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    Nature. 1997 Nov 6;390(6655):45-51.

    Mutation of the mouse klotho gene leads to a syndrome resembling ageing.

    Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, Ohyama Y, Kurabayashi M, Kaname T, Kume E, Iwasaki H, Iida A, Shiraki-Iida T, Nishikawa S, Nagai R, Nabeshima YI.

    Division of Molecular Genetics, National Institute of Neuroscience, Kodaira, Tokyo, Japan. kuroo@ncnaxp.ncnp.go.jp

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    A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema. The gene encodes a membrane protein that shares sequence similarity with the beta-glucosidase enzymes. The klotho gene product may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases.

    PMID: 9363890 [PubMed - indexed for MEDLINE]

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