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    Gene. 1997 Dec 5;203(1):27-31.

    Cloning and structural analysis of the murine GCN5L1 gene.

    Driessen CA, Winkens HJ, Kuhlmann LD, Janssen BP, van Vugt AH, Deutman AF, Janssen JJ.

    University of Nijmegen, Department of Ophthalmology, The Netherlands. c.driessen@ohk.azn.nl

    We recently cloned the murine 11-cis retinol dehydrogenase gene. A second gene, the murine GCN5L1 gene, was found to be situated upstream of the murine 11-cis retinol dehydrogenase gene. We have isolated and sequenced the complete coding sequence of the murine GCN5L1 gene. The distance between the 3'-end of the murine GCN5L1 gene and the 5'-end of the 11-cis retinol dehydrogenase gene is only 776 nt. The murine GCNSL1 gene consists of four exons encompassing approximately 3.5 kb of genomic DNA. Intron/exon splice sites conform to the GT/AG rule. The open reading frame consists of 375 nucleotides encoding a 14 kDa protein. The murine GCN5L1, like the human GCN5L1 protein, displays weak homology (27%) to yeast GCN5. The distance between the murine, human and bovine GCN5L1 and 11-cis retinol dehydrogenase genes appeared to be conserved.

    PMID: 9426003 [PubMed - indexed for MEDLINE]

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