PubMed

Recombinant human relaxin in the treatment of scleroderma. A randomized, double-blind, placebo-controlled trial.

Seibold JR, Korn JH, Simms R, Clements PJ, Moreland LW, Mayes MD, Furst DE, Rothfield N, Steen V, Weisman M, Collier D, Wigley FM, Merkel PA, Csuka ME, Hsu V, Rocco S, Erikson M, Hannigan J, Harkonen WS, Sanders ME.

Ann Intern Med. 2000 Jun 6;132(11):871-9.PMID: 10836913 [PubMed - indexed for MEDLINE]Related articlesFree article

Recombinant human relaxin in the treatment of systemic sclerosis with diffuse cutaneous involvement: a randomized, double-blind, placebo-controlled trial.

Khanna D, Clements PJ, Furst DE, Korn JH, Ellman M, Rothfield N, Wigley FM, Moreland LW, Silver R, Kim YH, Steen VD, Firestein GS, Kavanaugh AF, Weisman M, Mayes MD, Collier D, Csuka ME, Simms R, Merkel PA, Medsger TA Jr, Sanders ME, Maranian P, Seibold JR; Relaxin Investigators and the Scleroderma Clinical Trials Consortium.

Arthritis Rheum. 2009 Apr;60(4):1102-11.PMID: 19333948 [PubMed - indexed for MEDLINE]Related articles

Safety and pharmacokinetics of recombinant human relaxin in systemic sclerosis.

Seibold JR, Clements PJ, Furst DE, Mayes MD, McCloskey DA, Moreland LW, White B, Wigley FM, Rocco S, Erikson M, Hannigan JF, Sanders ME, Amento EP.

J Rheumatol. 1998 Feb;25(2):302-7.PMID: 9489823 [PubMed - indexed for MEDLINE]Related articles

A randomized, controlled trial of methotrexate versus placebo in early diffuse scleroderma.

Pope JE, Bellamy N, Seibold JR, Baron M, Ellman M, Carette S, Smith CD, Chalmers IM, Hong P, O'Hanlon D, Kaminska E, Markland J, Sibley J, Catoggio L, Furst DE.

Arthritis Rheum. 2001 Jun;44(6):1351-8.PMID: 11407694 [PubMed - indexed for MEDLINE]Related articlesFree article

Efficacy and safety of mixed amphetamine salts extended release (Adderall XR) in the management of attention-deficit/hyperactivity disorder in adolescent patients: a 4-week, randomized, double-blind, placebo-controlled, parallel-group study.

Spencer TJ, Wilens TE, Biederman J, Weisler RH, Read SC, Pratt R.

Clin Ther. 2006 Feb;28(2):266-79.PMID: 16678648 [PubMed - indexed for MEDLINE]Related articles

Responsiveness of the SF-36 and the Health Assessment Questionnaire Disability Index in a systemic sclerosis clinical trial.

Khanna D, Furst DE, Clements PJ, Park GS, Hays RD, Yoon J, Korn JH, Merkel PA, Rothfield N, Wigley FM, Moreland LW, Silver R, Steen VD, Weisman M, Mayes MD, Collier DH, Medsger TA Jr, Seibold JR; Relaxin Study Group; Scleroderma Clinical Trials Consortium.

J Rheumatol. 2005 May;32(5):832-40.PMID: 15868618 [PubMed - indexed for MEDLINE]Related articles

Oral iloprost treatment in patients with Raynaud's phenomenon secondary to systemic sclerosis: a multicenter, placebo-controlled, double-blind study.

Wigley FM, Korn JH, Csuka ME, Medsger TA Jr, Rothfield NF, Ellman M, Martin R, Collier DH, Weinstein A, Furst DE, Jimenez SA, Mayes MD, Merkel PA, Gruber B, Kaufman L, Varga J, Bell P, Kern J, Marrott P, White B, Simms RW, Phillips AC, Seibold JR.

Arthritis Rheum. 1998 Apr;41(4):670-7.PMID: 9550476 [PubMed - indexed for MEDLINE]Related articlesFree article

A randomized, blinded, parallel group, placebo controlled pilot study evaluating the effect of PVAC treatment in patients with diffuse systemic sclerosis.

Genovese MC, Chakravarty EF, Boyle DL, Tutuncu Z, Thorburn CM, Halilhodzic M, Kroll S, Baughman J, Stewart S, Kavanaugh A.

J Rheumatol. 2005 Dec;32(12):2345-50.PMID: 16331761 [PubMed - indexed for MEDLINE]Related articles

Efficacy and tolerability of fluticasone propionate/salmeterol administered twice daily via hydrofluoroalkane 134a metered-dose inhaler in adolescent and adult patients with persistent asthma: a randomized, double-blind, placebo-controlled, 12-week study.

Nathan RA, Rooklin A, Schoaf L, Scott C, Ellsworth A, House K, Dorinsky P.

Clin Ther. 2006 Jan;28(1):73-85.PMID: 16490581 [PubMed - indexed for MEDLINE]Related articles

Relaxin for the treatment of patients with acute heart failure (Pre-RELAX-AHF): a multicentre, randomised, placebo-controlled, parallel-group, dose-finding phase IIb study.

Teerlink JR, Metra M, Felker GM, Ponikowski P, Voors AA, Weatherley BD, Marmor A, Katz A, Grzybowski J, Unemori E, Teichman SL, Cotter G.

Lancet. 2009 Apr 25;373(9673):1429-39. Epub 2009 Mar 28.PMID: 19329178 [PubMed - indexed for MEDLINE]Related articles

Interferon-alpha does not improve outcome at one year in patients with diffuse cutaneous scleroderma: results of a randomized, double-blind, placebo-controlled trial.

Black CM, Silman AJ, Herrick AI, Denton CP, Wilson H, Newman J, Pompon L, Shi-Wen X.

Arthritis Rheum. 1999 Feb;42(2):299-305.PMID: 10025924 [PubMed - indexed for MEDLINE]Related articlesFree article

Course of the modified Rodnan skin thickness score in systemic sclerosis clinical trials: analysis of three large multicenter, double-blind, randomized controlled trials.

Amjadi S, Maranian P, Furst DE, Clements PJ, Wong WK, Postlethwaite AE, Khanna PP, Khanna D; Investigators of the D-Penicillamine, Human Recombinant Relaxin, and Oral Bovine Type I Collagen Clinical Trials.

Arthritis Rheum. 2009 Aug;60(8):2490-8.PMID: 19644851 [PubMed - indexed for MEDLINE]Related articlesFree article

A multicenter, prospective, randomized, double-blind, placebo-controlled trial of corticosteroids and intravenous cyclophosphamide followed by oral azathioprine for the treatment of pulmonary fibrosis in scleroderma.

Hoyles RK, Ellis RW, Wellsbury J, Lees B, Newlands P, Goh NS, Roberts C, Desai S, Herrick AL, McHugh NJ, Foley NM, Pearson SB, Emery P, Veale DJ, Denton CP, Wells AU, Black CM, du Bois RM.

Arthritis Rheum. 2006 Dec;54(12):3962-70.PMID: 17133610 [PubMed - indexed for MEDLINE]Related articlesFree article

Treprostinil, a prostacyclin analogue, in pulmonary arterial hypertension associated with connective tissue disease.

Oudiz RJ, Schilz RJ, Barst RJ, Galié N, Rich S, Rubin LJ, Simonneau G; Treprostinil Study Group.

Chest. 2004 Aug;126(2):420-7.PMID: 15302727 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparison of aminobenzoate potassium and placebo in the treatment of scleroderma.

Clegg DO, Reading JC, Mayes MD, Seibold JR, Harris C, Wigley FM, Ward JR, Pisko EJ, Weisman MH, Lee P, et al.

J Rheumatol. 1994 Jan;21(1):105-10.PMID: 8151563 [PubMed - indexed for MEDLINE]Related articles

Transdermal buprenorphine in the treatment of chronic pain: results of a phase III, multicenter, randomized, double-blind, placebo-controlled study.

Sorge J, Sittl R.

Clin Ther. 2004 Nov;26(11):1808-20.PMID: 15639693 [PubMed - indexed for MEDLINE]Related articles

Recombinant variant of ciliary neurotrophic factor for weight loss in obese adults: a randomized, dose-ranging study.

Ettinger MP, Littlejohn TW, Schwartz SL, Weiss SR, McIlwain HH, Heymsfield SB, Bray GA, Roberts WG, Heyman ER, Stambler N, Heshka S, Vicary C, Guler HP.

JAMA. 2003 Apr 9;289(14):1826-32.PMID: 12684362 [PubMed - indexed for MEDLINE]Related articlesFree article

Oral iloprost in Raynaud's phenomenon secondary to systemic sclerosis: a multicentre, placebo-controlled, dose-comparison study.

Black CM, Halkier-Sørensen L, Belch JJ, Ullman S, Madhok R, Smit AJ, Banga JD, Watson HR.

Br J Rheumatol. 1998 Sep;37(9):952-60.PMID: 9783759 [PubMed - indexed for MEDLINE]Related articlesFree article

Efficacy and tolerability of exenatide monotherapy over 24 weeks in antidiabetic drug-naive patients with type 2 diabetes: a randomized, double-blind, placebo-controlled, parallel-group study.

Moretto TJ, Milton DR, Ridge TD, Macconell LA, Okerson T, Wolka AM, Brodows RG.

Clin Ther. 2008 Aug;30(8):1448-60. Erratum in: Clin Ther. 2008 Oct;30(10):1937. PMID: 18803987 [PubMed - indexed for MEDLINE]Related articles

Efficacy, tolerability, and effect on asthma-related quality of life of formoterol bid via multidose dry powder inhaler and albuterol QID via metered dose inhaler in patients with persistent asthma: a multicenter, randomized, double-blind, double-dummy, placebo-controlled, parallel-group study.

Busse W, Levine B, Andriano K, Lavecchia C, Yegen U.

Clin Ther. 2004 Oct;26(10):1587-98.PMID: 15598475 [PubMed - indexed for MEDLINE]Related articles