PubMed

Interleukin-1beta-induced alteration in a beta-cell phenotype can reduce cellular sensitivity to conditions that cause necrosis but not to cytokine-induced apoptosis.

Ling Z, Van de Casteele M, Eizirik DL, Pipeleers DG.

Diabetes. 2000 Mar;49(3):340-5.PMID: 10868954 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of interferon regulatory factor-1 in cytokine-induced mRNA expression and cell death in murine pancreatic beta-cells.

Pavlovic D, Chen MC, Gysemans CA, Mathieu C, Eizirik DL.

Eur Cytokine Netw. 1999 Sep;10(3):403-12.PMID: 10477397 [PubMed - indexed for MEDLINE]Related articles

Distinction between interleukin-1-induced necrosis and apoptosis of islet cells.

Hoorens A, Stangé G, Pavlovic D, Pipeleers D.

Diabetes. 2001 Mar;50(3):551-7.PMID: 11246874 [PubMed - indexed for MEDLINE]Related articlesFree article

Intercellular differences in interleukin 1beta-induced suppression of insulin synthesis and stimulation of noninsulin protein synthesis by rat pancreatic beta-cells.

Ling Z, Chen MC, Smismans A, Pavlovic D, Schuit F, Eizirik DL, Pipeleers DG.

Endocrinology. 1998 Apr;139(4):1540-5.PMID: 9528932 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytokines induce apoptosis in beta-cells isolated from mice lacking the inducible isoform of nitric oxide synthase (iNOS-/-).

Liu D, Pavlovic D, Chen MC, Flodström M, Sandler S, Eizirik DL.

Diabetes. 2000 Jul;49(7):1116-22.PMID: 10909967 [PubMed - indexed for MEDLINE]Related articlesFree article

Double-stranded ribonucleic acid (RNA) induces beta-cell Fas messenger RNA expression and increases cytokine-induced beta-cell apoptosis.

Liu D, Darville M, Eizirik DL.

Endocrinology. 2001 Jun;142(6):2593-9.PMID: 11356709 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-like growth factors prevent cytokine-mediated cell death in isolated islets of Langerhans from pre-diabetic non-obese diabetic mice.

Hill DJ, Petrik J, Arany E, McDonald TJ, Delovitch TL.

J Endocrinol. 1999 Apr;161(1):153-65.PMID: 10194539 [PubMed - indexed for MEDLINE]Related articlesFree article

Suppressor of cytokine signaling 3 (SOCS-3) protects beta -cells against interleukin-1beta - and interferon-gamma -mediated toxicity.

Karlsen AE, Rønn SG, Lindberg K, Johannesen J, Galsgaard ED, Pociot F, Nielsen JH, Mandrup-Poulsen T, Nerup J, Billestrup N.

Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12191-6. Epub 2001 Oct 2.PMID: 11593036 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-cell maturation leads to in vitro sensitivity to cytotoxins.

Nielsen K, Karlsen AE, Deckert M, Madsen OD, Serup P, Mandrup-Poulsen T, Nerup J.

Diabetes. 1999 Dec;48(12):2324-32.PMID: 10580420 [PubMed - indexed for MEDLINE]Related articlesFree article

Dominant negative MyD88 proteins inhibit interleukin-1beta /interferon-gamma -mediated induction of nuclear factor kappa B-dependent nitrite production and apoptosis in beta cells.

Dupraz P, Cottet S, Hamburger F, Dolci W, Felley-Bosco E, Thorens B.

J Biol Chem. 2000 Dec 1;275(48):37672-8.PMID: 10967106 [PubMed - indexed for MEDLINE]Related articlesFree article

High glucose potentiates cytokine- and streptozotocin-induced apoptosis of rat islet cells: effect on apoptosis-related genes.

Mellado-Gil JM, Aguilar-Diosdado M.

J Endocrinol. 2004 Oct;183(1):155-62.PMID: 15525583 [PubMed - indexed for MEDLINE]Related articlesFree article

Complete protection against interleukin-1beta-induced functional suppression and cytokine-mediated cytotoxicity in rat pancreatic islets in vitro using an interleukin-1 cytokine trap.

Rydgren T, Bengtsson D, Sandler S.

Diabetes. 2006 May;55(5):1407-12.PMID: 16644698 [PubMed - indexed for MEDLINE]Related articlesFree article

Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress.

Kharroubi I, Ladrière L, Cardozo AK, Dogusan Z, Cnop M, Eizirik DL.

Endocrinology. 2004 Nov;145(11):5087-96. Epub 2004 Aug 5.PMID: 15297438 [PubMed - indexed for MEDLINE]Related articlesFree article

cFLIP protein prevents tumor necrosis factor-alpha-mediated induction of caspase-8-dependent apoptosis in insulin-secreting betaTc-Tet cells.

Cottet S, Dupraz P, Hamburger F, Dolci W, Jaquet M, Thorens B.

Diabetes. 2002 Jun;51(6):1805-14.PMID: 12031968 [PubMed - indexed for MEDLINE]Related articlesFree article

Ciliary neurotrophic factor potentiates the beta-cell inhibitory effect of IL-1beta in rat pancreatic islets associated with increased nitric oxide synthesis and increased expression of inducible nitric oxide synthase.

Wadt KA, Larsen CM, Andersen HU, Nielsen K, Karlsen AE, Mandrup-Poulsen T.

Diabetes. 1998 Oct;47(10):1602-8.PMID: 9753298 [PubMed - indexed for MEDLINE]Related articlesFree article

STAT5 activation by human GH protects insulin-producing cells against interleukin-1beta, interferon-gamma and tumour necrosis factor-alpha-induced apoptosis independent of nitric oxide production.

Jensen J, Galsgaard ED, Karlsen AE, Lee YC, Nielsen JH.

J Endocrinol. 2005 Oct;187(1):25-36.PMID: 16214938 [PubMed - indexed for MEDLINE]Related articlesFree article

Melatonin protects against streptozotocin, but not interleukin-1beta-induced damage of rodent pancreatic beta-cells.

Andersson AK, Sandler S.

J Pineal Res. 2001 Apr;30(3):157-65.PMID: 11316326 [PubMed - indexed for MEDLINE]Related articles

Variations in IB1/JIP1 expression regulate susceptibility of beta-cells to cytokine-induced apoptosis irrespective of C-Jun NH2-terminal kinase signaling.

Ling Z, Van de Casteele M, Dong J, Heimberg H, Haefliger JA, Waeber G, Schuit F, Pipeleers D.

Diabetes. 2003 Oct;52(10):2497-502.PMID: 14514632 [PubMed - indexed for MEDLINE]Related articlesFree article

Double-stranded RNA cooperates with interferon-gamma and IL-1 beta to induce both chemokine expression and nuclear factor-kappa B-dependent apoptosis in pancreatic beta-cells: potential mechanisms for viral-induced insulitis and beta-cell death in type 1 diabetes mellitus.

Liu D, Cardozo AK, Darville MI, Eizirik DL.

Endocrinology. 2002 Apr;143(4):1225-34.PMID: 11897677 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibitory effects of streptozotocin, tumor necrosis factor-alpha, and interleukin-1beta on glucokinase activity in pancreatic islets and gene expression of GLUT2 and glucokinase.

Park C, Kim JR, Shim JK, Kang BS, Park YG, Nam KS, Lee YC, Kim CH.

Arch Biochem Biophys. 1999 Feb 15;362(2):217-24.PMID: 9989930 [PubMed - indexed for MEDLINE]Related articles