PubMed

Cellular mechanism of nutritionally induced insulin resistance in Psammomys obesus: overexpression of protein kinase Cepsilon in skeletal muscle precedes the onset of hyperinsulinemia and hyperglycemia.

Ikeda Y, Olsen GS, Ziv E, Hansen LL, Busch AK, Hansen BF, Shafrir E, Mosthaf-Seedorf L.

Diabetes. 2001 Mar;50(3):584-92.PMID: 11246878 [PubMed - indexed for MEDLINE]Related articlesFree article

Nutritionally induced insulin resistance and receptor defect leading to beta-cell failure in animal models.

Shafrir E, Ziv E, Mosthaf L.

Ann N Y Acad Sci. 1999 Nov 18;892:223-46. Review.PMID: 10842665 [PubMed - indexed for MEDLINE]Related articles

Physical exercise enhances protein kinase C delta activity and insulin receptor tyrosine phosphorylation in diabetes-prone psammomys obesus.

Heled Y, Shapiro Y, Shani Y, Moran DS, Langzam L, Braiman L, Sampson SR, Meyerovitch J.

Metabolism. 2003 Aug;52(8):1028-33.PMID: 12898468 [PubMed - indexed for MEDLINE]Related articles

Prevention of insulin resistance and beta-cell loss by abrogating PKCepsilon-induced serine phosphorylation of muscle IRS-1 in Psammomys obesus.

Mack E, Ziv E, Reuveni H, Kalman R, Niv MY, Jörns A, Lenzen S, Shafrir E.

Diabetes Metab Res Rev. 2008 Oct;24(7):577-84.PMID: 18613220 [PubMed - indexed for MEDLINE]Related articles

Albert Renold memorial lecture: molecular background of nutritionally induced insulin resistance leading to type 2 diabetes--from animal models to humans.

Shafrir E.

Int J Exp Diabetes Res. 2001;2(4):299-319.PMID: 11795838 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein tyrosine phosphatase 1B is impaired in skeletal muscle of diabetic Psammomys obesus.

Ikeda Y, Ziv E, Shafrir E, Mosthaf-Seedorf L.

Int J Exp Diabetes Res. 2002 Jul-Sep;3(3):205-12.PMID: 12458663 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-stimulated protein kinase C lambda/zeta activity is reduced in skeletal muscle of humans with obesity and type 2 diabetes: reversal with weight reduction.

Kim YB, Kotani K, Ciaraldi TP, Henry RR, Kahn BB.

Diabetes. 2003 Aug;52(8):1935-42.PMID: 12882908 [PubMed - indexed for MEDLINE]Related articlesFree article

Cellular mechanism of nutritionally induced insulin resistance: the desert rodent Psammomys obesus and other animals in which insulin resistance leads to detrimental outcome.

Shafrir E, Ziv E.

J Basic Clin Physiol Pharmacol. 1998;9(2-4):347-85.PMID: 10212843 [PubMed - indexed for MEDLINE]Related articles

Differential effects of tumor necrosis factor-alpha on protein kinase C isoforms alpha and delta mediate inhibition of insulin receptor signaling.

Rosenzweig T, Braiman L, Bak A, Alt A, Kuroki T, Sampson SR.

Diabetes. 2002 Jun;51(6):1921-30.PMID: 12031982 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic activation of protein kinase C in soleus muscles and other tissues of insulin-resistant type II diabetic Goto-Kakizaki (GK), obese/aged, and obese/Zucker rats. A mechanism for inhibiting glycogen synthesis.

Avignon A, Yamada K, Zhou X, Spencer B, Cardona O, Saba-Siddique S, Galloway L, Standaert ML, Farese RV.

Diabetes. 1996 Oct;45(10):1396-404.PMID: 8826977 [PubMed - indexed for MEDLINE]Related articles

Treatment of diabetes with vanadium salts: general overview and amelioration of nutritionally induced diabetes in the Psammomys obesus gerbil.

Shafrir E, Spielman S, Nachliel I, Khamaisi M, Bar-On H, Ziv E.

Diabetes Metab Res Rev. 2001 Jan-Feb;17(1):55-66. Review.PMID: 11241892 [PubMed - indexed for MEDLINE]Related articles

Defective stimulus-secretion coupling in islets of Psammomys obesus, an animal model for type 2 diabetes.

Nesher R, Warwar N, Khan A, Efendic S, Cerasi E, Kaiser N.

Diabetes. 2001 Feb;50(2):308-14.PMID: 11272141 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of insulin receptor gene expression and insulin signaling by fatty acid: interplay of PKC isoforms therein.

Dey D, Mukherjee M, Basu D, Datta M, Roy SS, Bandyopadhyay A, Bhattacharya S.

Cell Physiol Biochem. 2005;16(4-6):217-28.PMID: 16301821 [PubMed - indexed for MEDLINE]Related articles

Involvement of protein kinase C in human skeletal muscle insulin resistance and obesity.

Itani SI, Zhou Q, Pories WJ, MacDonald KG, Dohm GL.

Diabetes. 2000 Aug;49(8):1353-8.PMID: 10923637 [PubMed - indexed for MEDLINE]Related articlesFree article

Human glycated albumin affects glucose metabolism in L6 skeletal muscle cells by impairing insulin-induced insulin receptor substrate (IRS) signaling through a protein kinase C alpha-mediated mechanism.

Miele C, Riboulet A, Maitan MA, Oriente F, Romano C, Formisano P, Giudicelli J, Beguinot F, Van Obberghen E.

J Biol Chem. 2003 Nov 28;278(48):47376-87. Epub 2003 Sep 11.PMID: 12970360 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin induces specific interaction between insulin receptor and protein kinase C delta in primary cultured skeletal muscle.

Braiman L, Alt A, Kuroki T, Ohba M, Bak A, Tennenbaum T, Sampson SR.

Mol Endocrinol. 2001 Apr;15(4):565-74.PMID: 11266508 [PubMed - indexed for MEDLINE]Related articlesFree article

Alterations in the expression and cellular localization of protein kinase C isozymes epsilon and theta are associated with insulin resistance in skeletal muscle of the high-fat-fed rat.

Schmitz-Peiffer C, Browne CL, Oakes ND, Watkinson A, Chisholm DJ, Kraegen EW, Biden TJ.

Diabetes. 1997 Feb;46(2):169-78.PMID: 9000691 [PubMed - indexed for MEDLINE]Related articles

Protein kinase C isoforms alpha, delta and theta require insulin receptor substrate-1 to inhibit the tyrosine kinase activity of the insulin receptor in human kidney embryonic cells (HEK 293 cells).

Kellerer M, Mushack J, Seffer E, Mischak H, Ullrich A, Häring HU.

Diabetologia. 1998 Jul;41(7):833-8.PMID: 9686926 [PubMed - indexed for MEDLINE]Related articles

Cytosolic protein tyrosine phosphatase-epsilon is a negative regulator of insulin signaling in skeletal muscle.

Aga-Mizrachi S, Brutman-Barazani T, Jacob AI, Bak A, Elson A, Sampson SR.

Endocrinology. 2008 Feb;149(2):605-14. Epub 2007 Nov 15.PMID: 18006633 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of hyperglycemia on signal transduction in skeletal muscle from diabetic Goto-Kakizaki rats.

Steiler TL, Galuska D, Leng Y, Chibalin AV, Gilbert M, Zierath JR.

Endocrinology. 2003 Dec;144(12):5259-67. Epub 2003 Aug 21.PMID: 12960081 [PubMed - indexed for MEDLINE]Related articlesFree article