PubMed

Virus-induced autoimmune diabetes: most beta-cells die through inflammatory cytokines and not perforin from autoreactive (anti-viral) cytotoxic T-lymphocytes.

Seewaldt S, Thomas HE, Ejrnaes M, Christen U, Wolfe T, Rodrigo E, Coon B, Michelsen B, Kay TW, von Herrath MG.

Diabetes. 2000 Nov;49(11):1801-9.PMID: 11078446 [PubMed - indexed for MEDLINE]Related articlesFree article

Development of insulitis without diabetes in transgenic mice lacking perforin-dependent cytotoxicity.

Kägi D, Odermatt B, Ohashi PS, Zinkernagel RM, Hengartner H.

J Exp Med. 1996 May 1;183(5):2143-52.PMID: 8642324 [PubMed - indexed for MEDLINE]Related articlesFree article

IL-1alpha, IL-1beta, and IFN-gamma mark beta cells for Fas-dependent destruction by diabetogenic CD4(+) T lymphocytes.

Amrani A, Verdaguer J, Thiessen S, Bou S, Santamaria P.

J Clin Invest. 2000 Feb;105(4):459-68.PMID: 10683375 [PubMed - indexed for MEDLINE]Related articlesFree article

Interferon-gamma is essential for destruction of beta cells and development of insulin-dependent diabetes mellitus.

von Herrath MG, Oldstone MB.

J Exp Med. 1997 Feb 3;185(3):531-9.PMID: 9053453 [PubMed - indexed for MEDLINE]Related articlesFree article

Pathological changes in the islet milieu precede infiltration of islets and destruction of beta-cells by autoreactive lymphocytes in a transgenic model of virus-induced IDDM.

von Herrath M, Holz A.

J Autoimmun. 1997 Jun;10(3):231-8.PMID: 9218748 [PubMed - indexed for MEDLINE]Related articles

In vivo treatment with a MHC class I-restricted blocking peptide can prevent virus-induced autoimmune diabetes.

von Herrath MG, Coon B, Lewicki H, Mazarguil H, Gairin JE, Oldstone MB.

J Immunol. 1998 Nov 1;161(9):5087-96.PMID: 9794447 [PubMed - indexed for MEDLINE]Related articlesFree article

Oral insulin treatment suppresses virus-induced antigen-specific destruction of beta cells and prevents autoimmune diabetes in transgenic mice.

von Herrath MG, Dyrberg T, Oldstone MB.

J Clin Invest. 1996 Sep 15;98(6):1324-31.PMID: 8823297 [PubMed - indexed for MEDLINE]Related articlesFree article

Perforin and Fas induced by IFNgamma and TNFalpha mediate beta cell death by OT-I CTL.

McKenzie MD, Dudek NL, Mariana L, Chong MM, Trapani JA, Kay TW, Thomas HE.

Int Immunol. 2006 Jun;18(6):837-46. Epub 2006 Mar 30.PMID: 16574667 [PubMed - indexed for MEDLINE]Related articlesFree article

Thymic tolerance to only one viral protein reduces lymphocytic choriomeningitis virus-induced immunopathology and increases survival in perforin-deficient mice.

von Herrath M, Coon B, Homann D, Wolfe T, Guidotti LG.

J Virol. 1999 Jul;73(7):5918-25.PMID: 10364344 [PubMed - indexed for MEDLINE]Related articlesFree article

Aplastic anemia rescued by exhaustion of cytokine-secreting CD8+ T cells in persistent infection with lymphocytic choriomeningitis virus.

Binder D, van den Broek MF, Kägi D, Bluethmann H, Fehr J, Hengartner H, Zinkernagel RM.

J Exp Med. 1998 Jun 1;187(11):1903-20.PMID: 9607930 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparing the relative role of perforin/granzyme versus Fas/Fas ligand cytotoxic pathways in CD8+ T cell-mediated insulin-dependent diabetes mellitus.

Kreuwel HT, Morgan DJ, Krahl T, Ko A, Sarvetnick N, Sherman LA.

J Immunol. 1999 Oct 15;163(8):4335-41.PMID: 10510373 [PubMed - indexed for MEDLINE]Related articlesFree article

Disruption of the STAT4 signaling pathway protects from autoimmune diabetes while retaining antiviral immune competence.

Holz A, Bot A, Coon B, Wolfe T, Grusby MJ, von Herrath MG.

J Immunol. 1999 Nov 15;163(10):5374-82.PMID: 10553062 [PubMed - indexed for MEDLINE]Related articlesFree article

Absence of TNFRp55 influences virus-induced autoimmunity despite efficient lymphocytic infiltration.

McKall-Faienza KJ, Kawai K, Kündig TM, Odermatt B, Bachmann MF, Zakarian A, Mak TW, Ohashi PS.

Int Immunol. 1998 Apr;10(4):405-12.PMID: 9620596 [PubMed - indexed for MEDLINE]Related articlesFree article

Bystander activation of cytotoxic T cells: studies on the mechanism and evaluation of in vivo significance in a transgenic mouse model.

Ehl S, Hombach J, Aichele P, Hengartner H, Zinkernagel RM.

J Exp Med. 1997 Apr 7;185(7):1241-51.PMID: 9104811 [PubMed - indexed for MEDLINE]Related articlesFree article

SOCS-1 protects from virally-induced CD8 T cell mediated type 1 diabetes.

Barral AM, Thomas HE, Ling EM, Darwiche R, Rodrigo E, Christen U, Ejrnaes M, Wolfe T, Kay TW, von Herrath MG.

J Autoimmun. 2006 Nov;27(3):166-73. Epub 2006 Oct 10.PMID: 17045460 [PubMed - indexed for MEDLINE]Related articles

IFN-gamma promotes Fas ligand- and perforin-mediated liver cell destruction by cytotoxic CD8 T cells.

Roth E, Pircher H.

J Immunol. 2004 Feb 1;172(3):1588-94.PMID: 14734739 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytotoxic T-cells from T-cell receptor transgenic NOD8.3 mice destroy beta-cells via the perforin and Fas pathways.

Dudek NL, Thomas HE, Mariana L, Sutherland RM, Allison J, Estella E, Angstetra E, Trapani JA, Santamaria P, Lew AM, Kay TW.

Diabetes. 2006 Sep;55(9):2412-8.PMID: 16936188 [PubMed - indexed for MEDLINE]Related articlesFree article

Autoimmune diabetes can be induced in transgenic major histocompatibility complex class II-deficient mice.

Laufer TM, von Herrath MG, Grusby MJ, Oldstone MB, Glimcher LH.

J Exp Med. 1993 Aug 1;178(2):589-96.PMID: 8101862 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet-specific expression of IL-10 promotes diabetes in nonobese diabetic mice independent of Fas, perforin, TNF receptor-1, and TNF receptor-2 molecules.

Balasa B, Van Gunst K, Jung N, Balakrishna D, Santamaria P, Hanafusa T, Itoh N, Sarvetnick N.

J Immunol. 2000 Sep 1;165(5):2841-9.PMID: 10946317 [PubMed - indexed for MEDLINE]Related articlesFree article

Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop diabetes due to a breakdown of T-lymphocyte unresponsiveness.

Harlan DM, Hengartner H, Huang ML, Kang YH, Abe R, Moreadith RW, Pircher H, Gray GS, Ohashi PS, Freeman GJ, et al.

Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3137-41.PMID: 7512724 [PubMed - indexed for MEDLINE]Related articlesFree article