PubMed

Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats.

Xu G, Stoffers DA, Habener JF, Bonner-Weir S.

Diabetes. 1999 Dec;48(12):2270-6.PMID: 10580413 [PubMed - indexed for MEDLINE]Related articlesFree article

Persistent improvement of type 2 diabetes in the Goto-Kakizaki rat model by expansion of the beta-cell mass during the prediabetic period with glucagon-like peptide-1 or exendin-4.

Tourrel C, Bailbe D, Lacorne M, Meile MJ, Kergoat M, Portha B.

Diabetes. 2002 May;51(5):1443-52.PMID: 11978641 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis.

Li Y, Hansotia T, Yusta B, Ris F, Halban PA, Drucker DJ.

J Biol Chem. 2003 Jan 3;278(1):471-8. Epub 2002 Oct 29.PMID: 12409292 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon-like peptide-1 and exendin-4 stimulate beta-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age.

Tourrel C, Bailbé D, Meile MJ, Kergoat M, Portha B.

Diabetes. 2001 Jul;50(7):1562-70.PMID: 11423477 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas.

Stoffers DA, Kieffer TJ, Hussain MA, Drucker DJ, Bonner-Weir S, Habener JF, Egan JM.

Diabetes. 2000 May;49(5):741-8.PMID: 10905482 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon-like peptide-1 treatment delays the onset of diabetes in 8 week-old db/db mice.

Wang Q, Brubaker PL.

Diabetologia. 2002 Sep;45(9):1263-73. Epub 2002 Apr 26.PMID: 12242459 [PubMed - indexed for MEDLINE]Related articles

Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats.

Perfetti R, Zhou J, Doyle ME, Egan JM.

Endocrinology. 2000 Dec;141(12):4600-5.PMID: 11108273 [PubMed - indexed for MEDLINE]Related articlesFree article

Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats.

Pospisilik JA, Martin J, Doty T, Ehses JA, Pamir N, Lynn FC, Piteau S, Demuth HU, McIntosh CH, Pederson RA.

Diabetes. 2003 Mar;52(3):741-50.PMID: 12606516 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of endogenous glucagon-like peptide-1 in islet regeneration after partial pancreatectomy.

De León DD, Deng S, Madani R, Ahima RS, Drucker DJ, Stoffers DA.

Diabetes. 2003 Feb;52(2):365-71.PMID: 12540609 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacology of exenatide (synthetic exendin-4): a potential therapeutic for improved glycemic control of type 2 diabetes.

Nielsen LL, Young AA, Parkes DG.

Regul Pept. 2004 Feb 15;117(2):77-88. Review.PMID: 14700743 [PubMed - indexed for MEDLINE]Related articles

Treatment of type 2 diabetes mellitus with agonists of the GLP-1 receptor or DPP-IV inhibitors.

Holst JJ.

Expert Opin Emerg Drugs. 2004 May;9(1):155-66. Review.PMID: 15155141 [PubMed - indexed for MEDLINE]Related articles

Exendin-4 and exercise promotes beta-cell function and mass through IRS2 induction in islets of diabetic rats.

Park S, Hong SM, Sung SR.

Life Sci. 2008 Feb 27;82(9-10):503-11. Epub 2007 Dec 31.PMID: 18237751 [PubMed - indexed for MEDLINE]Related articles

Once daily injection of exendin-4 to diabetic mice achieves long-term beneficial effects on blood glucose concentrations.

Greig NH, Holloway HW, De Ore KA, Jani D, Wang Y, Zhou J, Garant MJ, Egan JM.

Diabetologia. 1999 Jan;42(1):45-50.PMID: 10027577 [PubMed - indexed for MEDLINE]Related articles

Glucagon-like peptide-1.

Doyle ME, Egan JM.

Recent Prog Horm Res. 2001;56:377-99. Review.PMID: 11237222 [PubMed - indexed for MEDLINE]Related articlesFree article

Exendin 4 up-regulates expression of PDX 1 and hastens differentiation and maturation of human fetal pancreatic cells.

Movassat J, Beattie GM, Lopez AD, Hayek A.

J Clin Endocrinol Metab. 2002 Oct;87(10):4775-81.PMID: 12364473 [PubMed - indexed for MEDLINE]Related articlesFree article

Over-expression of the glucagon-like peptide-1 receptor on INS-1 cells confers autocrine stimulation of insulin gene promoter activity: a strategy for production of pancreatic beta-cell lines for use in transplantation.

Chepurny OG, Holz GG.

Cell Tissue Res. 2002 Feb;307(2):191-201. Epub 2002 Jan 8.PMID: 11845326 [PubMed - indexed for MEDLINE]Related articles

Glucagon-like peptide 1 agonists and the development and growth of pancreatic beta-cells.

List JF, Habener JF.

Am J Physiol Endocrinol Metab. 2004 Jun;286(6):E875-81. Review.PMID: 15140754 [PubMed - indexed for MEDLINE]Related articlesFree article

A pentadecapeptide fragment of islet neogenesis-associated protein increases beta-cell mass and reverses diabetes in C57BL/6J mice.

Rosenberg L, Lipsett M, Yoon JW, Prentki M, Wang R, Jun HS, Pittenger GL, Taylor-Fishwick D, Vinik AI.

Ann Surg. 2004 Nov;240(5):875-84.PMID: 15492571 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel peptides under development for the treatment of type 1 and type 2 diabetes mellitus.

Baron AD, Kim D, Weyer C.

Curr Drug Targets Immune Endocr Metabol Disord. 2002 Apr;2(1):63-82. Review.PMID: 12477297 [PubMed - indexed for MEDLINE]Related articles

The multifaceted potential of glucagon-like peptide-1 as a therapeutic agent.

Lam NT, Kieffer TJ.

Minerva Endocrinol. 2002 Jun;27(2):79-93. Review.PMID: 11961501 [PubMed - indexed for MEDLINE]Related articles