PubMed

New concept for long-acting insulin: spontaneous conversion of an inactive modified insulin to the active hormone in circulation: 9-fluorenylmethoxycarbonyl derivative of insulin.

Gershonov E, Shechter Y, Fridkin M.

Diabetes. 1999 Jul;48(7):1437-42.PMID: 10389850 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel approach for a water-soluble long-acting insulin prodrug: design, preparation, and analysis of [(2-sulfo)-9-fluorenylmethoxycarbonyl](3)-insulin.

Gershonov E, Goldwaser I, Fridkin M, Shechter Y.

J Med Chem. 2000 Jun 29;43(13):2530-7.PMID: 10891112 [PubMed - indexed for MEDLINE]Related articles

Reversible pegylation of insulin facilitates its prolonged action in vivo.

Shechter Y, Mironchik M, Rubinraut S, Tsubery H, Sasson K, Marcus Y, Fridkin M.

Eur J Pharm Biopharm. 2008 Sep;70(1):19-28. Epub 2008 Apr 7.PMID: 18495444 [PubMed - indexed for MEDLINE]Related articles

Albumin-insulin conjugate releasing insulin slowly under physiological conditions: a new concept for long-acting insulin.

Shechter Y, Mironchik M, Rubinraut S, Saul A, Tsubery H, Fridkin M.

Bioconjug Chem. 2005 Jul-Aug;16(4):913-20.PMID: 16029032 [PubMed - indexed for MEDLINE]Related articles

Enhanced cAMP generation and insulin-releasing potency of two novel Tyr1-modified enzyme-resistant forms of glucose-dependent insulinotropic polypeptide is associated with significant antihyperglycaemic activity in spontaneous obesity-diabetes.

Gault VA, Flatt PR, Bailey CJ, Harriott P, Greer B, Mooney MH, O'harte FP.

Biochem J. 2002 Nov 1;367(Pt 3):913-20.PMID: 12150711 [PubMed - indexed for MEDLINE]Related articlesFree article

Suspensions of pro-drug insulin greatly prolong normoglycemic patterns in diabetic rats.

Shechter Y, Tsubery H, Fridkin M.

Biochem Biophys Res Commun. 2003 Jul 25;307(2):315-21.PMID: 12859957 [PubMed - indexed for MEDLINE]Related articles

Prolonging the half-life of human interferon-alpha 2 in circulation: Design, preparation, and analysis of (2-sulfo-9-fluorenylmethoxycarbonyl)7- interferon-alpha 2.

Shechter Y, Preciado-Patt L, Schreiber G, Fridkin M.

Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1212-7.PMID: 11158619 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased responses of glucagon and glucose production to hypoglycemia with intraperitoneal versus subcutaneous insulin treatment.

Wan CK, Giacca A, Matsuhisa M, El-Bahrani B, Lam L, Rodgers C, Shi ZQ.

Metabolism. 2000 Aug;49(8):984-9.PMID: 10954014 [PubMed - indexed for MEDLINE]Related articles

Reversible pegylation prolongs the hypotensive effect of atrial natriuretic peptide.

Nesher M, Vachutinsky Y, Fridkin G, Schwarz Y, Sasson K, Fridkin M, Shechter Y, Lichtstein D.

Bioconjug Chem. 2008 Jan;19(1):342-8. Epub 2007 Dec 11.PMID: 18069777 [PubMed - indexed for MEDLINE]Related articles

Blood glucose profiles in diabetic rodents using different insulin preparations.

Schneider S, Weber R, Luippold G.

Arzneimittelforschung. 2004;54(12):842-6.PMID: 15646368 [PubMed - indexed for MEDLINE]Related articles

[2-Sulfo-9-fluorenylmethoxycarbonyl]3-exendin-4-a long-acting glucose-lowering prodrug.

Shechter Y, Tsubery H, Fridkin M.

Biochem Biophys Res Commun. 2003 May 30;305(2):386-91.PMID: 12745087 [PubMed - indexed for MEDLINE]Related articles

Hypoglycemic effect of Hypoxis hemerocallidea corm (African potato) aqueous extract in rats.

Mahomed IM, Ojewole JA.

Methods Find Exp Clin Pharmacol. 2003 Oct;25(8):617-23.PMID: 14671679 [PubMed - indexed for MEDLINE]Related articles

Hypoglycemic effect of insulin-transferrin conjugate in streptozotocin-induced diabetic rats.

Xia CQ, Wang J, Shen WC.

J Pharmacol Exp Ther. 2000 Nov;295(2):594-600.PMID: 11046093 [PubMed - indexed for MEDLINE]Related articlesFree article

Controlled release of insulin from pH/temperature-sensitive injectable pentablock copolymer hydrogel.

Huynh DP, Im GJ, Chae SY, Lee KC, Lee DS.

J Control Release. 2009 Jul 1;137(1):20-4. Epub 2009 Mar 12.PMID: 19285530 [PubMed - indexed for MEDLINE]Related articles

N-[(2-Sulfo)-9-fluorenylmethoxycarbonyl](3)-gentamicin C(1) is a long-acting prodrug derivative.

Shechter Y, Tsubery H, Fridkin M.

J Med Chem. 2002 Sep 12;45(19):4264-70.PMID: 12213067 [PubMed - indexed for MEDLINE]Related articles

[A 50-year history of new drugs in Japan-the development and progress of anti-diabetic drugs and the epidemiological aspects of diabetes mellitus]

Ozawa H, Murai Y, Ozawa T.

Yakushigaku Zasshi. 2003;38(1):11-27. Japanese. PMID: 14570054 [PubMed - indexed for MEDLINE]Related articles

Tricalcium phosphate delayed release formulation for oral delivery of insulin: a proof-of-concept study.

Paul W, Sharma CP.

J Pharm Sci. 2008 Feb;97(2):875-82.PMID: 17497735 [PubMed - indexed for MEDLINE]Related articles

A lecithin-based microemulsion of rh-insulin with aprotinin for oral administration: Investigation of hypoglycemic effects in non-diabetic and STZ-induced diabetic rats.

Cilek A, Celebi N, Tirnaksiz F, Tay A.

Int J Pharm. 2005 Jul 14;298(1):176-85.PMID: 15950411 [PubMed - indexed for MEDLINE]Related articles

Effects of QD insulin detemir or neutral protamine Hagedorn on blood glucose control in patients with type I diabetes mellitus using a basal-bolus regimen.

Russell-Jones D, Simpson R, Hylleberg B, Draeger E, Bolinder J.

Clin Ther. 2004 May;26(5):724-36.PMID: 15220016 [PubMed - indexed for MEDLINE]Related articles

Biological activity of AC3174, a peptide analog of exendin-4.

Hargrove DM, Kendall ES, Reynolds JM, Lwin AN, Herich JP, Smith PA, Gedulin BR, Flanagan SD, Jodka CM, Hoyt JA, McCowen KM, Parkes DG, Anderson CM.

Regul Pept. 2007 Jun 7;141(1-3):113-9. Epub 2007 Jan 11.PMID: 17292977 [PubMed - indexed for MEDLINE]Related articles