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    Gene. 1998 Sep 28;219(1-2):125-30.

    The genomic organization of the human corticotropin-releasing factor type-1 receptor.

    Sakai K, Yamada M, Horiba N, Wakui M, Demura H, Suda T.

    Third Division, Department of Medicine, Hirosaki University School of Medicine, Hirosaki 036, Japan. yokos@cc.hirosaki-u.ac.jp

    We determined the genomic organization of human CRF type-1 receptor (hCRF-R1). The gene coding for hCRF-R1 consists of at least 14 exons and spans over 20 kilobases. hCRF-R1's three reported isoforms originate from the same gene by alternative splicing. The first hCRF-R1, which binds to CRF with the highest affinity and transduces the most sensitive cAMP accumulation in response to CRF, is encoded in a total of 13 exons, the only one excluded being exon 6. The second isoform contains an additional 29-amino acid sequence which corresponds to exon 6. Unlike the first isoform, the third lacks a 40-amino acid sequence, corresponding to exon 3. Exon-intron boundaries are the same as that of the consensus sequence. Locations of introns in the coding sequence are similar to human CRF-R1, rat CRF-R1, human CRF-R2alpha and others belonging to the human glucagon receptor family.

    PMID: 9757017 [PubMed - indexed for MEDLINE]

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    Patient drug information

    • Glucagon (GlucaGen Diagnostic Kit®)

      Glucagon is a hormone produced in the pancreas. Glucagon is used to raise very low blood sugar. Glucagon is also used in diagnostic testing of the stomach and other digestive organs.

    • Source: AHFS Consumer Medication Information

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