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    Science. 1998 Sep 18;281(5384):1860-3.

    Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx.

    Chang HY, Nishitoh H, Yang X, Ichijo H, Baltimore D.

    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02138, USA.

    The Fas death receptor can activate the Jun NH2-terminal kinase (JNK) pathway through the receptor-associated protein Daxx. Daxx was found to activate the JNK kinase kinase ASK1, and overexpression of a kinase-deficient ASK1 mutant inhibited Fas- and Daxx-induced apoptosis and JNK activation. Fas activation induced Daxx to interact with ASK1, which consequently relieved an inhibitory intramolecular interaction between the amino- and carboxyl-termini of ASK1, activating its kinase activity. The Daxx-ASK1 connection completes a signaling pathway from a cell surface death receptor to kinase cascades that modulate nuclear transcription factors.

    PMID: 9743501 [PubMed - indexed for MEDLINE]

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