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    Genomics. 1998 Nov 15;54(1):173-5.

    Genomic organization and expression of the human beta-synuclein gene (SNCB).

    Lavedan C, Leroy E, Torres R, Dehejia A, Dutra A, Buchholtz S, Nussbaum RL, Polymeropoulos MH.

    National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA.

    The beta-synuclein protein is highly homologous to the alpha-synuclein protein for which two mutations were reported in some familial cases of Parkinson disease. It has been shown that both alpha- and beta-synucleins may be able to inhibit phospholipase D2 selectively. We have observed that the beta-synuclein gene (HGMW-approved symbol, SNCB) is highly expressed in brain including the substantia nigra, the main region of neuronal degeneration in patients with Parkinson disease. We have determined the intron-exon structure of the beta-synuclein gene and established sequencing assays that will facilitate the search for mutations in the beta-synuclein gene in patients with Parkinson disease or other neurodegenerative disorders. Copyright 1998 Academic Press.

    PMID: 9806846 [PubMed - indexed for MEDLINE]

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