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    Gene. 1998 Oct 5;220(1-2):99-108.

    Characterization of the gene for human EMMPRIN, a tumor cell surface inducer of matrix metalloproteinases.

    Guo H, Majmudar G, Jensen TC, Biswas C, Toole BP, Gordon MK.

    Department of Anatomy and Cellular Biology, Tufts Medical School, Boston, Massachusetts, USA.

    EMMPRIN (extracellular matrix metalloproteinase inducer) also known as CD147 and basigin, is a member of the immunoglobulin family that is present on the surface of tumor cells and stimulates nearby fibroblasts to synthesize matrix metalloproteinases. Using our EMMPRIN cDNA, we have isolated a cosmid clone that contains the human EMMPRIN gene. S1 analysis with a fragment of the gene clone and primer extension of the mRNA was performed to determine the transcription start site. PCR and sequence analysis have defined the exon/intron organization of the gene and show that it is highly conserved with the mouse EMMPRIN/basigin gene. About 950 bases of the 5'-flanking region were examined for transcription factor consensus binding sites, locating three SP1 sites and two AP2 sites. The transcription start site was found to be located in a CpG island. Elements in the proximal promoter region were conserved in the human and mouse genes.

    PMID: 9767135 [PubMed - indexed for MEDLINE]

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