PubMed

A defect late in stimulus-secretion coupling impairs insulin secretion in Goto-Kakizaki diabetic rats.

Metz SA, Meredith M, Vadakekalam J, Rabaglia ME, Kowluru A.

Diabetes. 1999 Sep;48(9):1754-62.PMID: 10480605 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of mitochondrial FAD-linked glycerol-3-phosphate dehydrogenase does not correct glucose-stimulated insulin secretion from diabetic GK rat pancreatic islets.

Ueda K, Tanizawa Y, Ishihara H, Kizuki N, Ohta Y, Matsutani A, Oka Y.

Diabetologia. 1998 Jun;41(6):649-53.PMID: 9662045 [PubMed - indexed for MEDLINE]Related articles

Ca2+-secretion coupling is impaired in diabetic Goto Kakizaki rats.

Rose T, Efendic S, Rupnik M.

J Gen Physiol. 2007 Jun;129(6):493-508.PMID: 17535961 [PubMed - indexed for MEDLINE]Related articlesFree article

Electrophysiological and metabolic characterization of single beta-cells and islets from diabetic GK rats.

Hughes SJ, Faehling M, Thorneley CW, Proks P, Ashcroft FM, Smith PA.

Diabetes. 1998 Jan;47(1):73-81.PMID: 9421377 [PubMed - indexed for MEDLINE]Related articles

Insulin secretion from islets of GK rats is not impaired after energy generating steps.

Katayama N, Hughes SJ, Persaud SJ, Jones PM, Howell SL.

Mol Cell Endocrinol. 1995 Jun;111(2):125-8.PMID: 7556873 [PubMed - indexed for MEDLINE]Related articles

Decreased expression of t-SNARE, syntaxin 1, and SNAP-25 in pancreatic beta-cells is involved in impaired insulin secretion from diabetic GK rat islets: restoration of decreased t-SNARE proteins improves impaired insulin secretion.

Nagamatsu S, Nakamichi Y, Yamamura C, Matsushima S, Watanabe T, Ozawa S, Furukawa H, Ishida H.

Diabetes. 1999 Dec;48(12):2367-73.PMID: 10580425 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of protein-tyrosine phosphatases stimulates insulin secretion in pancreatic islets of diabetic Goto-Kakizaki rats.

Chen J, Ostenson CG.

Pancreas. 2005 May;30(4):314-7.PMID: 15841039 [PubMed - indexed for MEDLINE]Related articles

The possible mechanisms by which phanoside stimulates insulin secretion from rat islets.

Hoa NK, Norberg A, Sillard R, Van Phan D, Thuan ND, Dzung DT, Jörnvall H, Ostenson CG.

J Endocrinol. 2007 Feb;192(2):389-94.PMID: 17283239 [PubMed - indexed for MEDLINE]Related articlesFree article

Dysfunction of the islet lysosomal system conveys impairment of glucose-induced insulin release in the diabetic GK rat.

Salehi A, Henningsson R, Mosén H, Ostenson CG, Efendic S, Lundquist I.

Endocrinology. 1999 Jul;140(7):3045-53.PMID: 10385396 [PubMed - indexed for MEDLINE]Related articlesFree article

[Impaired insulin secretion in isolated islets of Goto-Kakizaki rats, an animal model of non obese type 2 diabetes, is a primary event]

Seiça RM, Suzuki KI, Santos RM, Do Rosário LM.

Acta Med Port. 2004 Jan-Feb;17(1):42-8. Epub 2004 Feb 27. Portuguese. PMID: 15636726 [PubMed - indexed for MEDLINE]Related articlesFree article

Src activation generates reactive oxygen species and impairs metabolism-secretion coupling in diabetic Goto-Kakizaki and ouabain-treated rat pancreatic islets.

Kominato R, Fujimoto S, Mukai E, Nakamura Y, Nabe K, Shimodahira M, Nishi Y, Funakoshi S, Seino Y, Inagaki N.

Diabetologia. 2008 Jul;51(7):1226-35. Epub 2008 May 1.PMID: 18449527 [PubMed - indexed for MEDLINE]Related articles

Hyperresponse in calcium-induced insulin release from electrically permeabilized pancreatic islets of diabetics GK rats and its defective augmentation by glucose.

Okamoto Y, Ishida H, Tsuura Y, Yasuda K, Kato S, Matsubara H, Nishimura M, Mizuno N, Ikeda H, Seino Y.

Diabetologia. 1995 Jul;38(7):772-8.PMID: 7556977 [PubMed - indexed for MEDLINE]Related articles

Functional and metabolic perturbations in isolated pancreatic islets from the GK rat, a genetic model of noninsulin-dependent diabetes.

Giroix MH, Vesco L, Portha B.

Endocrinology. 1993 Feb;132(2):815-22.PMID: 8425496 [PubMed - indexed for MEDLINE]Related articles

An early insulin intervention accelerates pancreatic beta-cell dysfunction in young Goto-Kakizaki rats, a model of naturally occurring noninsulin-dependent diabetes.

Suzuki N, Aizawa T, Asanuma N, Sato Y, Komatsu M, Hidaka H, Itoh N, Yamauchi K, Hashizume K.

Endocrinology. 1997 Mar;138(3):1106-10.PMID: 9048616 [PubMed - indexed for MEDLINE]Related articlesFree article

Abnormal insulin secretion and glucose metabolism in pancreatic islets from the spontaneously diabetic GK rat.

Ostenson CG, Khan A, Abdel-Halim SM, Guenifi A, Suzuki K, Goto Y, Efendic S.

Diabetologia. 1993 Jan;36(1):3-8.PMID: 8436249 [PubMed - indexed for MEDLINE]Related articles

Effects of palmitate on insulin secretion and exocytotic proteins in islets of diabetic Goto-Kakizaki rats.

Ostenson CG, Chen J, Sheu L, Gaisano HY.

Pancreas. 2007 Apr;34(3):359-63.PMID: 17414060 [PubMed - indexed for MEDLINE]Related articles

Insulin secretion is stimulated by ethanol extract of Anemarrhena asphodeloides in isolated islet of healthy Wistar and diabetic Goto-Kakizaki Rats.

Hoa NK, Phan DV, Thuan ND, Ostenson CG.

Exp Clin Endocrinol Diabetes. 2004 Oct;112(9):520-5.PMID: 15505760 [PubMed - indexed for MEDLINE]Related articles

Decreased pancreatic islet response to L-leucine in the spontaneously diabetic GK rat: enzymatic, metabolic and secretory data.

Giroix MH, Saulnier C, Portha B.

Diabetologia. 1999 Aug;42(8):965-77.PMID: 10491757 [PubMed - indexed for MEDLINE]Related articles

Preserved initiatory and potentiatory effect of alpha-ketoisocaproate on insulin release in islets of glucose intolerant rats.

Guenifi A, Abdel-Halim SM, Efendic S, Ostenson CG.

Diabetologia. 1998 Nov;41(11):1368-73.PMID: 9833946 [PubMed - indexed for MEDLINE]Related articles

Pancreatic islet response to dicarboxylic acid esters in rats with type 2 diabetes: enzymatic, metabolic and secretory aspects.

Rasschaert J, Giroix MH, Conget I, Mercan D, Leclercq-Meyer V, Sener A, Portha B, Malaisse WJ.

J Mol Endocrinol. 1994 Oct;13(2):209-17.PMID: 7848532 [PubMed - indexed for MEDLINE]Related articles