 Jul;136(7):1792-9.PMID: 16772439 [PubMed - indexed for MEDLINE]Related articlesFree article

Tissue-specific effects of chronic dietary leucine and norleucine supplementation on protein synthesis in rats.

Lynch CJ, Hutson SM, Patson BJ, Vaval A, Vary TC.

Am J Physiol Endocrinol Metab. 2002 Oct;283(4):E824-35.PMID: 12217901 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability.

Beugnet A, Tee AR, Taylor PM, Proud CG.

Biochem J. 2003 Jun 1;372(Pt 2):555-66. Erratum in: Biochem J. 2003 Aug 1;373(Pt 3):999. PMID: 12611592 [PubMed - indexed for MEDLINE]Related articlesFree article