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    Results: 1 to 20 of 141

    1.

    Beta-cell maturation leads to in vitro sensitivity to cytotoxins.

    Nielsen K, Karlsen AE, Deckert M, Madsen OD, Serup P, Mandrup-Poulsen T, Nerup J.

    Diabetes. 1999 Dec;48(12):2324-32.PMID: 10580420 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Gene expression profiles during beta cell maturation and after IL-1beta exposure reveal important roles of Pdx-1 and Nkx6.1 for IL-1beta sensitivity.

    Nielsen K, Kruhøffer M, Orntoft T, Sparre T, Wang H, Wollheim C, Jørgensen MC, Nerup J, Karlsen AE.

    Diabetologia. 2004 Dec;47(12):2185-99. Epub 2004 Dec 17.PMID: 15605246 [PubMed - indexed for MEDLINE]Related articles

    3.

    Protein expression changes in a cell system of beta-cell maturation reflect an acquired sensitivity to IL-1beta.

    Nielsen K, Sparre T, Larsen MR, Nielsen M, Fey SJ, Mose Larsen P, Roepstorff P, Nerup J, Karlsen AE.

    Diabetologia. 2004 Jan;47(1):62-74. Epub 2003 Dec 3.PMID: 14652719 [PubMed - indexed for MEDLINE]Related articles

    4.

    Interleukin-1beta-induced alteration in a beta-cell phenotype can reduce cellular sensitivity to conditions that cause necrosis but not to cytokine-induced apoptosis.

    Ling Z, Van de Casteele M, Eizirik DL, Pipeleers DG.

    Diabetes. 2000 Mar;49(3):340-5.PMID: 10868954 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta-cells.

    Ammendrup A, Maillard A, Nielsen K, Aabenhus Andersen N, Serup P, Dragsbaek Madsen O, Mandrup-Poulsen T, Bonny C.

    Diabetes. 2000 Sep;49(9):1468-76.PMID: 10969830 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Suppressor of cytokine signaling 3 (SOCS-3) protects beta -cells against interleukin-1beta - and interferon-gamma -mediated toxicity.

    Karlsen AE, Rønn SG, Lindberg K, Johannesen J, Galsgaard ED, Pociot F, Nielsen JH, Mandrup-Poulsen T, Nerup J, Billestrup N.

    Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12191-6. Epub 2001 Oct 2.PMID: 11593036 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Suppressive effects of a selective inducible nitric oxide synthase (iNOS) inhibitor on pancreatic beta-cell dysfunction.

    Kato Y, Miura Y, Yamamoto N, Ozaki N, Oiso Y.

    Diabetologia. 2003 Sep;46(9):1228-33. Epub 2003 Jul 24.PMID: 12898012 [PubMed - indexed for MEDLINE]Related articles

    8.

    Protection of insulin-producing RINm5F cells against cytokine-mediated toxicity through overexpression of antioxidant enzymes.

    Lortz S, Tiedge M, Nachtwey T, Karlsen AE, Nerup J, Lenzen S.

    Diabetes. 2000 Jul;49(7):1123-30.PMID: 10909968 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Osteopontin protects the islets and beta-cells from interleukin-1 beta-mediated cytotoxicity through negative feedback regulation of nitric oxide.

    Arafat HA, Katakam AK, Chipitsyna G, Gong Q, Vancha AR, Gabbeta J, Dafoe DC.

    Endocrinology. 2007 Feb;148(2):575-84. Epub 2006 Nov 16.PMID: 17110428 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Double-stranded ribonucleic acid (RNA) induces beta-cell Fas messenger RNA expression and increases cytokine-induced beta-cell apoptosis.

    Liu D, Darville M, Eizirik DL.

    Endocrinology. 2001 Jun;142(6):2593-9.PMID: 11356709 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Cytokines induce apoptosis in beta-cells isolated from mice lacking the inducible isoform of nitric oxide synthase (iNOS-/-).

    Liu D, Pavlovic D, Chen MC, Flodström M, Sandler S, Eizirik DL.

    Diabetes. 2000 Jul;49(7):1116-22.PMID: 10909967 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Redox-mediated enrichment of self-renewing adult human pancreatic cells that possess endocrine differentiation potential.

    Linning KD, Tai MH, Madhukar BV, Chang CC, Reed DN Jr, Ferber S, Trosko JE, Olson LK.

    Pancreas. 2004 Oct;29(3):e64-76.PMID: 15367896 [PubMed - indexed for MEDLINE]Related articles

    13.

    Identification of novel cytokine-induced genes in pancreatic beta-cells by high-density oligonucleotide arrays.

    Cardozo AK, Kruhøffer M, Leeman R, Orntoft T, Eizirik DL.

    Diabetes. 2001 May;50(5):909-20.PMID: 11334433 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Tissue inhibitor of metalloproteinase-1 prevents cytokine-mediated dysfunction and cytotoxicity in pancreatic islets and beta-cells.

    Han X, Sun Y, Scott S, Bleich D.

    Diabetes. 2001 May;50(5):1047-55.PMID: 11334407 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1 beta-exposed human and rat islet cells.

    Chen MC, Proost P, Gysemans C, Mathieu C, Eizirik DL.

    Diabetologia. 2001 Mar;44(3):325-32.PMID: 11317664 [PubMed - indexed for MEDLINE]Related articles

    16.

    Discovery of gene networks regulating cytokine-induced dysfunction and apoptosis in insulin-producing INS-1 cells.

    Kutlu B, Cardozo AK, Darville MI, Kruhøffer M, Magnusson N, Ørntoft T, Eizirik DL.

    Diabetes. 2003 Nov;52(11):2701-19.PMID: 14578289 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    PDX-1 induces differentiation of intestinal epithelioid IEC-6 into insulin-producing cells.

    Yoshida S, Kajimoto Y, Yasuda T, Watada H, Fujitani Y, Kosaka H, Gotow T, Miyatsuka T, Umayahara Y, Yamasaki Y, Hori M.

    Diabetes. 2002 Aug;51(8):2505-13.PMID: 12145164 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Inhibitory effects of epicatechin on interleukin-1beta-induced inducible nitric oxide synthase expression in RINm5F cells and rat pancreatic islets by down-regulation of NF-kappaB activation.

    Kim MJ, Ryu GR, Kang JH, Sim SS, Min DS, Rhie DJ, Yoon SH, Hahn SJ, Jeong IK, Hong KJ, Kim MS, Jo YH.

    Biochem Pharmacol. 2004 Nov 1;68(9):1775-85.PMID: 15450943 [PubMed - indexed for MEDLINE]Related articles

    19.

    Relative importance of transport and alkylation for pancreatic beta-cell toxicity of streptozotocin.

    Elsner M, Guldbakke B, Tiedge M, Munday R, Lenzen S.

    Diabetologia. 2000 Dec;43(12):1528-33.PMID: 11151762 [PubMed - indexed for MEDLINE]Related articles

    20.

    Effects of cytotoxic agents on functional integrity and antioxidant enzymes in clonal beta-cells.

    Picton SF, McCluskey JT, Flatt PR, McClenaghan NH.

    Diabetes Metab. 2002 Dec;28(6 Pt 2):3S70-7; discussion 3S108-12.PMID: 12688636 [PubMed - indexed for MEDLINE]Related articles

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