PubMed

Serine/threonine phosphorylation of IRS-1 triggers its degradation: possible regulation by tyrosine phosphorylation.

Pederson TM, Kramer DL, Rondinone CM.

Diabetes. 2001 Jan;50(1):24-31.PMID: 11147790 [PubMed - indexed for MEDLINE]Related articlesFree article

A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1.

Haruta T, Uno T, Kawahara J, Takano A, Egawa K, Sharma PM, Olefsky JM, Kobayashi M.

Mol Endocrinol. 2000 Jun;14(6):783-94.PMID: 10847581 [PubMed - indexed for MEDLINE]Related articlesFree article

Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin.

Takano A, Usui I, Haruta T, Kawahara J, Uno T, Iwata M, Kobayashi M.

Mol Cell Biol. 2001 Aug;21(15):5050-62.PMID: 11438661 [PubMed - indexed for MEDLINE]Related articlesFree article

Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling.

Tanti JF, Grémeaux T, van Obberghen E, Le Marchand-Brustel Y.

J Biol Chem. 1994 Feb 25;269(8):6051-7.PMID: 8119950 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of mTOR in the degradation of IRS-1: regulation of PP2A activity.

Hartley D, Cooper GM.

J Cell Biochem. 2002;85(2):304-14.PMID: 11948686 [PubMed - indexed for MEDLINE]Related articles

Vanadate and rapamycin synergistically enhance insulin-stimulated glucose uptake.

O'Connor JC, Freund GG.

Metabolism. 2003 Jun;52(6):666-74.PMID: 12800089 [PubMed - indexed for MEDLINE]Related articles

Proteasome inhibitors regulate tyrosine phosphorylation of IRS-1 and insulin signaling in adipocytes.

Rondinone CM, Kramer D.

Biochem Biophys Res Commun. 2002 Sep 6;296(5):1257-63.PMID: 12207909 [PubMed - indexed for MEDLINE]Related articles

Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1.

Zhande R, Mitchell JJ, Wu J, Sun XJ.

Mol Cell Biol. 2002 Feb;22(4):1016-26.PMID: 11809794 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation.

Greene MW, Sakaue H, Wang L, Alessi DR, Roth RA.

J Biol Chem. 2003 Mar 7;278(10):8199-211. Epub 2003 Jan 1.PMID: 12510059 [PubMed - indexed for MEDLINE]Related articlesFree article

Persistent activation of phosphatidylinositol 3-kinase causes insulin resistance due to accelerated insulin-induced insulin receptor substrate-1 degradation in 3T3-L1 adipocytes.

Egawa K, Nakashima N, Sharma PM, Maegawa H, Nagai Y, Kashiwagi A, Kikkawa R, Olefsky JM.

Endocrinology. 2000 Jun;141(6):1930-5.PMID: 10830273 [PubMed - indexed for MEDLINE]Related articlesFree article

Tumor necrosis factor alpha-induced phosphorylation of insulin receptor substrate-1 (IRS-1). Possible mechanism for suppression of insulin-stimulated tyrosine phosphorylation of IRS-1.

Kanety H, Feinstein R, Papa MZ, Hemi R, Karasik A.

J Biol Chem. 1995 Oct 6;270(40):23780-4.PMID: 7559552 [PubMed - indexed for MEDLINE]Related articlesFree article

IRS1 degradation and increased serine phosphorylation cannot predict the degree of metabolic insulin resistance induced by oxidative stress.

Potashnik R, Bloch-Damti A, Bashan N, Rudich A.

Diabetologia. 2003 May;46(5):639-48. Epub 2003 May 15.PMID: 12750770 [PubMed - indexed for MEDLINE]Related articles

Shp2 is required for protein kinase C-dependent phosphorylation of serine 307 in insulin receptor substrate-1.

Müssig K, Staiger H, Fiedler H, Moeschel K, Beck A, Kellerer M, Häring HU.

J Biol Chem. 2005 Sep 23;280(38):32693-9. Epub 2005 Jul 29.PMID: 16055440 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes.

Gual P, Gonzalez T, Grémeaux T, Barres R, Le Marchand-Brustel Y, Tanti JF.

J Biol Chem. 2003 Jul 18;278(29):26550-7. Epub 2003 May 1.PMID: 12730242 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulation of insulin receptor substrate-1 tyrosine phosphorylation by an Akt/phosphatidylinositol 3-kinase pathway.

Li J, DeFea K, Roth RA.

J Biol Chem. 1999 Apr 2;274(14):9351-6.PMID: 10092613 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanism of feedback regulation of insulin receptor substrate-1 phosphorylation in primary adipocytes.

Hers I, Tavaré JM.

Biochem J. 2005 Jun 1;388(Pt 2):713-20.PMID: 15713122 [PubMed - indexed for MEDLINE]Related articlesFree article

Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylation.

Carlson CJ, White MF, Rondinone CM.

Biochem Biophys Res Commun. 2004 Apr 2;316(2):533-9.PMID: 15020250 [PubMed - indexed for MEDLINE]Related articles

Muscarinic-receptor-mediated inhibition of insulin-like growth factor-1 receptor-stimulated phosphoinositide 3-kinase signalling in 1321N1 astrocytoma cells.

Batty IH, Fleming IN, Downes CP.

Biochem J. 2004 May 1;379(Pt 3):641-51.PMID: 14769130 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of insulin/insulin-like growth factor-1 signaling by proteasome-mediated degradation of insulin receptor substrate-2.

Rui L, Fisher TL, Thomas J, White MF.

J Biol Chem. 2001 Oct 26;276(43):40362-7. Epub 2001 Aug 23.PMID: 11546773 [PubMed - indexed for MEDLINE]Related articlesFree article

Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action.

Mothe I, Van Obberghen E.

J Biol Chem. 1996 May 10;271(19):11222-7.PMID: 8626671 [PubMed - indexed for MEDLINE]Related articlesFree article