PubMed

Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function.

Maedler K, Spinas GA, Dyntar D, Moritz W, Kaiser N, Donath MY.

Diabetes. 2001 Jan;50(1):69-76.PMID: 11147797 [PubMed - indexed for MEDLINE]Related articlesFree article

Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function.

Maedler K, Oberholzer J, Bucher P, Spinas GA, Donath MY.

Diabetes. 2003 Mar;52(3):726-33.PMID: 12606514 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose and palmitic acid induce degeneration of myofibrils and modulate apoptosis in rat adult cardiomyocytes.

Dyntar D, Eppenberger-Eberhardt M, Maedler K, Pruschy M, Eppenberger HM, Spinas GA, Donath MY.

Diabetes. 2001 Sep;50(9):2105-13.PMID: 11522678 [PubMed - indexed for MEDLINE]Related articlesFree article

Arachidonic acid, palmitic acid and glucose are important for the modulation of clonal pancreatic beta-cell insulin secretion, growth and functional integrity.

Dixon G, Nolan J, McClenaghan NH, Flatt PR, Newsholme P.

Clin Sci (Lond). 2004 Feb;106(2):191-9.PMID: 14561212 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the beta-cell line INS-1.

Maestre I, Jordán J, Calvo S, Reig JA, Ceña V, Soria B, Prentki M, Roche E.

Endocrinology. 2003 Jan;144(1):335-45.PMID: 12488362 [PubMed - indexed for MEDLINE]Related articlesFree article

Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans.

Zhou YP, Grill V.

J Clin Endocrinol Metab. 1995 May;80(5):1584-90.PMID: 7745004 [PubMed - indexed for MEDLINE]Related articles

Adiponectin counteracts cytokine- and fatty acid-induced apoptosis in the pancreatic beta-cell line INS-1.

Rakatzi I, Mueller H, Ritzeler O, Tennagels N, Eckel J.

Diabetologia. 2004 Feb;47(2):249-58. Epub 2004 Jan 13.PMID: 14722646 [PubMed - indexed for MEDLINE]Related articles

Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells.

Eitel K, Staiger H, Rieger J, Mischak H, Brandhorst H, Brendel MD, Bretzel RG, Häring HU, Kellerer M.

Diabetes. 2003 Apr;52(4):991-7.PMID: 12663471 [PubMed - indexed for MEDLINE]Related articlesFree article

Augmentation of Ca2+-stimulated insulin release by glucose and long-chain fatty acids in rat pancreatic islets: free fatty acids mimic ATP-sensitive K+ channel-independent insulinotropic action of glucose.

Komatsu M, Yajima H, Yamada S, Kaneko T, Sato Y, Yamauchi K, Hashizume K, Aizawa T.

Diabetes. 1999 Aug;48(8):1543-9.PMID: 10426371 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-cell hypersensitivity to glucose following 24-h exposure of rat islets to fatty acids.

Hosokawa H, Corkey BE, Leahy JL.

Diabetologia. 1997 Apr;40(4):392-7.PMID: 9112015 [PubMed - indexed for MEDLINE]Related articles

Different role of saturated and unsaturated fatty acids in beta-cell apoptosis.

Eitel K, Staiger H, Brendel MD, Brandhorst D, Bretzel RG, Häring HU, Kellerer M.

Biochem Biophys Res Commun. 2002 Dec 20;299(5):853-6.PMID: 12470657 [PubMed - indexed for MEDLINE]Related articles

Unbound rather than total concentration and saturation rather than unsaturation determine the potency of fatty acids on insulin secretion.

Warnotte C, Nenquin M, Henquin JC.

Mol Cell Endocrinol. 1999 Jul 20;153(1-2):147-53.PMID: 10459862 [PubMed - indexed for MEDLINE]Related articles

Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.

Lupi R, Dotta F, Marselli L, Del Guerra S, Masini M, Santangelo C, Patané G, Boggi U, Piro S, Anello M, Bergamini E, Mosca F, Di Mario U, Del Prato S, Marchetti P.

Diabetes. 2002 May;51(5):1437-42.PMID: 11978640 [PubMed - indexed for MEDLINE]Related articlesFree article

Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes.

Shimabukuro M, Zhou YT, Levi M, Unger RH.

Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2498-502.PMID: 9482914 [PubMed - indexed for MEDLINE]Related articlesFree article

Palmitic acid increase levels of pancreatic duodenal homeobox-1 and p38/stress-activated protein kinase in islets from rats maintained on a low protein diet.

Arantes VC, Reis MA, Latorraca MQ, Ferreira F, Stoppiglia LF, Carneiro EM, Boschero AC.

Br J Nutr. 2006 Dec;96(6):1006-12.PMID: 17181874 [PubMed - indexed for MEDLINE]Related articles

Acute effects of fatty acids on insulin secretion from rat and human islets of Langerhans.

Gravena C, Mathias PC, Ashcroft SJ.

J Endocrinol. 2002 Apr;173(1):73-80.PMID: 11927386 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress.

Piro S, Anello M, Di Pietro C, Lizzio MN, Patanè G, Rabuazzo AM, Vigneri R, Purrello M, Purrello F.

Metabolism. 2002 Oct;51(10):1340-7.PMID: 12370856 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of the stimulation of insulin release by saturated fatty acids. A study of palmitate effects in mouse beta-cells.

Warnotte C, Gilon P, Nenquin M, Henquin JC.

Diabetes. 1994 May;43(5):703-11.PMID: 8168648 [PubMed - indexed for MEDLINE]Related articles

Long-chain fatty acids inhibit acetyl-CoA carboxylase gene expression in the pancreatic beta-cell line INS-1.

Brun T, Assimacopoulos-Jeannet F, Corkey BE, Prentki M.

Diabetes. 1997 Mar;46(3):393-400.PMID: 9032094 [PubMed - indexed for MEDLINE]Related articles

Differential protective effects of palmitoleic acid and cAMP on caspase activation and cell viability in pancreatic beta-cells exposed to palmitate.

Welters HJ, Diakogiannaki E, Mordue JM, Tadayyon M, Smith SA, Morgan NG.

Apoptosis. 2006 Jul;11(7):1231-8.PMID: 16703263 [PubMed - indexed for MEDLINE]Related articles