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    FEBS Lett. 1998 May 22;428(1-2):80-4.

    N-copine: a novel two C2-domain-containing protein with neuronal activity-regulated expression.

    Nakayama T, Yaoi T, Yasui M, Kuwajima G.

    CNS Research Laboratories, Shionogi and Co., Ltd., Osaka, Japan.

    Neuronal activity is often associated with changes in gene expression. By a two-dimensional cDNA-display system, restriction landmark cDNA scanning, we identified a novel gene whose expression in the hippocampus was up-regulated by kainate stimulation. The mRNA expression was detected only in brain and up-regulated by the stimulation evoking CA3-CA1 long-term potentiation. The encoded protein contains two copies of C2-domain, known as the Ca2+-binding domain of PKC-gamma, and shows 49% identity with human copine I. We designated this protein N-copine (neuronal-copine). N-copine may have a role in synaptic plasticity.

    PMID: 9645480 [PubMed - indexed for MEDLINE]

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