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    J Mol Biol. 1998 Oct 23;283(2):435-49.

    X-ray structures and analysis of 11 cyclosporin derivatives complexed with cyclophilin A.

    Kallen J, Mikol V, Taylor P, Walkinshaw MD.

    The University of Edinburgh, Michael Swann Building, Edinburgh, EH9 3JR, UK.

    Eight new X-ray structures of different cyclophilin A/cyclosporin-derivative complexes are presented. These structures, combined with the existing three published cyclosporin complexes, provide a useful structural database for the analysis of protein-ligand interactions. The effect of small chemical differences on protein-ligand hydrogen-bonding, van der Waals interactions and water structure is presented. Copyright 1998 Academic Press.

    PMID: 9769216 [PubMed - indexed for MEDLINE]

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