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    Results: 1 to 20 of 1060

    1.

    Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids.

    Briaud I, Harmon JS, Kelpe CL, Segu VB, Poitout V.

    Diabetes. 2001 Feb;50(2):315-21.PMID: 11272142 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Inhibition of insulin gene expression by long-term exposure of pancreatic beta cells to palmitate is dependent on the presence of a stimulatory glucose concentration.

    Jacqueminet S, Briaud I, Rouault C, Reach G, Poitout V.

    Metabolism. 2000 Apr;49(4):532-6.PMID: 10778881 [PubMed - indexed for MEDLINE]Related articles

    3.

    Inhibitory effects of fatty acids on glucose-regulated B-cell function: association with increased islet triglyceride stores and altered effect of fatty acid oxidation on glucose metabolism.

    Zhou YP, Ling ZC, Grill VE.

    Metabolism. 1996 Aug;45(8):981-6.PMID: 8769356 [PubMed - indexed for MEDLINE]Related articles

    4.

    Increasing triglyceride synthesis inhibits glucose-induced insulin secretion in isolated rat islets of langerhans: a study using adenoviral expression of diacylglycerol acyltransferase.

    Kelpe CL, Johnson LM, Poitout V.

    Endocrinology. 2002 Sep;143(9):3326-32.PMID: 12193544 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis.

    Kelpe CL, Moore PC, Parazzoli SD, Wicksteed B, Rhodes CJ, Poitout V.

    J Biol Chem. 2003 Aug 8;278(32):30015-21. Epub 2003 May 27.PMID: 12771145 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans.

    Zhou YP, Grill V.

    J Clin Endocrinol Metab. 1995 May;80(5):1584-90.PMID: 7745004 [PubMed - indexed for MEDLINE]Related articles

    7.

    Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression.

    Joseph JW, Koshkin V, Saleh MC, Sivitz WI, Zhang CY, Lowell BB, Chan CB, Wheeler MB.

    J Biol Chem. 2004 Dec 3;279(49):51049-56. Epub 2004 Sep 23.PMID: 15448158 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Palmitate potentiation of glucose-induced insulin release: a study using 2-bromopalmitate.

    Parker SM, Moore PC, Johnson LM, Poitout V.

    Metabolism. 2003 Oct;52(10):1367-71.PMID: 14564691 [PubMed - indexed for MEDLINE]Related articles

    9.

    Beta cell compensation for insulin resistance in Zucker fatty rats: increased lipolysis and fatty acid signalling.

    Nolan CJ, Leahy JL, Delghingaro-Augusto V, Moibi J, Soni K, Peyot ML, Fortier M, Guay C, Lamontagne J, Barbeau A, Przybytkowski E, Joly E, Masiello P, Wang S, Mitchell GA, Prentki M.

    Diabetologia. 2006 Sep;49(9):2120-30. Epub 2006 Jul 26.PMID: 16868750 [PubMed - indexed for MEDLINE]Related articles

    10.

    Stimulation of islet protein kinase C translocation by palmitate requires metabolism of the fatty acid.

    Alcázar O, Qiu-yue Z, Giné E, Tamarit-Rodriguez J.

    Diabetes. 1997 Jul;46(7):1153-8.PMID: 9200650 [PubMed - indexed for MEDLINE]Related articles

    11.

    Fatty acids rapidly induce the carnitine palmitoyltransferase I gene in the pancreatic beta-cell line INS-1.

    Assimacopoulos-Jeannet F, Thumelin S, Roche E, Esser V, McGarry JD, Prentki M.

    J Biol Chem. 1997 Jan 17;272(3):1659-64.PMID: 8999842 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Metformin restores insulin secretion altered by chronic exposure to free fatty acids or high glucose: a direct metformin effect on pancreatic beta-cells.

    Patanè G, Piro S, Rabuazzo AM, Anello M, Vigneri R, Purrello F.

    Diabetes. 2000 May;49(5):735-40.PMID: 10905481 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Glucose-induced preproinsulin gene expression is inhibited by the free fatty acid palmitate.

    Ritz-Laser B, Meda P, Constant I, Klages N, Charollais A, Morales A, Magnan C, Ktorza A, Philippe J.

    Endocrinology. 1999 Sep;140(9):4005-14.PMID: 10465270 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans.

    Hagman DK, Hays LB, Parazzoli SD, Poitout V.

    J Biol Chem. 2005 Sep 16;280(37):32413-8. Epub 2005 Jun 8.PMID: 15944145 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Long-term exposure of isolated rat islets of Langerhans to supraphysiologic glucose concentrations decreases insulin mRNA levels.

    Briaud I, Rouault C, Reach G, Poitout V.

    Metabolism. 1999 Mar;48(3):319-23.PMID: 10094107 [PubMed - indexed for MEDLINE]Related articles

    16.

    Porcine leptin inhibits lipogenesis in porcine adipocytes.

    Ramsay TG.

    J Anim Sci. 2003 Dec;81(12):3008-17.PMID: 14677856 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Octanoate inhibits triglyceride synthesis in 3T3-L1 and human adipocytes.

    Guo W, Lei T, Wang T, Corkey BE, Han J.

    J Nutr. 2003 Aug;133(8):2512-8.PMID: 12888629 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Increased lipogenic capacity of the islets of obese rats: a role in the pathogenesis of NIDDM.

    Lee Y, Hirose H, Zhou YT, Esser V, McGarry JD, Unger RH.

    Diabetes. 1997 Mar;46(3):408-13.PMID: 9032096 [PubMed - indexed for MEDLINE]Related articles

    19.

    Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells.

    Fontés G, Semache M, Hagman DK, Tremblay C, Shah R, Rhodes CJ, Rutter J, Poitout V.

    Diabetes. 2009 Sep;58(9):2048-58. Epub 2009 Jun 5.PMID: 19502418 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Acute effects of fatty acids on insulin secretion from rat and human islets of Langerhans.

    Gravena C, Mathias PC, Ashcroft SJ.

    J Endocrinol. 2002 Apr;173(1):73-80.PMID: 11927386 [PubMed - indexed for MEDLINE]Related articlesFree article

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