PubMed

The prohormone convertase enzyme 2 (PC2) is essential for processing pro-islet amyloid polypeptide at the NH2-terminal cleavage site.

Wang J, Xu J, Finnerty J, Furuta M, Steiner DF, Verchere CB.

Diabetes. 2001 Mar;50(3):534-9.PMID: 11246872 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide.

Marzban L, Trigo-Gonzalez G, Zhu X, Rhodes CJ, Halban PA, Steiner DF, Verchere CB.

Diabetes. 2004 Jan;53(1):141-8.PMID: 14693708 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of carboxypeptidase E in processing of pro-islet amyloid polypeptide in {beta}-cells.

Marzban L, Soukhatcheva G, Verchere CB.

Endocrinology. 2005 Apr;146(4):1808-17. Epub 2004 Dec 23.PMID: 15618358 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death.

Marzban L, Rhodes CJ, Steiner DF, Haataja L, Halban PA, Verchere CB.

Diabetes. 2006 Aug;55(8):2192-201.PMID: 16873681 [PubMed - indexed for MEDLINE]Related articlesFree article

Processing of synthetic pro-islet amyloid polypeptide (proIAPP) 'amylin' by recombinant prohormone convertase enzymes, PC2 and PC3, in vitro.

Higham CE, Hull RL, Lawrie L, Shennan KI, Morris JF, Birch NP, Docherty K, Clark A.

Eur J Biochem. 2000 Aug;267(16):4998-5004.PMID: 10931181 [PubMed - indexed for MEDLINE]Related articlesFree article

Processing of pro-islet amyloid polypeptide in the constitutive and regulated secretory pathways of beta cells.

Marzban L, Trigo-Gonzalez G, Verchere CB.

Mol Endocrinol. 2005 Aug;19(8):2154-63. Epub 2005 Mar 31.PMID: 15802374 [PubMed - indexed for MEDLINE]Related articlesFree article

Aberrant processing of human proislet amyloid polypeptide results in increased amyloid formation.

Paulsson JF, Westermark GT.

Diabetes. 2005 Jul;54(7):2117-25.PMID: 15983213 [PubMed - indexed for MEDLINE]Related articlesFree article

Processing of pro-islet amyloid polypeptide (proIAPP) by the prohormone convertase PC2.

Badman MK, Shennan KI, Jermany JL, Docherty K, Clark A.

FEBS Lett. 1996 Jan 15;378(3):227-31.PMID: 8557106 [PubMed - indexed for MEDLINE]Related articles

Incomplete processing of proinsulin to insulin accompanied by elevation of Des-31,32 proinsulin intermediates in islets of mice lacking active PC2.

Furuta M, Carroll R, Martin S, Swift HH, Ravazzola M, Orci L, Steiner DF.

J Biol Chem. 1998 Feb 6;273(6):3431-7.PMID: 9452465 [PubMed - indexed for MEDLINE]Related articlesFree article

Intracellular amyloid-like deposits contain unprocessed pro-islet amyloid polypeptide (proIAPP) in beta cells of transgenic mice overexpressing the gene for human IAPP and transplanted human islets.

Paulsson JF, Andersson A, Westermark P, Westermark GT.

Diabetologia. 2006 Jun;49(6):1237-46. Epub 2006 Mar 29.PMID: 16570161 [PubMed - indexed for MEDLINE]Related articles

Characterization of the heparin binding site in the N-terminus of human pro-islet amyloid polypeptide: implications for amyloid formation.

Abedini A, Tracz SM, Cho JH, Raleigh DP.

Biochemistry. 2006 Aug 1;45(30):9228-37.PMID: 16866369 [PubMed - indexed for MEDLINE]Related articles

Pro islet amyloid polypeptide (ProIAPP) immunoreactivity in the islets of Langerhans.

Westermark GT, Steiner DF, Gebre-Medhin S, Engström U, Westermark P.

Ups J Med Sci. 2000;105(2):97-106.PMID: 11095107 [PubMed - indexed for MEDLINE]Related articles

Differential processing of proglucagon by the subtilisin-like prohormone convertases PC2 and PC3 to generate either glucagon or glucagon-like peptide.

Rouillé Y, Martin S, Steiner DF.

J Biol Chem. 1995 Nov 3;270(44):26488-96.PMID: 7592866 [PubMed - indexed for MEDLINE]Related articlesFree article

Processing of prothyrotropin-releasing hormone (Pro-TRH) by bovine intermediate lobe secretory vesicle membrane PC1 and PC2 enzymes.

Friedman TC, Loh YP, Cawley NX, Birch NP, Huang SS, Jackson IM, Nillni EA.

Endocrinology. 1995 Oct;136(10):4462-72.PMID: 7664666 [PubMed - indexed for MEDLINE]Related articles

Comparative biosynthesis, covalent post-translational modifications and efficiency of prosegment cleavage of the prohormone convertases PC1 and PC2: glycosylation, sulphation and identification of the intracellular site of prosegment cleavage of PC1 and PC2.

Benjannet S, Rondeau N, Paquet L, Boudreault A, Lazure C, Chrétien M, Seidah NG.

Biochem J. 1993 Sep 15;294 ( Pt 3):735-43.PMID: 8397508 [PubMed - indexed for MEDLINE]Related articlesFree article

Levels of the conversion endoproteases PC1 (PC3) and PC2 distinguish between insulin-producing pancreatic islet beta cells and non-beta cells.

Neerman-Arbez M, Cirulli V, Halban PA.

Biochem J. 1994 May 15;300 ( Pt 1):57-61.PMID: 8198551 [PubMed - indexed for MEDLINE]Related articlesFree article

Biological processing of the cocaine and amphetamine-regulated transcript precursors by prohormone convertases, PC2 and PC1/3.

Dey A, Xhu X, Carroll R, Turck CW, Stein J, Steiner DF.

J Biol Chem. 2003 Apr 25;278(17):15007-14. Epub 2003 Feb 12.PMID: 12584191 [PubMed - indexed for MEDLINE]Related articlesFree article

Amyloidogenicity of recombinant human pro-islet amyloid polypeptide (ProIAPP).

Krampert M, Bernhagen J, Schmucker J, Horn A, Schmauder A, Brunner H, Voelter W, Kapurniotu A.

Chem Biol. 2000 Nov;7(11):855-71.PMID: 11094339 [PubMed - indexed for MEDLINE]Related articles

Amyloid formation by pro-islet amyloid polypeptide processing intermediates: examination of the role of protein heparan sulfate interactions and implications for islet amyloid formation in type 2 diabetes.

Meng F, Abedini A, Song B, Raleigh DP.

Biochemistry. 2007 Oct 30;46(43):12091-9. Epub 2007 Oct 9.PMID: 17924651 [PubMed - indexed for MEDLINE]Related articles

Immunocytochemical localization of prohormone convertases PC1/PC3 and PC2 in rat pancreatic islets.

Tanaka S, Kurabuchi S, Mochida H, Kato T, Takahashi S, Watanabe T, Nakayama K.

Arch Histol Cytol. 1996 Aug;59(3):261-71.PMID: 8874758 [PubMed - indexed for MEDLINE]Related articles